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  • Phlorizin Raw Materials Phlorizin Powder

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    Product Overview:

    Root bark glycoside is the glucoside of root bark, the chemical name is 1-(2-(beta-D-glucopyranosyloxy)-46-dihydroxyphenyl)-3-(4-hydroxyphenyl)-propanone, which belongs to dihydrochalcone substances in flavonoids.
    Root bark glycosides are mainly found in the root bark, stems, young leaves and apple fruits of the apple tree, and also in small amounts in plants of the Asteraceae, Rhododendron, Leguminosae, Crustacea, and Liliaceae families. It has a variety of important biological activities such as lowering blood sugar, improving memory, anti-allergy, anti-cancer, etc. It has potential utilisation value in food, beauty and health care industries.

    Phlorizin Raw Materials Phlorizin Powder Attributes

    Phlorizin Raw Materials Phlorizin Powder

    CAS:60-81-1

    MF:C21H24O10

    Phlorizin

    MW:436.41

    EINECS:200-487-1

    Specification: 99% min Phlorizin

    Sample:Phlorizin Powder

    Packaging:1kg/bag, 25kg/drum

    Brand: Henrikang

    Appearance:Light Yellow to brown

    Storage: Cool Dry Place

    Shelf Life: 2 Years

    Test Method: HPLC

    Phlorizin Raw Materials Phlorizin Powder Details

    Phlorizin Powder Usage and Synthesis.

    Root bark glycoside is the glucoside of root bark, the chemical name is 1-(2-(beta-D-glucopyranosyloxy)-46-dihydroxyphenyl)-3-(4-hydroxyphenyl)-propanone, which belongs to dihydrochalcone substances in flavonoids.

    Root bark glycosides are mainly found in the root bark, stems, young leaves and apple fruits of the apple tree, and also in small amounts in plants of the Asteraceae, Rhododendron, Leguminosae, Crustacea, and Liliaceae families.

    It has a variety of important biological activities such as lowering blood sugar, improving memory, anti-allergy, anti-cancer, etc. It has potential utilisation value in food, beauty and health care industries.

    Phlorizin Powder

    Uses of Phlorizin.

    1. Food

    Root bark glycosides have been approved as food additives. It is a characteristic phenolic substance in apples. Due to the problems of species and origin, the content of genistein varies greatly from apple to apple, so its content can be used as an indicator to distinguish the origin and quality of apple juice.

    Root bark glycosides can promote the absorption and utilisation of genistein (genistein, inhibiting the growth and metastasis of tumour cells), and the development of functional foods enriched with root bark glycosides and genistein has a broad market prospect in cancer prevention and treatment. It is a very sweet natural sweetener and can be used as a sugar substitute food for diabetics with a sweet tooth.

    It is oxidised by polyphenol oxidase to produce a product that can be converted into a bright yellow dye, which is highly water-soluble and can be used in the food processing industry as a substitute for artificial dyes, avoiding the toxic effects brought about by synthetic colours. It has potential application value both as a food additive and functional food development and utilisation.

    2.Medicine

    Because root bark glycosides are easily hydrolysed in the human body to generate rhizopusin, and root bark glycosides have a low absorption rate in the small intestine, so root bark glycosides are often designed with other compounds to become polymers used in the research and development of drugs.

    3.Cosmetics

    The antioxidant activity and anti-aging function of root bark glycosides have been confirmed by modern scientific research. The hydrolysate of root bark glycosides, rhizodendrin, can competitively inhibit tyrosinase activity, interfering with the synthesis of melanin, and its whitening effect is better than many whitening products on the market.

    However, it should be noted that rhizopusin increases the expression of tyrosinase genes by activating the cAMP signalling pathway, which can lead to melanin production.

    Phlorizin

    Extraction method of Phlorizin.

    (1) Crushing of raw materials: dry apple branches or leaves crushed into 10-20 mesh or 20-30 mesh coarse powder;

    (2) extraction: the crushed coarse powder raw materials into a round-bottomed flask, add 70% methanol reflux extraction 3 times, each time to add the amount of liquid 6, 4, 4BV, 1h each time, the combined extract; (three times, respectively, there are tan to brown extract)

    (3) Concentration: the combined extracts according to the total weight of the extract of 0.2% to add antioxidants VC, 60 ℃ distillation under reduced pressure, the recovery of methanol; (the concentrate is a variety of brown turbid liquid)

    (4) impurities: the concentrate has been recycled to no alcohol by weight of 0.5% to add polymeric alumina, with calcium hydroxide pH 7.5, placed in a conical flask, 60 ℃ insulation for 30min, filtration of the clear liquid; (adding polymeric alumina flocculated precipitate generated at the bottom of the bottle)

    (5) extraction: the extract concentrate cooling, with 1 times the amount of ethyl acetate extraction 3 times, get ethyl acetate solution; (solution layering quickly)

    (6) concentration: ethyl acetate extract reflux under reduced pressure, concentrated to 10:1, get the concentrate;

    (7) purification: the concentrate with 40% methanol dissolved, filtration, filtrate placed 24h, filtration of crystals, atmospheric pressure or decompression dry root bark glycosides. (The crude product was decolourised with activated carbon, which was chosen because its decolourisation principle was physical adsorption and would not harm the biological activity of the root bark glycosides.

    The activated carbon was dried in a vacuum drying oven. Then the activated activated carbon is added into the aqueous solution of the crude product, stirred, filtered, and clarified liquid is obtained. It is left to crystallise naturally, and white needle-like crystals appear in the end.

    Phlorizin Raw Powder

    Synthesis Method of Bulk Phlorizin Powder.

    The precursors for the synthesis of root bark glycosides are malonyl-monoacyl-coenzyme A (Malonyl-CoA) and p-coumaroyl-coenzyme A (p-coumaroyl-CoA).

    Firstly, p-coumaroyl-CoA generates 4-hydroxydihydrocinnamoyl-CoA via the NADPH pathway; then, malonyl-CoA and 4-hydrocinnamoyl-CoA generate rhizopodophyllin by the action of chalcone synthetase; and lastly, rhizopodophyllin glucosylates to generate rhizopodoside.

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