Pharmaceutical veterinary medicine thiamphenicol Powder

CAS:15318-45-3

MF:C12H15Cl2NO5S

MW:356.22

EINECS:239-355-3

Specification: 99% min thiamphenicol Powder

Sample:thiamphenicol Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance: White Powder

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

thiamphenicol Powder Usage and Synthesis.

Thiamphenicol is a chloramphenicol broad-spectrum antimicrobial agent, which has a stronger effect on gram-negative bacteria than on positive bacteria. It is white to off-white crystalline powder or crystals at room temperature, which can be absorbed rapidly and completely when taken orally, and metabolically it is mainly excreted from urine in its original form. Clinically, it is mainly used in the treatment of respiratory, urinary, hepatobiliary, typhoid fever and other intestinal surgery, obstetrics and gynaecology and pentacameral infections, especially for mild infections, especially obvious.

Clinically, it is mainly used in the treatment of respiratory, urinary, hepatobiliary, typhoid fever and other intestinal surgery, obstetrics and gynaecology and pentacameral infections, especially for mild infections, especially obvious.

The chemical structure is similar to chloramphenicol, and its methyl sulfone group replaces the nitro group of chloramphenicol, thus reducing the toxicity of its in vivo antibacterial effect is 2.5-5 times stronger than that of chlorotoxin.

It has strong antibacterial effect on Gram-positive bacteria such as pneumococcus, haemolytic streptococcus, Gram-positive bacteria such as gonococcus, meningococcus, pneumococcus, Escherichia coli, Vibrio cholerae, dysentery bacillus and Influenza bacillus, etc. It has certain antibacterial effect on anaerobic bacillus, rickettsiae, amoebae and so on, and the mechanism of its action is same as that of chloramphenicol.

Mainly inhibit the synthesis of bacterial protein, the drug oral absorption fast, in 2 hours the blood concentration can reach the highest peak, half-life of 5 hours, than chloramphenicol lasting, the bacteria on the product and chloramphenicol and chloramphenicol have a complete cross-resistance, on the product and tetracycline drugs have a part of the phenomenon of cross-resistance.

Uses and functions of thiamphenicol.

Thiamphenicol is a broad-spectrum bacteriostatic agent. It has an inhibitory effect on most Gram-positive and Gram-negative bacteria.

Especially for gram-negative bacilli, such as Escherichia coli, Salmonella, typhoid fever, aerobic bacilli, Klebsiella, Bartonella, Brucella, dysentery bacilli, etc., gram-positive bacteria such as anthrax, staphylococcus, corynebacterium, pneumococcus, streptococcus, enterococci, and actinomycetes, which are also more sensitive to the role of the bacterium.

However, it is not as effective as penicillin and tetracycline against Gram-positive bacteria. It is also effective against Leptospira, some mycoplasmas, some chlamydia and rickettsiae. There is complete cross-resistance between this product and chloramphenicol, and partial cross-resistance with tetracyclines.

Physiological Effect of thiamphenicol.

Thiamphenicol is the analogue of chloramphenicol, the antibacterial spectrum and antibacterial effect is similar to chloramphenicol, with a broad-spectrum anti-microbial effect, including aerobic gram-negative and gram-positive bacteria, anaerobic bacteria, Rickettsiae spp., spirochetes and Chlamydiae spp.

1、Methylsulfonylmethamphetamine has bactericidal effect on the following bacteria: Haemophilus influenzae, Streptococcus pneumoniae and Neisseria meningitidis.

2、It is only bacteriostatic for the following bacteria: Staphylococcus aureus, Streptococcus pyogenes, Streptococcus grasshopperus, group B haemolytic streptococcus, Escherichia coli, Klebsiella pneumoniae, Streptococcus pyogenes, Salmonella typhi, Salmonella paratyphi, Shigella spp. and anaerobic bacteria such as Bacteroides fragilis.

3, the following bacteria are usually resistant to chloramphenicol: Pseudomonas aeruginosa, Pseudomonas aeruginosa, Enterobacteriaceae, Serratia marcescens, indole-positive Proteus spp, methicillin-resistant staphylococci and Enterococcus spp.

4, Thiamphenicol is a bacteriostatic agent, reversibly binds to the 50S subunit of bacterial ribosomes, blocking the growth of peptide chains (probably due to the inhibition of the action of transpeptidases), thus inhibiting the formation of peptide chains and thus preventing protein synthesis, and chloramphenicol is completely cross-resistant to each other. Since methicillin does not bind to glucuronic acid in the liver, it has high antibacterial activity in vivo. It also has strong immunosuppressive effects.

Adverse Reaction of  Bulk thiamphenicol Powder.

1、Abdominal pain, diarrhoea, nausea, vomiting and other gastrointestinal reactions may occur, the incidence of which is less than 10%.

2. Occasionally, allergic reactions such as skin rashes are seen.

3, premature infants and newborns have not been found in the "grey baby syndrome", only one case reported transient skin and pallor.

4、It can cause toxic reaction of haematopoietic system, mainly manifested as reversible inhibition of erythropoiesis, reduction of leukocytes and platelets, and the occurrence of aplastic anaemia is rare.

5, the central nervous system reaction mainly manifested as headache, drowsiness, dizziness and peripheral neuritis. Long-term treatment with methylsulfonylmethoxazole in people with neurological lesions can cause symptoms such as hyperalgesia, pain on touch and nociception. Symptoms are more severe in the feet than in the hands and may improve after discontinuation of the drug, but not completely.