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Glimepiride raw Materials Powder
Product Overview:
Glimepiide is the third generation sulfonylurea long-acting anti-diabetic drug, the main mechanism of its hypoglycemic effect is to stimulate the secretion of insulin by islet beta cells, and partially improve the sensitivity of surrounding tissues to insulin. It binds and dissociates insulin receptors faster than glibenclamide and is less likely to cause severe hypoglycemia. The mechanism of action is through binding to the sulfonyluurea receptor (a protein with a relative molecular weight of 6.5×104) on the surface of pancreatic β-cells, which is coupled with the ATP-sensitive K+ (KATP) channel, promoting the closure of KATP channel, causing the depolarization of cell membrane, opening the voltage-dependent calcium channel, and promoting the release of insulin through Ga2+ internal flow. And inhibit liver glucose synthesis
Glimepiride raw Materials Powder Attributes
CAS:93479-97-1
MF:C24H34N4O5S
MW:490.62
EINECS:642-919-5
Specification: 99% min Glimepiride Powder
Sample:Glimepiride Powder
Packaging:1kg/bag, 25kg/drum
Brand: Henrikang
Appearance:White
Storage: Cool Dry Place
Shelf Life: 2 Years
Test Method: HPLC
Glimepiride raw Materials Powder Details
Glimepiride Powder Usage and Synthesis.
Glimepiride can improve blood glucose control in type 2 diabetes patients, and its efficacy is similar to that of other second-generation sulfonylureas. However, glimepiride only needs to be taken once a day and is well tolerated. Glimepiride is a convenient and safe alternative sulfonylurea for type 2 diabetes patients who simply use diet and exercise to treat poor blood glucose control. In type 2 diabetes patients with secondary failure of sulfonylureas, glimepiide combined with insulin can reduce the dose of exogenous insulin. At present, studies suggest that glimepiride is well tolerated, but more information is needed on the use of glimepiride in combination with other hypoglycemic agents. Glimepiride only needs to be taken once at breakfast, which is convenient and easy, and the efficacy is certain, the interaction between drugs is less, and the side effects are relatively mild, so the application prospect is optimistic.
Uses of Glimepiride.
Pharmacological action of Glimepiride.
Product Method of Bulk Glimepiride Powder.
3-ethyl-2, 5-dihydro-4-methyl-2-oxygen-1H-pyrrole reacts with phenyl ethyl isocyanate, then chlorosulfonates with chlorosulfonic acid, amolysis to sulfonamide, and finally condensation with isocyanate p-methylcyclohexyl ester, resulting in a product. Or the product of chlorosulfonation first reacts with methyl carbamate, and then condensates with p-methylcyclohexylamine, the product can also be obtained.
