Pharmaceutical intermediates Bulk L - Alanine Powder

CAS:56-41-7

MF: C3H7NO2

MW: 89.09

EINECS:200-273-8

Specification​: 99% min L - Alanine Powder

Sample:L - Alanine Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance:White Powder

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

L - Alanine Powder Usage and Synthesis.

L-Alanine is colourless to white crystalline powder, soluble in water, ethanol, insoluble in ether and acetone. Mainly used in biochemical research, tissue culture, liver function determination, flavour enhancer, can increase the flavouring effect of condiments, can also be used as acidity correcting agent, improve the acidity of organic acids.

Uses and functions of L - Alanine.

Nutritional supplements. It is a non-essential amino acid, which is the most abundant one in the blood and has important physiological roles. Flavouring agent. Used in unfermented products, synthetic sake, compound sweeteners, etc., it has obvious synergistic effect, and the dosage is generally 0.01% to 0.03%. React with sugar by heating (aminocarbonyl reaction), it can generate special flavour substances.

This product is the raw material for manufacturing vitamin B6, synthetic calcium pantothenate and other organic compounds. It can be added to foodstuffs to enhance the flavouring effect of chemical seasonings, improve the taste of sweeteners and the acidity of organic acids, improve the quality of alcoholic beverages, prevent the oxidation of oils and improve the flavour of impregnated foodstuffs. It can also be used as biochemical reagent for biochemical and microbiological research.

Characteristic of L - Alanine.

White crystal or crystalline powder, no strange odour, with sweet taste. Easily soluble in water(16.5%,25℃),insoluble in ether or acetone. Decomposition temperature is 297℃>, mp233℃, isoelectric point 5.79, pka-COOH=2.34,Pka-NH3=9.60,[α]25D+14.6(C=0.5~2.0g/ml,5mol/LHCl).

L-alanine is a non-essential amino acid that is formed in organisms by the transfer of the amino group of glycine to pyruvate. In the glucose-alanine cycle, low blood ammonia levels are maintained. Alanine is an excellent transporter of nitrogen in the blood. It is also an effective gluconeogenic amino acid.

Production Method of Bulk L - Alanine Powder.

1.Propionic acid chlorination and ammoniation method is made of propionic acid as raw material, under the temperature of 105℃ and the presence of 3% red phosphorus catalyst, liquid chlorine is passed in for chlorination, which generates 2-chloro propionic acid, and then it is put into ammonia solution, and then it is ammoniated under the temperature of 60℃ with urotropine as catalyst, which generates 2-amino propionic acid. Finally, the reactants were sent into methanol solution for crystallisation, and the finished product of α-alanine was produced by centrifugation and drying.

2.α-Bromopropionic acid chlorination method will be α-bromopropionic acid, ammonia, ammonium bicarbonate mixed with stirring and reflux for 7h, and then evaporated to dryness, and then ethanol soak to wash away the ammonium bromide, filtration out of the crystals, and then filtered by decoloration and adding ethanol to get the crystals, filtering and drying to get the finished product.

3.Cyanohydrin method: acetaldehyde reacts with hydrocyanic acid to produce cyanohydrin, then reacts with ammonia to get aminonitrile; then hydrolyse under alkaline condition to produce sodium aminopropionate, and then get α-alanine by ion exchange.