• Human APIs PowderRespiratory Drugs Raw Material Antiviral Antibacterial Antipyretic Analgesics Antihistamine Drugs Antineoplastic Cosmetic Raw Material
  • Pharmaceutical IntermediatesPharmaceutical intermediates Nutritional Supplements Pharmaceutical raw materials
  • OEM & ODMCapsule Softgel Capsule Gummies Drop & drinks Tables
  • Veterinary raw materialsAntibacterial anti-inflammatory Respiratory Drugs Anthelmintics Antiviral drugs Feed additives
  • About UsCompany profileQualificationQuality AssuranceService teamFactory TourR&D Center
  • Cefazolin Sodium raw material Cefazolin Sodium Powder 27164-46-1

    • Cefazolin Sodium raw material Cefazolin Sodium Powder 27164-46-1
    • Cefazolin Sodium raw material Cefazolin Sodium Powder 27164-46-1 storehouse
    • Cefazolin Sodium raw material Cefazolin Sodium Powder 27164-46-1 quality testing
    • Cefazolin Sodium raw material Cefazolin Sodium Powder 27164-46-1 quality testing
    • Cefazolin Sodium raw material Cefazolin Sodium Powder 27164-46-1 certificate

    Product Overview:

    Cephalosporins are semi-synthetic antibiotics containing cephalosporin in the molecule. Once translated as vanguardin. They belong to the β-lactam group of antibiotics and are derivatives of 7-aminocephalosporanic acid (7-ACA) of the β-lactam antibiotics, so they have similar bactericidal mechanisms. This class of drugs destroys the cell wall of bacteria and sterilises them during the reproductive phase. It has a strong selective effect on bacteria, while almost no toxicity to human beings, with the advantages of wide antibacterial spectrum, strong antibacterial effect, resistance to penicillinase, and allergic reactions less common than penicillin class. So it is an important antibiotic with high efficiency, low toxicity and widely used in clinic.

    Cefazolin Sodium raw material Cefazolin Sodium Powder 27164-46-1 Attributes

    Cefazolin Sodium raw material Cefazolin Sodium Powder 27164-46-1

    CAS:27164-46-1

    MF:C49H81NO23

    Cefazolin Sodium

    MW:1052.16

    EINECS:616-119-1

    Specification: 99% min Cefazolin Sodium Powder

    Sample:Cefazolin Sodium Powder

    Packaging:1kg/bag, 25kg/drum

    Brand: Henrikang

    Appearance: White Powder

    Storage: Cool Dry Place

    Shelf Life: 2 Years

    Test Method: HPLC

    Cefazolin Sodium raw material Cefazolin Sodium Powder 27164-46-1 Details

    Cefazolin Sodium Powder Usage and Synthesis.

    The first generation of cephalosporins was developed earlier, with stronger antibacterial activity, narrower antibacterial spectrum, and better anti-Gram-positive than Gram-negative bacteria. It is stable against β-lactamase produced by Aureobacteria and unstable against β-lactamase produced by negative bacilli, and can still be destroyed by β-lactamase produced by many Gram-negative bacilli.

    Cefazolin sodium is a semi-synthetic 1st generation cephalosporin, it has antibacterial effect on both gram-positive and gram-negative bacteria, and is commonly used in respiratory system, genitourinary system, skin and soft tissues, bones and joints, biliary tract and other infections caused by sensitive bacteria, and can also be used in endocarditis, septicaemia, pharyngeal and ear infections it has strong activity against gram-positive bacteria such as Aureus, Streptococcus (except enterococci), and it is better than the second and third generation cephalosporins, It has strong activity against gram-positive bacteria such as Aureus, Streptococcus (except enterococci), which is better than the second and third generation cephalosporins.

    Cefazolin Sodium Powder

    Uses and functions of Cefazolin Sodium.

    Cefazolin Sodium is used for the treatment of respiratory tract infections such as otitis media, bronchitis, pneumonia, urinary tract infections, soft tissue skin infections, bone and joint infections, sepsis, infective endocarditis, infections of the hepatic and biliary system, and infections of the eye, ear, nose, and throat due to sensitive bacteria.

