Pharmaceutical raw material Levamisole Hcl

CAS:16595-80-5

MF:C11H13ClN2S

MW:240.75

EINECS:240-654-6

Specification: 99% min Levamisole Hcl Powder

Sample:Levamisole Hcl Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance: White Powder

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Levamisole Hcl Powder Usage and Synthesis.

Levamisole can regulate the immune function, mainly on T lymphocytes, to induce early differentiation and maturation of T cells into functional T cells, thus promoting the normal function of T cells ht can also strengthen the phagocytosis and chemotaxis of macrophages to improve the activity of natural killer cells, produce endogenous interferon, improve the immune function so that it is normal, effectively preventing the progression of the pneumonia disease, improve the cough, lung sounds and other symptoms. Symptoms.

In addition, after the weakening of the immune function of the child, by taking levamisole hydrochloride, it can increase the total complement content in the blood, especially increase the production of IgG, IgA, so as to improve the immune effect of the respiratory tract membranes, and play the role of viral resistance and prevention of bacterial infection.

Levamisole can both regulate and restore immunity, and it can show two-way regulation for abnormal humoral immune function, make it tend to normal development, and help the low cellular immune function to return to normal.

Uses and functions of Levamisole Hcl.

Levamisole hydrochloride is an anthelmintic. Levamisole is about twice as active as the eliminators and has lower toxicity and side effects. Levamisole can paralyse the muscle of Ascaris lumbricoides and then excreted in the faeces. It is mainly used for anti-roundworm and anti-hookworm.

The product is an anthelmintic. The activity of levamisole is about twice as much as that of the eliminators, and the toxicity and side effects are also lower. Levamisole can paralyse the muscle of Ascaris lumbricoides and then excreted with faeces. It is mainly used for anti-roundworm and anti-hookworm.

Preparation of Levamisole Hcl.

Put a certain amount of concentrated hydrochloric acid in a beaker, slowly add the stoichiometric ratio of 1:6 rare earth yttrium oxide, stirring until a light yellow, clear and transparent liquid.

The solution was placed in a rotary evaporator and heated until the viscosity thickened and the colour darkened, and then transferred to a crucible to continue heating to obtain white yttrium chloride solid.

LH and yttrium chloride were dissolved in distilled water and anhydrous ethanol, and the dissolved yttrium chloride ethanol solution was slowly added to the LH aqueous solution dropwise at a certain ratio, the reaction temperature was 25 degrees Celsius, and the reaction time was 50 min.

After the reaction was completed, the mixture was transferred to a rotary evaporator for heating and concentration, and after cooling, a large amount of acetone was added and left to stand for 24h, white crystals were precipitated, and then filtered, washed, dried and crushed to obtain LHLC.

Production Methods of Bulk Levamisole Hcl Powder.

Racemic tetraimidazole as raw material, obtained by splitting, alkali precipitation, acidification into salt. Bis-benzoyl-D-tartaric anhydride was boiled in water for 40min, hydrolysed and neutralised with sodium hydroxide solution to PH7.5, and added with racemic tetraimidazole. Levamisole and bis-benzoyl tartaric acid to form a salt and precipitated.

After separation, sodium hydroxide solution is added to PH=9 and levamisole is decomposed. Then dissolved in dilute hydrochloric acid solution, after decolourisation by activated carbon, the filtrate was concentrated nearly dry, and crystals were precipitated by adding acetone and cooling to 0℃. Filtered and dried to obtain levamisole hydrochloride.