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Pharmaceutical raw materials Pralidoxime Chloride powder
Product Overview:
PralidoximeChloride, alias Pham chloride, Pralidoximechloride, etc., is an organophosphate antidote and other rescue drugs, as well as a cholinesterase reactivator. It is an injectable drug, mainly used for the rescue of moderate and severe organophosphorus poisoning, and has good curative effect on parathion, internal absorption phosphorus, methamidophos, and Terp. Its nucleophilic groups can be directly combined with the phosphorylated groups of cholinesterase and then jointly separated from cholinesterase, so that cholinesterase can return to its original state and show vitality again, so as to relieve the symptoms of poisoning. For mild organophosphorus poisoning, it can be used alone to control symptoms; Atropine must be used in combination with moderate and severe poisoning. After intravenous administration, the effective concentration in the blood is quickly reached, and the large dose can also enter the brain tissue through the blood-brain barrier, and is quickly discharged by the kidney, without accumulation of poisoning phenomenon, which has been widely used and generated by a number of drug companies in China.
Pharmaceutical raw materials Pralidoxime Chloride powder Attributes
CAS:51-15-0
MF:C7H9ClN2O
MW:172.61
EINECS:200-080-9
Specification: 99% min Pralidoxime Chloride
Sample:Pralidoxime Chloride
Packaging:1kg/bag, 25kg/drum
Brand: Henrikang
Appearance:white
Storage: Cool Dry Place
Shelf Life: 2 Years
Test Method: HPLC
Pharmaceutical raw materials Pralidoxime Chloride powder Details
Pralidoxime Chloride Usage and Synthesis.
The quaternary ammonium group can tend to the cationic site of phosphoacylated cholinesterase which has been deactivated by binding with organophosphorus insecticides. Its nucleophilic group can directly bind with the phosphorylated group of cholinesterase and then jointly dissociate cholinesterase, so that cholinesterase can return to its original state and become active again. The "aged" cholinesterase inhibited by organophosphorus insecticides for more than 36h had poor reactivation effect. The e effect on nicotinoid symptoms caused by organophosphus insecticides is obvious, while the E effect on central nervous system symptoms is weak.
Uses of Pralidoxime Chloride.
It can replace pralidoxime iodide and revive cholinesterase activity inhibited by acute organophosphorus insecticides to varying degrees, and save the poisoning of many organophosphate insecticides, but it has no revival effect on cholinesterase inhibited by carbamate insecticides, and has poor rescue effect on malathion, trichlorfon, dichlorvos, Dimethoate, mefluron, propylamphos and octamethion poisoning.
Pharmacological action of Pralidoxime Chloride.
Product Method of Bulk Pralidoxime Chloride.
2-methylpyridine reacted with chloromethane to obtain 2-methylpyridine chloromethane salt, and then nitrified the group with ethyl nitrite to obtain sodium phosphodoxide chloride salt, and then neutralized in ethanol solution with concentrated hydrochloric acid to pH=3-4, filtered sodium chloride, and concentrated ethanol under reduced pressure to obtain crude phosphodoxide chloride, dissolved by distilled water, decolorized by activated carbon, and recrystallized to obtain finished product.
