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  • Pharmaceutical raw material Norfloxacin Powder

    • Pharmaceutical raw material Norfloxacin Powder
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    Product Overview:

    Norfloxacin, also known as haloperidol, is a commonly used medicine for treating intestinal infections. Especially in summer and autumn, due to the rapid reproduction of bacteria and easy spoilage of food, many people suffer from bacterial infectious diarrhoea due to unclean diet. Norfloxacin tends to become a common medicine at home or a common medicine for travelling.
    Norfloxacin has high antibacterial activity against Gram-negative bacteria such as Escherichia coli, dysentery bacillus, Salmonella, Aspergillus, Pseudomonas aeruginosa, etc. It also has good antibacterial effect against Gram-positive bacteria such as Staphylococcus and S. pneumoniae.

    Pharmaceutical raw material Norfloxacin Powder Attributes

    Pharmaceutical raw material Norfloxacin Powder

    CAS:70458-96-7

    MF: C16H18FN3O3

    Norfloxacin raw material

    MW:319.33

    EINECS:274-614-4

    Specification​: 99% min Norfloxacin Powder

    Sample:Norfloxacin Powder

    Packaging:1kg/bag, 25kg/drum

    Brand: Henrikang

    Appearance: White to Yellow Powder

    Storage: Cool Dry Place

    Shelf Life: 2 Years

    Test Method: HPLC

    Pharmaceutical raw material Norfloxacin Powder Details

    Norfloxacin Powder Usage and Synthesis.

    Norfloxacin, also known as haloperidol, is a commonly used medicine for treating intestinal infections. Especially in summer and autumn, due to the rapid reproduction of bacteria and easy spoilage of food, many people suffer from bacterial infectious diarrhoea due to unclean diet. Norfloxacin tends to become a common medicine at home or a common medicine for travelling.

    Norfloxacin has high antibacterial activity against Gram-negative bacteria such as Escherichia coli, dysentery bacillus, Salmonella, Aspergillus, Pseudomonas aeruginosa, etc. It also has good antibacterial effect against Gram-positive bacteria such as Staphylococcus and S. pneumoniae.

    The main role in the bacterial DNA promoter enzyme, so that the bacterial DNA helix cleavage, rapid inhibition of bacterial growth and reproduction, killing bacteria, and the cell wall has a strong penetration effect, so its bactericidal effect is stronger and less stimulation of the gastric mucosa.

    Norfloxacin Powder

    Uses and functions of Norfloxacin.

    Haloperidol Chang is a third-generation quinolone antimicrobial agent developed by Apricot Grove in Japan in 1978. It has a wide antibacterial spectrum and strong antibacterial power. On the Escherichia coli, pneumococcus, gas-producing bacilli, inguinal bacilli, Aspergillus, Salmonella spp., Shigella spp., Citrobacter spp. and Serratia spp. and other remote phytophthora spp. bacteria have a strong antimicrobial effect.

    Linqing is used for sensitive bacteria caused by the urinary system, intestinal tract, hu suction system, surgery, gynaecology, gynecology and dermatology and other infectious diseases. It is also used in the treatment of gonorrhoea.

    It has broad-spectrum and efficient antibacterial effect, wide therapeutic range, good oral absorption, low toxicity, and is mainly used in the treatment of urinary tract infection, biliary tract infection, intestinal tract infection, with remarkable efficacy.

    Norfloxacin raw material

    Pharmacological Effects Norfloxacin.

    Norfloxacin and ofloxacin, levofloxacin, ciprofloxacin belong to the third generation of fluoroquinolone antimicrobial drugs, with broad-spectrum antibacterial effect, especially for aerobic gram-negative bacilli antibacterial activity is high, for the following bacteria in vitro with good antibacterial effect: most of the bacteria in the family of Enterobacteriaceae, including Bacillus bacillus genus, enterobacteriaceae, Enterobacteriaceae and other Enterobacteriaceae, Escherichia coli, Klebsiella spp. and Proteus spp, Salmonella, Shigella, Vibrio, and Yersinia.

    Norfloxacin also has antibacterial activity against multi-drug resistant bacteria in vitro. Penicillin-resistant Neisseria gonorrhoeae, Haemophilus influenzae and Catamonas also have good antibacterial effect. Norfloxacin is a bacteriostatic agent, which inhibits DNA synthesis and replication by acting on the A subunit of bacterial DNA helicase, leading to bacterial death.

    Norfloxacin Raw Powder

    Production method of Bulk Norfloxacin Powder.

    3,4-Dichloronitrobenzene is obtained by nitration of o-dichlorobenzene or chlorination of p-nitrochlorobenzene. In dimethyl sulphoxide and potassium fluoride, 3-chloro-4-fluoronitrobenzene is refluxed and fluorinated. In the presence of aqueous hydrochloric or acetic acid, 3-chloro-4-fluoroaniline was reduced with iron powder.

    This is then refluxed with triethyl orthoformate and diethyl malonate (to yield diethyl ethoxymethylene malonate) in the presence of ammonium nitrate to give the condensation product. Heated cyclisation in liquid paraffin or diphenyl ether produces ethyl 7-chloro-6-fluoro-4-hydroxyquinoline-3-carboxylate. Ethylation was carried out and then hydrolysed to give the ethylated product.

    Finally condensed with piperazine to obtain norfloxacin. Its process is relatively mature, the yield is high, generally can reach 40% to 65%, but when the piperazine group is introduced in the 7 position, the by-product of the 6 fluorine atom being replaced can account for 25%, which is difficult to separate and affects the yield. The total yield of p-nitrochlorobenzene is more than 8 per cent.

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