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  • Dexamethasone Acetate Raw Materials Dexamethasone Acetate Powder

    • Dexamethasone Acetate Raw Materials Dexamethasone Acetate Powder
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    • Dexamethasone Acetate Raw Materials Dexamethasone Acetate Powder quality testing
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    Product Overview:

    Dexamethasone acetate is an adrenocorticotropic hormone drug, its anti-inflammatory, anti-allergic, anti-shock effect is more significant than prednisone, while the effect on sodium retention and promotion of potassium excretion is very mild, the pituitary-adrenal inhibition is stronger. It is white or off-white crystal or crystalline powder; odourless, slightly bitter taste. Soluble in acetone, soluble in methanol or anhydrous ethanol, slightly soluble in ethanol or trichloromethane, very slightly soluble in ether, insoluble in water.

    Dexamethasone Acetate Raw Materials Dexamethasone Acetate Powder Attributes

    Dexamethasone Acetate Raw Materials Dexamethasone Acetate Powder

    CAS:1177-87-3

    MF:C24H31FO6

    Dexamethasone Acetate

    MW:434.5

    EINECS:214-646-8

    Specification: 99% min Dexamethasone Acetate Powder

    Sample:Dexamethasone Acetate Powder

    Packaging:1kg/bag, 25kg/drum

    Brand: Henrikang

    Appearance: White to Off-White

    Storage: Cool Dry Place

    Shelf Life: 2 Years

    Test Method: HPLC

    Dexamethasone Acetate Raw Materials Dexamethasone Acetate Powder Details

    Dexamethasone Acetate Powder Usage and Synthesis.

    Dexamethasone acetate is one of the more common drugs, mainly for the white tablets, or white crystalline powder, etc., the taste is a little bitter, belongs to the human body on the kidneys of the corticosteroid drugs, can effectively play a role in anti-inflammatory and reduce the efficacy of the body's inflammation, but also inhibit inflammatory cells in the body, you can treat some of the body's inflammation, but also reduces the efficacy of immunoglobulin.

    Dexamethasone Acetate Powder

    Uses and functions of Dexamethasone Acetate.

    Dexamethasone and its series of products are long-acting adrenocorticotropic hormone drugs, which are widely used in clinic.

    Among them, dexamethasone acetate belongs to corticosteroid drugs, dexamethasone acetate and dexamethasone acetate are mainly used for collagenous diseases, such as rheumatoid arthritis, lupus erythematosus, rheumatic heart disease, rheumatic fever, dermatomyositis, etc. Its anti-inflammatory, anti-allergic and anti-shock effects are more significant than that of prednisone, and its effects on sodium retention and promotion of potassium excretion are very mild, and it is considered to be the strongest of steroids in terms of its inhibitory effects on the pituitary-adrenal gland. Corticosteroids are considered to be one of the most effective drugs with the least side effects.

    Dexamethasone Acetate

    Preparation of Dexamethasone Acetate.

    Add 10g of the reaction material dexamethasone to 30g of dimethyl sulfoxide reaction solvent, add 10g of sodium carbonate to adjust the reaction solvent pH 7 while stirring, reduce the temperature of the reaction solvent to 0 ℃, slowly add 10g of acetic anhydride drop by drop, and react for 2-3h under the condition of less than 15 ℃, no raw material point is detected by TLC, and the reaction is completed, and dexamethasone acetate is added to the water dialysis barrel, and the process control Temperature below 10 ℃, reduce the content of dexamethasone acetate in dimethyl sulfoxide, and finally centrifuged dexamethasone acetate separated out, dried to get dexamethasone acetate 10.5 g of crude product, crude purity of 98.5%, yield 105%.

    Dexamethasone Acetate Raw

    Product Method of  Bulk Dexamethasone Acetate Powder.

    Available 16α,17α-epoxypregna-4-ene-3,11,20-trione (i.e. 16α,17α-epoxy-11-keto progesterone) via (3-position, 20-position ketone group) ketonyl reduction, (11-position ketone group) reduction, elimination [dehydration of the 9(11)-position to form a double bond], (epoxy group with methylmagnesium bromide) addition and hydrolysis (formation of 17α-hydroxy, 16β-methyl) hydrolysis (removal of ethylene glycol) to give 17α-hydroxy-16β-methylpregna-4,9(11)-diene-3,20-dione, which is then subjected to dehydrogenation (formation of a double bond) at the (4- and 5-positions), iodination at the (21-position), displacement (iodine via acetyloxy at the 21-position), addition of [the 9(11)-position double bond with hypobromous acid], epoxidation [at the 9(11)-position], and fluorination of the hydrogen at the 9(11)-position. The product was produced after addition.

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