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Fasudil hydrochloride Raw Materials powder
Product Overview:
Fasudil hydrochloride is a new drug with a wide range of pharmacological effects, which was first developed by Asahi Kasei Company in Japan and first launched in Japan in June 1995. In 2001, China approved Japan's Asahi Kasei Company to import Fasudil hydrochloride injection, the product name "Iriru". Its molecular structure is 5-isoquinoline sulfonamide derivative, which is a RHO kinase inhibitor. By increasing the activity of myosin light chain phosphatase, it dilates blood vessels, reduces the tension of endothelial cells, improves the microcirculation of brain tissue, does not produce or aggravate the brain theft of blood, and can antagonize inflammatory factors, protect nerve against apoptosis and promote nerve regeneration. Fasudil hydrochloride has a certain effect on promoting the recovery of nerve function, alleviating clinical symptoms and reducing the rate of disability
Fasudil hydrochloride Raw Materials powder Attributes
CAS:105628-07-7
MF:C14H18ClN3O2S
MW:327.83
EINECS:805-833-0
Specification: 99% min Fasudil hydrochloride powder
Sample:Fasudil hydrochloride powder
Packaging:1kg/bag, 25kg/drum
From:Henrikang
Appearance:white
Shelf Life: 2 Years
Test Method: HPLC
Fasudil hydrochloride Raw Materials powder Details
Fasudil hydrochloride powder Usage and Synthesis.
Fasudil hydrochloride has a certain effect on promoting the recovery of nerve function, alleviating clinical symptoms and reducing the rate of disability. Therefore, at the grass-roots level, due to the constraints of economic conditions and the degree of understanding of the disease, ultra-early thrombolytic therapy cannot be realized, but in order to reduce the further progress of the disease, it is crucial to rebuild local blood circulation within the treatment time window. Fasudil hydrochloride has significant neuroprotective and therapeutic effects on ischemic cerebrovascular diseases, and is worthy of clinical use, especially at the grass-roots level. Reduce disability rates and improve quality of life.
Uses of Fasudil hydrochloride powder.
A potent Rho kinase inhibitor and vasodilator. It also has inhibitory activity on PKA, PKG, PKC and MLCK. Cardiovascular and cerebrovascular drugs are used to improve the symptoms of ischemic cerebrovascular diseases caused by cerebral vasospasm after subarachnoid hemorrhage.
Pharmacological action of Fasudil hydrochloride.
Fasudil hydrochloride is a derivative of isoquinoline sulfanilamide, which can not only inhibit the activity of intracellular free calcium ions, but also inhibit protein kinase A.G.C and myoglobulin light chain kinase, that is, inhibit smooth muscle contraction, the final stage of myosin light chain phosphorylation, so that vascular smooth muscle relaxation, dilate blood vessels. In vitro experiments show that this product can relax the isolated cerebral vessels, inhibit the in vitro vasoconstriction caused by calcium ion flow, inhibit the contractile effect of various cerebrovascular contractile drugs, inhibit intracellular calcium ion and vasoconstriction effect, but does not reduce the intracellular calcium ion concentration and inhibit the generation of myosin light chain phosphate during vasoconstriction. It is used to improve and prevent cerebral vasospasm and cerebral ischemia after subarachnoid hemorrhage. Administer 30mg once by intravenous drip, 2-3 times a day. This drug is used in the early stage after subarachnoid hemorrhage, and is generally used for 2 weeks.
Product method of Bulk Fasudil hydrochloride powder.