    Cefazolin Sodium can also be used as a prophylactic agent before surgery.Cefazolin Sodium should not be used for central nervous system infections. Cefazolin Sodium is not suitable for the treatment of gonorrhoea and syphilis.

    Cefazolin Sodium

    Pharmacological Effect of Cefazolin Sodium.

    It is used for the treatment of respiratory tract infections such as otitis media, bronchitis, pneumonia and other respiratory tract infections caused by sensitive bacteria, urinary tract infections, skin and soft tissue infections, bone and joint infections, septicaemia, infective endocarditis, infections of liver and biliary system, and infections of the eye, ear, nose and throat. This product can also be used as a prophylactic drug before surgery.

    This product should not be used for central nervous system infections. It is less effective in chronic urinary tract infections, especially those accompanied by anatomical abnormalities of the urinary tract.

    It should not be used in the treatment of gonorrhoea and syphilis. Cefazolin sodium is a semi-synthetic 1st generation cephalosporin.

    Its mechanism of action is to bind with penicillin-binding proteins (PBPs) on the bacterial cell membrane (mainly with PBP-1, PBP-3), inhibit the synthesis of the bacterial cell wall, and thus play an antibacterial role.

    The antibacterial characteristics of this product: the stability of β-lactamase produced by Staphylococcus aureus is better than the 2nd and 3rd generation cephalosporins, and the antibacterial effect on Gram-positive bacteria, including penicillin-sensitive and drug-resistant Staphylococcus aureus (except methicillin-resistant Staphylococcus aureus) is stronger than that of the 2nd and 3rd generation cephalosporins; it is unstable against β-lactamase produced by Gram-negative bacilli, and its action on Gram-negative bacilli is stronger than the 1st generation of cephalosporins. It is unstable to β-lactamase produced by Gram-negative bacilli, and its effect on Gram-negative bacilli is the first among the 1st generation cephalosporins, but not as strong as the 2nd and 3rd generation cephalosporins.

    It has good antibacterial effect on Staphylococcus spp (except methicillin-resistant Staphylococcus), Streptococcus pneumoniae, meningococcus, Streptococcus spp, Gonococcus spp. It has antimicrobial effect on Escherichia coli, Streptococcus chrysosporium, anaerobic bacteria, Klebsiella spp. and so on; and it has a certain antimicrobial effect on Haemophilus influenzae (moderately sensitive).

    Pseudomonas aeruginosa, Serratia marcescens, Mimicrobium fragilis, indole-positive Proteus, Enterobacteriaceae, Mycoplasma, Enterococcus, Citrobacter, enzyme-producing gonococcus, Chlamydia, and Fusobacterium indolens are resistant to the product.

    Cefazolin Sodium 27164-46-1

    Drug interactions of Bulk Cefazolin Sodium Powder.

    1. This product is contraindicated with the following drugs, not to be injected in the same bottle: Amikacin Sulfate, Kanamycin Sulfate, Chrysomycin Hydrochloride, Hygromycin Hydrochloride, Tetracycline Hydrochloride, Erythromycin Gluconate, Polymyxin B Sulfate, Mucin Methanesulfonic Acid Sodium, Calcium Gluconate.

    2. This product can enhance the antibacterial effect in vitro when combined with gentamicin or amikacin.

    3. The combination of this product with strong diuretics may increase nephrotoxicity, and the combination with aminoglycoside antibiotics may increase the nephrotoxicity of the latter.

    4. Probenecid can increase the blood concentration of this product and prolong the blood half-life.

    Our advantage
    Our Factory
    Shipping
    Tel: 86-29-89601602
    WhatsApp: 8615091775531
    WeChat: 15091775531
    E-mail: sales21@interlgroup.com
    Add: Fengcheng 2nd Road, Weiyang District, Xi'an, Shaanxi, China
    ©2023 Xi'an Henrikang Biotech Co., Ltd.,