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  • Pharmaceutical Felodipine Raw Materials Powder

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    Product Overview:

    Felodipine is used to treat high blood pressure. It is a selective calcium ion antagonist, which mainly inhibits the intracellular calcium flow of arteriole smooth muscle, selectively dilates arteriole, has no effect on veins, and does not cause postural hypotension; There was no obvious inhibitory effect on myocardium. While reducing the renal vascular resistance, this product does not affect the glomerular filtration rate and creatinine clearance rate, the renal blood flow does not change or even slightly increase, and has the effect of promoting sodium excretion and diuresis. This product can increase output and cardiac index, significantly reduce afterload, but has no significant effect on cardiac systolic function, preload and heart rate.

    Pharmaceutical Felodipine Raw Materials Powder Attributes

    Felodipine Raw Materials Powder

    CAS:72509-76-3

    MF:C18H19Cl2NO4

    Felodipine

    MW:384.25

    EINECS:620-472-7

    Specification: 99% min Felodipine Powder

    Sample:Felodipine

    Packaging:1kg/bag, 25kg/drum

    Brand: Henrikang

    Appearance:light yellow

    Storage: Cool Dry Place

    Shelf Life: 2 Years

    Test Method: HPLC

    Pharmaceutical Felodipine Raw Materials Powder Details

    Felodipine Powder Usage and Synthesis.

    Used to treat high blood pressure. It is a selective calcium ion antagonist, which mainly inhibits the intracellular calcium flow of arteriole smooth muscle, selectively dilates arteriole, has no effect on veins, and does not cause postural hypotension; There was no obvious inhibitory effect on myocardium. While reducing the renal vascular resistance, this product does not affect the glomerular filtration rate and creatinine clearance rate, the renal blood flow does not change or even slightly increase, and has the effect of promoting sodium excretion and diuresis. This product can increase output and cardiac index, significantly reduce afterload, but has no significant effect on cardiac systolic function, preload and heart rate.

    Felodipine powder

    Pharmacological action of Felodipine.

    The mechanism of the action of felodipine is mainly two aspects: (1) it can reduce the systemic blood pressure; ② It can make the glomerular entry arteriole get sustained expansion. Therefore, felodipine can increase renal blood flow and glomerular filtration rate, improve the condition of renal ischemia, and prevent the disorder of renal vessel and glomerular structure and function. In addition, by regulating the passage of macromolecular substances through the glomerular basement membrane, the metabolic activity of residual kidney tissue can be reduced to a certain extent, and the formation of free radicals can be reduced to protect the kidneys. However, the disadvantage of felodipine is that kidney disease is significantly delayed in patients with kidney disease and a large amount of proteinuria. The main effect of felodipine is to reduce the systolic blood pressure and pulse pressure, and improve the endothelial function of blood vessels. To the point of anti-atherosclerosis.

    Felodipine

    Uses of Felodipine.

    Used to treat high blood pressure. It is a selective calcium ion antagonist, which mainly inhibits the intracellular calcium flow of arteriole smooth muscle, selectively dilates arteriole, has no effect on veins, and does not cause postural hypotension; There was no obvious inhibitory effect on myocardium. While reducing the renal vascular resistance, this product does not affect the glomerular filtration rate and creatinine clearance rate, the renal blood flow does not change or even slightly increase, and has the effect of promoting sodium excretion and diuresis. This product can increase output and cardiac index, significantly reduce afterload, but has no significant effect on cardiac systolic function, preload and heart rate. Calcium antagonist. For mild, moderate or severe hypertension, heart failure and ischemic heart disease.

    Felodipine raw

    Product method of Bulk Felodipine Powder.

    2, 3-dichlorobenzaldehyde, 3-aminobutyrate methyl ester and ethyl acetoacetate were reflow in isopropyl alcohol to obtain filodipine. Or 2, 3-dichlorobenzaldehyde condensates with methyl acetoacetate and ethyl 3-aminobutyrate to form felodipine.

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