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raw Materials powder Iodixanol
Product Overview:
Iodoxanol belongs to the United States General Pharmaceutical Company (GE) products, and the iodoxanol put into the market in China is produced by Sweden and is a class B medical insurance drug. Ioxanol is an isoosmotic contrast agent with low concentration. The concentrations of 270mgI/ml and 320mgI/ml are both lower than those of other contrast agents currently in use and consistent with human plasma osmotic pressure. Therefore, under the condition that the imaging images are consistent, patients can obviously get more comfort, safety and low risk when using contrast agents. The dose of patients receiving angiography is reduced, the risk of kidney damage is reduced, and the need for patient care is met. Therefore, more and more hospitals began to use ioxanol and widely used in various types of interventional imaging and children, the elderly and renal insufficiency, cardiac insufficiency and diabetes patients.
raw Materials powder Iodixanol Attributes
CAS:92339-11-2
MF:C35H44I6N6O15
MW:1550.18
EINECS:618-837-0
Specification: 99% min Iodixanol powder
Sample:Iodixanol powder
Packaging:1kg/bag, 25kg/drum
Brand:Henrikang
Appearance:white
Storage: Cool Dry Place
Shelf Life: 2 Years
Test Method: HPLC
raw Materials powder Iodixanol Details
Iodixanol powder Usage and Synthesis.
Iodixanol, chemical name 5,5'‑((2‑ hydroxyl ‑1,3‑ propane) bis (acetylimide) bis (N,N ‑2, 3‑ hydroxy propyl) bis (N,N ‑2, 3‑ hydroxy propyl)‑2,4,6‑ triiodol ‑1,3‑ phenylphthalamide, developed by Nycomed, Norway, It is a new type of non-ionic X-ray contrast agent (290mosmol/kg osmotic pressure) and is the only contrast agent that is isotonic with plasma when applied intravascular.
Uses of Iodixanol.
X-ray contrast medium. Angiocardiography, cerebrovascular angiography (routine with i.a. DSA), peripheral arteriography (routine with i.a. DSA), abdominal angiography (i.a. DSA), urography, venography, and CT-enhanced examination are performed in adults.
Preparation of Iodixanol.
Combine potassium hydroxide (112.7g,2mol), the intermediate "ioxanol?" 2 "(1kg,1.33mol) dissolved in water (1.25L). Potassium dihydrogen phosphate (45.5g) and dipotassium hydrogen phosphate (106.9g) were added and stirred for a while, and epichlorohydrin (68.1g,0.8mol) was added. After stirring for 48h, the HPLC yield of ioxanol was 92%. Concentrated hydrochloric acid was added to the reaction system to adjust the PH value of the solution to 7, 3Kg strong acidic ion exchange resin was added and stirred for 1 hour, then filtered and washed, 3kg strong basic ions were added to the mother liquor, and the resin was changed and stirred for 1 hour, then filtered and washed, and the mother liquor was reduced pressure and concentrated to obtain white solid ioxanol crude. The crude product was recrystallized with a mixture of methanol and water to obtain a white solid quality of 782 g iodoxanol (liquid purity of 99.6%).
Product Methods of Iodixanol.
