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Pharmaceutical Heparin Lithium raw Powder
Product Overview:
Lithium heparin is a chemical with a white to white powder appearance. There was no significant difference in the detection results of TP, ASO, UA, ALT, Mg, Cl, TC and CRP between heparin lithium anticoagulant plasma and serum (P>0.05). The results of HBD, LDH and TBA in heparin lithium anticoagulant plasma and serum were significantly different (P<0.05). Therefore, except HBD, LDH and TBA, the correlation between heparin lithium anticoagulant plasma and serum is better. Therefore, it is feasible to use heparin lithium anticoagulant plasma instead of serum in life detection, and it can be used as an important detection method.
Pharmaceutical Heparin Lithium raw Powder Attributes
CAS:9045-22-1
MF:C12H4Cl2F6N4OS
MW:437.15
EINECS:424-610-5
Specification: 99% min Heparin Lithium
Sample:Heparin Lithium Powder
Packaging:1kg/bag, 25kg/drum
Brand: Henrikang
Appearance:white
Storage: Cool Dry Place
Shelf Life: 2 Years
Test Method: HPLC
Pharmaceutical Heparin Lithium raw Powder Details
Commonly used heparin anticoagulant, heparin sodium, potassium, lithium, ammonium salts, of which heparin lithium is the best.
Uses of Heparin Lithium.
Preparation of Heparin Lithium.
1) Crude heparin enzymolysis: dissolve crude heparin sodium, adjust the PH value to 7.5‑9.0, temperature to 50‑55℃, add heparin enzymolysis pancreas enzyme, heat for 4‑5 hours, adjust the PH value 9.0‑11, temperature rise to 85-90℃, cool, filter to remove the sediment, filtrate with ethanol precipitation, collect the sediment (A);
2) Deprotein: Step 1 The resulting precipitate (A) is dissolved in water, stirred, adjusted PH to 9-11, added protein flocculating precipitator, stirred, left, filtered to remove precipitate, collected filtrate (D), adjusted PH to 11-13, stirred, left, filtered to remove precipitate, collected filtrate (E), adjusted PH to neutral, precipitated with ethanol, Collection of sediment (B);
3) Oxidation and decolorization: the sediment obtained in step 2 (B) is dissolved in water, oxidized with hydrogen peroxide for 24‑48 hours, adjusted PH to 10.5‑11.5, filtered to remove the sediment, collect the filtrate (F), adjust the PH value of the filtrate (F) to 6.5‑7.5, precipitate with ethanol, collect the sediment (C);
4) Resin exchange: Dissolve the precipitate (C) obtained in step 3 with water, add LiCl, stir to dissolve, carry out ion exchange through the resin column, collect the effluent from the column, and obtain heparin lithium solution;
5) Precipitation, dehydration and drying: the lithium heparin solution obtained in step 4 is filtered, precipitated with ethanol, the sediment (G) is collected, the sediment (G) is dehydrated, and then vacuum dried and crushed to obtain the lithium heparin fine.
Product method of Heparin Lithium.
