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  • Sodium Stearyl Fumarate Raw Materials Sodium Stearyl Fumarate Powder

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    Product Overview:

    Sodium Stearyl Fumarate is obtained by reacting stearyl alcohol with maleic anhydride, isomerizing the reaction product and then forming a salt, i.e. sodium stearyl fumarate. Sodium stearyl fumarate is a hydrophilic lubricant, used as a lubricant in pharmaceutical excipients, it can overcome many of the problems associated with magnesium stearate, such as the main drug is affected by excessive lubrication; the formation of a protective film in effervescent tablets, which improves disintegration and promotes dissolution, thereby increasing bioavailability.

    Sodium Stearyl Fumarate Raw Materials Sodium Stearyl Fumarate Powder Attributes

    Sodium Stearyl Fumarate Raw Materials Sodium Stearyl Fumarate Powder

    CAS:4070-80-8

    MF:C22H41NaO4

    Sodium Stearyl Fumarate

    MW:392.56

    EINECS:223-781-1

    Specification: 99% min Sodium Stearyl Fumarate Powder

    Sample:Sodium Stearyl Fumarate Powder

    Packaging:1kg/bag, 25kg/drum

    Brand: Henrikang

    Appearance:White

    Storage: Cool Dry Place

    Shelf Life: 2 Years

    Test Method: HPLC

    Sodium Stearyl Fumarate Raw Materials Sodium Stearyl Fumarate Powder Details

    Sodium Stearyl Fumarate Powder Usage and Synthesis.

    Sodium stearyl fumarate (C22H39NaO4) is a widely used and important pharmaceutical food excipient. During the metabolism of sodium stearyl fumarate in animals, most of it can be absorbed and hydrolyzed to produce stearyl alcohol and stearic acid, and a small part of it can be metabolized directly and rapidly, which is non-toxic and non-irritating.

    In the pharmaceutical field, sodium stearate fumarate is added to pharmaceutical preparations, which can be used as a lubricant for tablets and capsules, and can also form a protective film in effervescent tablets, which can solve the problems of stearate lubricants, and can improve the disintegration of the drug, and promote the dissolution of the drug.

    In the food field, the FDA permits sodium stearate fumarate as a regulator and stabilizer to be added directly to food products for human consumption, such as various baked foods, flour thickened foods, dried potatoes and processed grains, etc., and the amount of its addition can account for 0.2-1.0% of the weight of the food product.

    Sodium Stearyl Fumarate Powder

    Uses and Function of Sodium Stearyl Fumarate.

    Sodium stearate fumarate: used as a lubricant for tablets and capsules, the common amount is 0.5~2.0%, it is also used in some foods.

    It is a hydrophilic lubricant, soluble in water, but its solubility is significantly affected by the water temperature, and its solubility is very small in water at 25℃, and white float (sodium stearate fumarate) will appear on the surface of the effervescent solution when the dosage is a little large, which affects the appearance of the solution and the taste.

    Sodium stearate fumarate (C22H39NaO4) is a widely used and important pharmaceutical food excipients. During the metabolism of sodium stearyl fumarate in animals, most of it can be absorbed and hydrolyzed to produce stearyl alcohol and stearic acid, and a small portion of it can be metabolized directly and rapidly, with non-irritating properties.

    In the field of pharmaceuticals, sodium stearate fumarate is added to pharmaceutical preparations, can be used as a lubricant for the agent and capsule, but also in the effervescent tablets to form a protective film, which can solve the problems of stearate lubricants, columbium play a role in improving the disintegration of the drug, and to promote the role of drug dissolution.

    Sodium Stearyl Fumarate

    Preparation of Sodium Stearyl Fumarate.

    A preparation method of sodium stearic fumarate excipient, comprising the following steps: S1, mixing maleic anhydride, octadecanol and reaction solvent, and carrying out a ring-opening reaction at a temperature of 80 ℃ and above; S2, adding a transforming agent to the reaction system, and carrying out a transforming reaction; S3, lowering the temperature to 40-50 ℃, dropping sodium-containing alkali solution to the reaction system, and precipitating crystals by lowering the temperature after stirring and reaction end, and obtaining a crude sodium stearic fumarate; S4, refining the crude sodium stearic fumarate, and obtaining a sodium stearic fumarate product

    Product Methods of  Bulk Sodium Stearyl Fumarate Powder.

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