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Supply Ropivacaine Hydrochloride Raw Materials powder
Product Overview:
Ropicaramide hydrochloride long-acting local anesthetics. Its fat solubility is greater than lidocaine, less than bupivacaine, and its anesthetic strength is 8 times that of procaine. Because the products of its metabolism in the liver also have local anesthetic effect, so the effect is more lasting. It is mainly used for regional block anesthesia and epidural anesthesia for postoperative and labor analgesia.
Supply Ropivacaine Hydrochloride Raw Materials powder Attributes
CAS:98717-15-8
MF:C17H27ClN2O
MW:310.86
EINECS:1312995-182-4
Specification: 99% min Ropivacaine Hydrochloride
Sample:Ropivacaine Hydrochloride powder
Packaging:1kg/bag, 25kg/drum
Brand: Henrikang
Appearance:white
Storage: Cool Dry Place
Shelf Life: 2 Years
Test Method: HPLC
Supply Ropivacaine Hydrochloride Raw Materials powder Details
Ropivacaine Hydrochloride of Usage and Synthesis.
Ropivacainehydrochloride is an effective sodiumchannel blocker. Ropivacaine induces nerve fiber pulse block by reversibly inhibiting sodium influx. Ropivacaine is also an inhibitor of K2P(two-pore potassium channel)TREK-1 with an IC50 value of 402.7μM on COS-7 cell membranes. Ropivacaine is used in animal models for local anesthesia and relief of neuropathic pain.
Uses of Ropivacaine Hydrochloride.
Ropivacaine is a new type of long-acting amide local anesthetic, which has a long duration of action and has anesthetic and analgesic effects.
Pharmacological action of Ropivacaine Hydrochloride.
Ropivacaine, the first pure levo-body long-acting amide local anesthetic, has both anesthetic and analgesic effects, with large doses producing surgical anesthesia and small doses producing sensory block (analgesia) accompanied only by limited non-progressive motor nerve block. Addition of epinephrine did not change the blocking intensity and duration of ropivacaine. Ropivacaine reversibly blocks impulse conduction along nerve fibers by blocking the flow of sodium ions into the membrane of nerve fibers. Local anesthetics may also have a similar effect on excitable cell membranes such as brain cells and cardiomyocytes, and if excess drugs enter the systemic circulation quickly, the central nervous system and cardiovascular system will show signs and symptoms of intoxication. Pregnant ewes did not show a greater sensitivity to ropivacaine than non-pregnant ewes. Intravenous administration of ropivacaine was well tolerated in healthy volunteers, and clinical experience with this drug suggests a good safety range. Indirect cardiovascular effects (hypotension, bradycardia) may occur with epidural use, depending on the degree of parasympathetic block.
Product method of Bulk Ropivacaine Hydrochloride Powder.
