Raw Materials powder Fasudil hydrochloride

CAS:105628-07-7

MF:C14H18ClN3O2S

MW:327.83

EINECS:805-833-0

Specification​: 99% min Fasudil hydrochloride powder

Sample:Fasudil hydrochloride powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance:white

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Fasudil hydrochloride powder Usage and Synthesis.

Fasudil hydrochloride has a certain effect on promoting the recovery of nerve function, alleviating clinical symptoms and reducing the rate of disability. Therefore, at the grass-roots level, due to the constraints of economic conditions and the degree of understanding of the disease, ultra-early thrombolytic therapy cannot be realized, but in order to reduce the further progress of the disease, it is crucial to rebuild local blood circulation within the treatment time window. Fasudil hydrochloride has significant neuroprotective and therapeutic effects on ischemic cerebrovascular diseases, and is worthy of clinical use, especially at the grass-roots level. Reduce disability rates and improve quality of life.

Uses of Fasudil hydrochloride.

Cardiovascular and cerebrovascular drugs are used to improve the symptoms of ischemic cerebrovascular diseases caused by cerebral vasospasm after subarachnoid hemorrhage. A potent Rho kinase inhibitor and vasodilator. It also has inhibitory activity on PKA, PKG, PKC and MLCK.

Pharmacological action of Fasudil hydrochloride.

Fasudil hydrochloride is a derivative of isoquinoline sulfanilamide, which can not only inhibit the activity of intracellular free calcium ions, but also inhibit protein kinase A.G.C and myoglobulin light chain kinase, that is, inhibit smooth muscle contraction, the final stage of myosin light chain phosphorylation, so that vascular smooth muscle relaxation, dilate blood vessels. In vitro experiments show that this product can relax the isolated cerebral vessels, inhibit the in vitro vasoconstriction caused by calcium ion flow, inhibit the contractile effect of various cerebrovascular contractile drugs, inhibit intracellular calcium ion and vasoconstriction effect, but does not reduce the intracellular calcium ion concentration and inhibit the generation of myosin light chain phosphate during vasoconstriction. It is used to improve and prevent cerebral vasospasm and cerebral ischemia after subarachnoid hemorrhage. Administer 30mg once by intravenous drip, 2-3 times a day. This drug is used in the early stage after subarachnoid hemorrhage, and is generally used for 2 weeks. At the time of administration, it was diluted by 50 to 100mLNS or GS and intravenous drip for 30 minutes each time. Appropriate reduction in renal insufficiency, such as 10mg once. The adverse reactions may include intracranial hemorrhage, digestive tract hemorrhage, pulmonary hemorrhage, nasal hemorrhage, subcutaneous hemorrhage, and consciousness disturbance. And abnormal liver function. Occasionally, hypotension, anemia, leukopenia, abnormal renal function, polyuria, rash, fever, etc. Patients with intracranial hemorrhage and potential intracranial hemorrhage and patients with hypotension should be contraindicated. Before operation, patients with diabetes mellitus, arteriosclerosis of the main cerebral artery, severe disturbance of consciousness, subarachnoid hemorrhage combined with cerebrovascular disorders, liver and kidney insufficiency, patients over 70 years old, pregnant women and children should be used with caution. Lactating women should stop breastfeeding when taking medication. This drug can only be administered intravenously, not by other means

Product method of Bulk Fasudil hydrochloride.