β-Alanine raw materials β-Ala Powder

CAS:107-95-9

MF:C6H14N2O2

MW:89.09

EINECS:203-536-5

Specification: 99% min β-Ala Powder

Sample:β-Ala Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance: Light White Powder

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

β-Ala Powder Usage and Synthesis.

β-Alanine is an organic compound with the molecular formula C3H7NO2, colourless crystals, soluble in water, slightly soluble in ethanol, insoluble in ether and acetone. The β-alanine produced by biological method contains acidic flavour.

Mainly used in the synthesis of medicine and feed additives calcium pantothenate raw materials, can also be used in the production of electroplating corrosion inhibitors, used as biological reagents and organic synthesis intermediates. Used as food and health care additives.

Uses and functions of β-Ala.

Endogenous beta-amino acid, non-selective glycine receptor agonist, G-protein coupled orphan receptor (TGR7, MrgD) ligand. Dependent on supporting osmotic stabilisation in marine organisms, beta-amino acid efflux acts as a cytoprotective agent.

β-Alanine is mainly used as a raw material for the synthesis of calcium pantothenate for pharmaceuticals and feed additives, and can also be used in the production of electroplating corrosion inhibitors, as biological reagents and organic synthesis intermediates. Used as food and health care additives.

Characteristic of β-Ala.

1. Avoid contact with strong oxidising agents.

2. β-alanine is non-toxic, but contact with eyes and skin should be avoided.

3. Present in tobacco, smoke.

Production Method of  Bulk β-Ala Powder.

1、Acrylonitrile reacts with ammonia in diphenylamine and tert-butanol solution to produce β-aminoacrylonitrile, which is then obtained by alkaline decomposition. Add acrylonitrile, diphenylamine and tert-butanol sequentially in a dry autoclave with stirring for 5min, add liquid ammonia, control the temperature at 100-109 ℃, the pressure at about 1MPa, keep warm and stirring for 4h. Stop stirring when cooling to below 10 ℃, and the pressure drops to atmospheric pressure.

At 65-70℃/(8.0-14.7kPa), recover the tert-butanol under reduced pressure to get the crude β-aminopropionitrile, the crude product was then distilled under reduced pressure, and the 66-105℃/(1.33-4.0kPa) fraction was collected to get β-aminopropionitrile. The alkali decomposition operation was carried out in the reaction tank, firstly put in liquid alkali, control the temperature 90-95℃, slowly add β-aminopropionitrile under stirring, after adding, keep warm for 1 h. Evaporate for half an hour under reduced pressure to drive off ammonia in the reaction solution, add appropriate amount of water, dropwise addition of hydrochloric acid to pH7-7.2.

Filter, remove a small amount of insoluble impurities.

The filtrate is concentrated under reduced pressure until a large number of solids precipitated, while hot out of the material, cooled to below 10 ℃, filtration, vacuum drying, to get β-alanine. This method consumes 982kg of β-aminopropionitrile per tonne of product, and the yield is 90% in alkaline decomposition stage.

2, from the succinimide degradation (Huo's reaction) and the alkaline sodium hypochlorite solution (containing 14% sodium hypochlorite, 8% sodium hydroxide, sodium carbonate 30%) and ice into the reaction tank, stirring to add succinimide, at 18-25 ℃ reaction 0.5h. Temperature rise to 40-50 ℃ reaction 1h.

Add hydrochloric acid to adjust to pH4-5, concentrated under reduced pressure. After the concentrate was cooled, 3 times the amount of 95% ethanol was added to precipitate inorganic salts, filtered, and then repeated once. Then the filtrate was diluted with 4 times the amount of distilled water and refluxed for 1h.

Activated carbon was added to decolourise, filtered, and the filtrate was exchanged through an exchange resin. The obtained exchange solution plus activated carbon decolourisation, filtration, filtrate concentration under reduced pressure, cooling crystallisation, filtration, recrystallisation with distilled water for 1 time, β-aminopropionic acid. 3, β-aminopropionitrile method by β-aminopropionitrile hydrolysis, acid precipitation and obtained.