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Nitrendipine raw Materials Powder
Product Overview:
Nirendipine is a second-generation dihydropyridine calcium antagonist, which is the most clinically studied among the four common dihydropyridine calcium antagonists (nifedipine, amlodipine, felodipine), and is mainly used for the treatment of hypertension and coronary heart disease in the elderly. We know that the current routine treatment for hypertension is to combine guanethidine sulfate (antihypertensive drug) with dihydroquemide (diuretic drug). On the one hand, dihydroquemide reduces blood volume and cardiac output through sodium diuresis, and on the other hand, it can directly inhibit vascular smooth muscle, dilate blood vessels, reduce peripheral vascular resistance and lead to a decrease in blood pressure. Therefore, combined with guanethidine sulfate can enhance the antihypertensive effect and reduce the occurrence of edema. However, dihydrocresuloxide discharged more potassium, easy to cause hypokalemia, and if the combination of nirendipine and dihydrocresuloxide can avoid hypokalemia. Because this product is excreted by sodium in the urine, it not only helps patients to reduce blood pressure, but also has the effect of inhibiting the release of aldosterone, so it does not cause hypokalemia.
Nitrendipine raw Materials Powder Attributes
CAS:39562-70-4
MF:C18H20N2O6
MW:360.36
EINECS:254-513-1
Specification: 99% min Nitrendipine Powder
Sample:Nitrendipine Powder
Packaging:1kg/bag, 25kg/drum
Brand: Henrikang
Appearance:yellow
Storage: Cool Dry Place
Shelf Life: 2 Years
Test Method: HPLC
Nitrendipine raw Materials Powder Details
Drug interaction of Nitrendipine Powder.
(1) It can increase the plasma concentration of digitalis, such as digoxin, by about 45% on average.
(2) beta-blocker: the vast majority of patients with the combination of this drug can strengthen the antihypertensive effect, and can reduce the tachycardia occurred after the product antihypertensive; However, individual patients may induce and aggravate systemic hypotension, heart failure, and angina pectoris.
(3) The combination of angiotensin-converting enzyme inhibitors was well tolerated and the antihypertensive effect was enhanced.
(4) Cimetidine can mediate the inhibition of liver cytochrome P450 enzyme, so that the first pass effect of nirendipine can be changed, and it is recommended to pay attention to the adjustment of drug dosage for patients who are taking cimetidine treatment with nirendipine.
Uses of Nitrendipine.
The second generation calcium antagonist is an ideal drug for the treatment of hypertension. It has significant and lasting antihypertensive and vasoconstrictive effects. It is suitable for various types of hypertension, such as primary and secondary mild and moderate hypertension, and can also be used for coronary heart disease, congestive heart failure and so on.
Pharmacological action of Nitrendipine.
Nitrendipine is used to treat hypertension, congestive heart failure, and hypertension with angina. It can selectively act on the calcium channels of vascular smooth muscle, inhibit the transmembrane calcium ion flow between vascular smooth muscle and myocardium, and has a greater affinity for blood vessels than myocardium, and a stronger selective effect on coronary arteries. The order of artery dilation intensity is coronary artery > femoral artery > renal artery > pulmonary artery. It can reduce myocardial oxygen consumption and protect ischemic myocardium. It can reduce total peripheral resistance and lower blood pressure.
Product Method of Bulk Nitrendipine Powder.
The acid catalyzed condensation of m-nitrobenzaldehyde and ethyl acetoacetate gives 2-(3-nitrobenzylidene) ethyl acetoacetate. 2-(3-nitrobenzyl) ethyl acetoacetate and 3-aminobutyrate methyl ester were placed in Soxlet extractor flask, anhydrous ethanol was added, and the siphon of Soxlet extractor was filled with filter paper wrapped molecular sieve, and then placed overnight after being heated in a water bath and refluxed for 4h. The crystallization was recrystallized with 5 times the amount of anhydrous ethanol to obtain Nitrendipine pure product with melting point of 158 ~ 159℃ and yield of 90.8%. Without molecular sieve, the yield was 86.1%.
