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  • Triptonide materials Triptonide Powder

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    Product Overview:

    Ranunculus lactone is a diterpenoid isolated from Ranunculus, one of the active ingredients of Ranunculus, which is structurally similar to Ranunculus lactone alcohol and has comparable activity, its structural formula is as follows. It is similar in structure to tretinoin and has the following structural formula. Tretinoin has anti-androgenic effects and some effects on immune function.

    Triptonide materials Triptonide Powder Attributes

    Triptonide materials Triptonide Powder

    CAS:38647-11-9

    MF:C20H22O6

    Triptonide

    MW:358.39

    EINECS:/

    Specification: 99% min Triptonide Powder

    Sample:Triptonide Powder

    Packaging:1kg/bag, 25kg/drum

    Brand: Henrikang

    Appearance:White

    Storage: Store at -20°C

    Shelf Life: 2 Years

    Test Method: HPLC

    Triptonide materials Triptonide Powder Details

    Triptonide Powder Usage and Synthesis.

    Lei Gong Teng Lactone is a natural compound extracted from the traditional Chinese medicine Lei Gong Teng, which has made important breakthroughs in the field of male contraceptive research in recent years.

    Studies have shown that oral administration of tretinoin can induce sperm deformity in male animals, causing them to lose their motility and fertilisation ability, so as to achieve contraceptive effect, and the contraceptive effect is close to 100%.

    At the same time, tretinoin is a non-hormonal male contraceptive candidate, with prospects for translational applications.

    Currently, male contraceptive pills based on tretinoin lactone are under development and are expected to reach the market in the near future.

    Triptonide Powder

    Uses of Triptonide.

    Tretinoin lactone is one of the monomer components in tretinoin, which has a variety of pharmacological effects. Studies have shown that tretinoin lactone has immunomodulatory and anti-inflammatory effects, which can reduce the expression of tumour necrosis factor (TNF)-α-induced phosphorylated JNK, decrease the migration of RAFLS, inhibit the TLR4-induced NF-κB/IL-1β immune pathway, inhibit the NF-κB/TNF-α/VCAM-1 inflammatory pathway, and regulate the TGF-β1/α-SMA/ waveform fibrosis pathway, thus playing a therapeutic role in diseases such as rheumatoid arthritis and dilated cardiomyopathy.

    In addition, tretinoin can be used as a contraceptive agent with an EC50 for contraceptive effect of 0.1 mg/kg, which is much lower than its minimum effective dose (MED) of 0.8 mg/kg and lethal dose (LD50) of 300 mg/kg.

    The target of tretinoin is Junction plakoglobin (JUP), and the new mechanism of its contraceptive effect may be to inhibit the expression of JUP, resulting in the disruption of intercellular junctions, thus preventing spermatogenesis. In addition to this, tretinoin lactone has antifertility, antitumour and antibacterial effects, and is widely used in the treatment of many diseases.

    Triptonide

    Pharmacological Effect of Triptonide.

    Tretinoin lactone can reduce the expression of cancer-promoting non-coding RNA in gastric cancer cells, so that its malignant behaviour is significantly inhibited.

    Tretinoin can significantly inhibit the proliferation of hepatocellular carcinoma cells by inhibiting the expression of Gli1 and Gli2 genes, and the inhibitory effect showed obvious dose-dependence. Tretinoin is an effective inhibitor of Gli1 and Gli2 genes, and can be used to prepare drugs for the prevention and treatment of hepatocellular carcinoma.

    At the same time, since tretinoin is an effective inhibitor of Gli1 and Gli2 gene expression, tretinoin can also be used for the preparation of drugs for the treatment of diseases associated with high expression of Gli1 and Gli2 genes.

    Triptonide raw materials

    Preparation Method of Bulk Triptonide Powder.

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