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  • Trospium Chloride Raw Material Powder

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    Product Overview:

    China Trospium Chloride Raw Material Trospium Chloride Powder Factory Supply Trospium Chloride Raw Material, High Quality Trospium Chloride Powder Purity 99% Trospium Chloride Raw Powder CAS 10405-02-4 Trospium Chloride Raw Powder is used for the treatment of urinary frequency, urgency and urge incontinence due to instability of the urethral muscle or hyperreflexia of the urethral muscle.

    Trospium Chloride Raw Material Powder Attributes

    Trospium Chloride Raw Material Powder

    CAS: 10405-02-4

    MF: C25H30ClNO3

    Trospium chloride Powder

    MW:427.96

    EINECS: 233-875-4

    Specification​: 99% min Trospium Chloride

    Sample: Trospium Chloride Powder

    Packaging:1kg/bag, 25kg/drum

    Brand: Henrikang

    Appearance: White Powder

    Storage: Cool Dry Place

    Shelf Life: 2 Years

    Test Method: HPLC

    Trospium Chloride Raw Material Powder Details

    Trospium Chloride Raw Materials Usage and Synthesis

    China Trospium Chloride Raw Material Trospium Chloride Powder Factory Supply Trospium Chloride Raw Material, High Quality Trospium Chloride Powder Purity 99% Trospium Chloride Raw Powder CAS 10405-02-4 Trospium Chloride Raw Powder is used for the treatment of urinary frequency, urgency and urge incontinence due to instability of the urethral muscle or hyperreflexia of the urethral muscle.

    Trospium Chloride Powder

    Uses and functions of Trospium Chloride Powder

    Trospium chloride is a synthetic tropic acid derivative with four ammonium groups, belongs to the parasympathetic nerve blocking drug, the action is similar to atropine, mainly through the endogenous neurotransmitter acetylcholine competitive binding postsynaptic membrane M receptor and action.

    It can reduce parasympathetic tension and remove smooth muscle spasm caused by parasympathetic nerves in organs innervated by parasympathetic nerves, and it also has a certain effect on the gastrointestinal, biliary and urinary tracts.

    Trospium Chloride Raw Powder

    The product has low fat solubility and cannot easily pass the blood-brain barrier, so it will not produce central nervous system side effects.

    Pharmacological Effects of Trospium Chloride Raw Powder

    • 1. Enhance the anticholinergic effects of drugs such as amantadine, tricyclic antidepressants, quinidine, antihistamines and verapamil; enhance the cardiac accelerating effects of sympathomimetic drugs; and reduce the orthodynamic effects of drugs such as metoclopramide and cisapride.
    • 2. Since this product may affect the dynamics and secretion of the gastrointestinal tract, it cannot be excluded that this product may affect the absorption of other drugs taken at the same time.
    Trospium Chloride Raw Materials
    • 3. Since it cannot be excluded that drugs such as guar gum and cholestyramine inhibit the absorption of this product, the use of these drugs with this product is not recommended.
    • 4. In vitro tests have shown that this product affects the metabolism of cytochrome enzymes P450 related to drug metabolism (CYP1A2, 2A6, 2C9, 2C19, 2D19, 2D6, 2E1, 3A4). No effect on other metabolism.

    Production method of Raw Trospium Chloride Powder

    Tropine is acylated and hydrolysed to form nortropine, which reacts with 1,4-dichlorobutane to form (3q-nortropine)-8-spiro-1'-pyrrolyl ammonium chloride, which then reacts with diphenylglycolic acid-activated amide to form trichlormethonium chloride under the catalysis of DMAP.

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