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HRK Supply Glycyrrhetic Acid raw Materials powder
Product Overview:
Licorice (Glycyrrhize glabra L.) is a common medicinal and edible food. Licorice extract is widely used as a natural sweetener in sweets and canned foods. The sweet taste of licorice comes from Glycyrrhizic acid and Glycyrrhetinic acid. The former is a class of triterpenoid saponins, accounting for about 4% to 5% of the dry weight of licorice root, and the sweetness is 50 times that of sucrose. Glycyrrhetinic acid is formed by glycyrrhizic acid water to remove the sugar acid chain, and the sweetness is 250 times that of sucrose. Glycyrrhetinic acid is cytotoxic, and long-term consumption of glycyrrhiza (100g/d) can lead to severe hypertension and cardiac hypertrophy, clinical symptoms are sodium ion retention and potassium ion expulsion, and severe cases can lead to extreme weakness and ventricular fibrillation.
HRK Supply Glycyrrhetic Acid raw Materials powder Attributes
CAS:471-53-4
MF:C30H46O4
MW:470.69
EINECS:207-444-6
Specification: 99% min Glycyrrhetic Acid Powder
Sample:Glycyrrhetic Acid Powder
Packaging:1kg/bag, 25kg/drum
Brand: Henrikang
Appearance:white
Storage: Cool Dry Place
Shelf Life: 2 Years
Test Method: HPLC
HRK Supply Glycyrrhetic Acid raw Materials powder Details
Glycyrrhetic Acid Powder Usage and Synthesis.
Glycyrrhizic acid and glycyrrhetinic acid have certain anti-cancer and anti-cancer effects. Glycyrrhetinic acid can inhibit information transmission and gene expression of proto-cancer cells. Glycyrrhizic acid can inhibit malignant tumors induced by various carcinogens in experimental animals. Glycyrrhetinic acid also has an anti-viral effect, and inhibits the infection of carcinogenic viruses such as hepatitis virus, Epstein-Barr virus and HIV.
Uses of Glycyrrhetic Acid.
Sweetener; Sweet improvers; Flavoring agent (combined with salt, the effect is particularly large); Flavor enhancer (dairy products, cocoa products, egg products, mutton, etc., to remove the smell of mutton). Our folk used for sauce and sauce products, pickled products and so on. It is an important pharmaceutical and high-grade cosmetic raw material, with anti-inflammatory, anti-allergic, inhibit bacterial reproduction and other effects. This product is an anti-inflammatory drug. It is used to treat adrenocortical hypofunction, gastric and duodenal ulcer and other diseases. Antibiotics used to treat staphylococcus, streptococcus, Escherichia coli, Helicobacter, and other infections.
Pharmacological action of Glycyrrhetic Acid.
Effect on the digestive system
Glycyrrhetinic acid can reduce blood bilirubin and increase urine bilirubin excretion in rabbits and rats with total bile duct ligation, and this effect is stronger than that of glucuronolactone or methionine. It has good anti-ulcer effect on pyloric ligation rats. Its therapeutic index is higher.
Antitussive and expectorant effect
Choline salt of glycyrrhetinic acid has obvious antitussive effect on cough caused by chemical stimulation (inhalation of ammonia) and electrical stimulation of upper laryngeal nerve in cats. Therefore, it is believed that its antitussive effect is related to the center.
Antitumor effect
It can inhibit the growth of transplanted Oberling-gnerin myeloma in rats, and can slightly inhibit the growth of FAC and sarcoma-45 cells in mice at the maximum tolerated dose of sodium salt.
Antidiuretic effect
Glycyrrhetinic acid and its salts have obvious antidiuretic effect. It can enhance the reabsorption of sodium chloride by renal tubules and show antidiuretic effect. Its mode of action is different from desoxycorticosterone, which may be due to its direct effect on the renal tubules.
Product method of Bulk Glycyrrhetic Acid Powder.
The extract of licorice (see "02317 Licorice") is concentrated and dried, coarse crystals are prepared, and then recrystallized in dilute alcohol. The yield of 6%-14% can also be directly extracted with ammonia water, after concentration, precipitated with sulfuric acid, and then recrystallized with 95% ethanol.
