capsaicin Raw Materials capsaicin Powder

CAS:404-86-4

MF:C18H27NO3

MW:305.41

EINECS:206-969-8

Specification: 99% min capsaicin

Sample:capsaicin Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance:White

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

capsaicin Powder Usage and Synthesis.

Natural capsaicin (Capsaicinoids) consists of a series of similar substances, has been found to have 19 kinds of analogues, they all have a common part of the structure, the earliest extracted from the chilli pepper by Thresh in 1876, is a hot chilli pepper in the spicy substances.

It has analgesic, anti-cancer, blood lipid regulation, antibacterial and anti-inflammatory, weight loss, anti-fatigue, analgesic, anti-itch, anti-inflammatory, antioxidant, myocardial protection and regulation of blood pressure, etc., and can also lead to vasodilation of the skin, improve microcirculation, and can be used to stimulate the taste of the spicy to produce a series of physiological responses to people and animals and the role of repellency.

Therefore, it has a wide range of applications, mainly in the field of medical treatment, beauty, biological control, food additives, military and other fields.

Uses of capsaicin.

1. Biological control

a. Green grain storage with capsaicin as the main component of rodent repellent for rural grain storage pests have a good repellent effect, containing 1% capsaicin repellent repellent effect can be maintained for more than five months.

b. Protection of cables and optical fibre cable capsaicin irritation of animals will have a repellent effect, for cable, optical fibre cable industry can be used as a rodent-proof cable sheathing plastic additives; used in PVC, PE and other plastics can be prevented from rodents, termites on the product of the eclipse injury

c. Anti-fouling coatings using capsaicin repellent properties made of bio-fouling coatings, coated on ships and offshore buildings in contact with seawater, can effectively prevent the attachment of marine organisms and aquatic organisms in the hull of the gathering.

At present, capsaicin has replaced organotin as a new type of anti-fouling coatings for ships and offshore buildings in the field of anti-fouling.

d. Capsaicin can be used as a new type of green pesticide in the field of biopesticide, with good poisoning, repellent effect, high efficacy in crop pest control, long-lasting and degradable characteristics, is a new type of environmentally friendly biopesticide.

2.Medical beauty

a.Medical capsaicin has significant effect on neuropathic pain, rheumatoid arthritis, psoriasis, psoriasis, acne, baldness and so on. One of the analgesic is currently capsaicin research is the most mature application.

Capsaicin can also be used in the prevention and treatment of cardiovascular and cerebrovascular diseases, in addition, capsaicin can also prevent and control peptic ulcer and respiratory diseases, and has a weight loss, anti-fatigue and assist in the special effects of drug treatment.

b. Beauty can be used as a raw material for the production of beauty care products, for the face, arm skin improvement, but different parts of the concentration of the difference should pay attention to.

Pharmacological Effect of capsaicin.

1. Prevention of cardiovascular disease

If LDL is oxidised, the oxidised LDL generated will block the arteries, leading to atherosclerosis.

Capsaicin is a potential antioxidant. Capsaicin is a potent vasodilator and diuretic in salt-induced hypertension in rats, and maintains normal blood pressure by balancing the neural and hormonal systems. Calcitonin gene-related peptide is a peptide released from capsaicin-sensitive sensory nerve endings, which is associated with cardiovascular diseases, especially hypertension.

2.Prevention and treatment of digestive diseases

Capsaicin-sensitive afferent nerves play an important role in the defence mechanism of gastric mucosa. Capsaicin can stimulate the afferent nerves and increase the release of CGRP and P substances in the stomach and protect the gastric mucosa. Capsaicin-sensitive perceptual nerves play an important role in the defence mechanism of the gastric mucosa by mediating the regulation of gastric functions such as mucosal blood flow and gastric peristalsis, which not only protects the gastric mucosa in case of injury, but also facilitates the healing of the injury.

Capsaicin can stimulate the oral mucosa to increase salivary secretion of amylase, reflexively increase gastric motility, improve the activity of digestive enzymes, and improve digestive function.

3. The effect on respiratory diseases, if people do not wear gas masks exposed to 0.5 ~ 1.0ppm chlorine gas for 15min, it will cause nasal obstruction reaction. Rats also have a similar direct nasal obstruction reaction to humans. Pretreatment with capsaicin can significantly reduce the irritation and nasal obstruction reaction of rats to chlorine gas.

4. Analgesic

Capsaicin's effect on sensory nerves is manifested in the fact that topical application of capsaicin can desensitise the body to stimuli such as pain and itching without affecting the threshold of mechanical stimuli, such as temperature, pressure or tactile stimuli. Capsaicin can be used as a typical analgesic in the treatment of different pain conditions, and can slow down and improve the pain of patients with other methods can not or rarely control.

5. Anti-cancer

Capsaicin can alter the expression of genes associated with tumours. Capsaicin is effective in the treatment of human hepatocellular carcinoma.

Capsaicin has anti-male prostate cancer cells, capsaicin is expected to become a substitute for chemical drugs for the treatment of prostate cancer. 6. weight loss capsaicin can promote lipid metabolism, and can dissolve fat, inhibit the accumulation of fat in the body. Capsaicin has anti-prostate cancer cells in men, capsaicin is expected to become a substitute for chemical drugs for the treatment of prostate cancer.

6. Weight loss

Capsaicin can promote lipid metabolism, and can dissolve fat, inhibit fat accumulation in the body. Capsaicin into the body, can promote the secretion of nerve transmitting substances acetylcholine and norepinephrine, and adrenaline through sweating, fat burning can play a more effective role in weight loss.

Physicochemical property of Bulk capsaicin Powder.

The nature of capsaicin-like substances and capsaicin is very similar to capsaicin, capsaicin pure product was monoclinic rectangular flake or needle colorless crystals, melting point 65 ℃, boiling point 210-220 ℃, soluble in ethanol, ether, acetone, benzene and chloroform and other organic solvents and hot water and dilute alkali solution, slightly soluble in carbon disulfide, insoluble in cold water, capsaicin-like substances are chemically stable in a variety of organic solvents in the process of extraction losses Very small, but at high temperatures will produce irritating vapours. In alkali solution, phthalamide will be hydrolysed into vanillylamine and decenoic acid.

It is easy to crystallise in ether and petroleum ether. Capsaicin is weakly acidic because of its phenol light group, and can be colour-forming reaction with Ferrin reagent. As the nitrogen atom in the molecule of capsaicinoid molecule exists in the form of phthalamide bond, the alkalinity is almost disappeared, and it can't combine with acid to react.

Capsaicin in low concentration often forms purple oil soluble substance with pigment body, ligand body and phospholipid.