Supply Ropivacaine Hydrochloride Raw Materials powder

CAS:98717-15-8

MF:C17H27ClN2O

MW:310.86

EINECS:1312995-182-4

Specification: 99% min Ropivacaine Hydrochloride

Sample:Ropivacaine Hydrochloride powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance:white

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Ropivacaine Hydrochloride of Usage and Synthesis.

Ropivacainehydrochloride is an effective sodiumchannel blocker. Ropivacaine induces nerve fiber pulse block by reversibly inhibiting sodium influx. Ropivacaine is also an inhibitor of K2P(two-pore potassium channel)TREK-1 with an IC50 value of 402.7μM on COS-7 cell membranes. Ropivacaine is used in animal models for local anesthesia and relief of neuropathic pain.

Uses of Ropivacaine Hydrochloride.

Ropivacaine is a new type of long-acting amide local anesthetic, which has a long duration of action and has anesthetic and analgesic effects.

Pharmacological action of Ropivacaine Hydrochloride.

Ropivacaine, the first pure levo-body long-acting amide local anesthetic, has both anesthetic and analgesic effects, with large doses producing surgical anesthesia and small doses producing sensory block (analgesia) accompanied only by limited non-progressive motor nerve block. Addition of epinephrine did not change the blocking intensity and duration of ropivacaine. Ropivacaine reversibly blocks impulse conduction along nerve fibers by blocking the flow of sodium ions into the membrane of nerve fibers. Local anesthetics may also have a similar effect on excitable cell membranes such as brain cells and cardiomyocytes, and if excess drugs enter the systemic circulation quickly, the central nervous system and cardiovascular system will show signs and symptoms of intoxication. Pregnant ewes did not show a greater sensitivity to ropivacaine than non-pregnant ewes. Intravenous administration of ropivacaine was well tolerated in healthy volunteers, and clinical experience with this drug suggests a good safety range. Indirect cardiovascular effects (hypotension, bradycardia) may occur with epidural use, depending on the degree of parasympathetic block.

Product method of Bulk Ropivacaine Hydrochloride Powder.