pure D-serine Powder CAS:312-84-5 supplier

CAS: 312-84-5

MF: C3H7NO3

MW: 105.09

EINECS: 206-229-4

Specification: 99% min D-serine Powder

Sample: D-serine Powder Avaliable

Packaging: 1kg/bag, 25kg/drum

Brand: Ausreson

MOQ: 1kg

Appearance: White powder

Storage: Store at -20°C

Shelf Life: 2 Years

Test Method: HPLC

How D-Serine Enhances Brain Connectivity

• Mandatory NMDA Activation: For an NMDA receptor to open, it requires both glutamate and D-Serine (or glycine). In 2026, D-Serine is recognized as the more potent and brain-specific co-agonist, essential for "firing up" the neurons responsible for complex memory formation.

• Neuroplasticity Promotion: By facilitating LTP (Long-Term Potentiation), D-Serine helps "wire" the brain more efficiently. In 2026, it is a staple in protocols for Cognitive Rehabilitation and accelerated learning.

• Psychiatric Adjunct Therapy: Emerging 2026 clinical data highlights D-Serine's role in alleviating the "negative symptoms" of schizophrenia by addressing the NMDA hypofunction hypothesis.

• Mood Regulation: By balancing glutamatergic signaling, D-Serine powder is used in 2026 to enhance the effects of traditional antidepressants and support emotional resilience.

D-serine Powder Usage and Synthesis.

D-serine is an important chiral intermediate widely used in medical research. In recent years, research centered on D-serine has become one of the hotspots in the field of neuroscience, and many important results have been achieved. With the deepening of the applied research on D-serine, the demand for it is also increasing, thus, a cost-effective process for producing D-serine is needed.

Currently, the main methods reported for the preparation of D-serine are microbial transformation or enzymatic disassembly and conventional disassembly.

Uses of D-serine.

D-serine is an important chiral intermediate widely used in medical research. In recent years, research centered on D-serine has become one of the hotspots in the field of neuroscience, and many important results have been achieved. With the deepening of the applied research on D-serine, the demand for it is also increasing, thus, a cost-effective process for producing D-serine is needed.

Currently, the main methods reported for the preparation of D-serine are microbial transformation or enzymatic disassembly and conventional disassembly.

What is D-Serine?

D-Serine is a D-form amino acid, meaning it is a structural mirror-image of the L-form amino acids that make up most of our proteins. It is not derived from dietary protein but is synthesized within the brain, primarily by glial cells.

Its core function is to serve as a co-agonist for the NMDA (N-Methyl-D-Aspartate) receptor. Think of it as a "master key" system:

Glutamate (the primary excitatory neurotransmitter) is the "first key" that inserts into the NMDA receptor lock.

D-Serine is the "second key" that must be turned simultaneously to successfully unlock the receptor.

Once activated, the NMDA receptor is critical for synaptic plasticity (the foundation of learning and memory), neuronal communication, and normal brain function.

Without sufficient D-Serine, NMDA receptors cannot function effectively, potentially impacting cognitive processes.

Potential Health Benefits of D-Serine (Based on Scientific Evidence)

Research suggests that imbalances in D-Serine levels may be linked to various neurological conditions. Supplementation may offer several potential benefits:

Supports Cognitive Function & Memory

By optimizing NMDA receptor function, D-Serine may directly enhance learning, memory formation, and recall. Some studies are exploring its positive role in age-related cognitive decline.

A Novel Approach in Neurological Research

Significant research focuses on D-Serine's application in supporting certain neurological health challenges due to its intimate link to NMDA receptor function. This research is still in early stages but shows future potential.

May Support Mood Health

NMDA receptors are also involved in mood regulation. Preliminary studies suggest D-Serine may offer supportive benefits for emotional well-being by modulating this pathway, though more clinical evidence is needed.

What foods are high in D-serine?

Serine is found in soybeans, nuts (especially peanuts, almonds, and walnuts), eggs, chickpeas, lentils, meat, and fish (especially shellfish). Serine is produced by the body when insufficient amounts are ingested.

Does L-serine cause weight gain?

(b) L-serine significantly reduces ingestion and weight gain by reducing the expression of foodborne peptides. (c) L-serine addition reduces blood sugar and improves blood glucose tolerance, thereby reducing the incidence of type 1 diabetes in Non-obese diabetes (NOD) mice

How to Take D-Serine: A Dosage Guide

There is no universal "one-size-fits-all" dosage due to limited research.

Common Research Dosage Range: Most studies use doses ranging from 30 mg/kg to 60 mg/kg of body weight per day (for a 70 kg / 154 lbs adult, this is approximately 2100 mg to 4200 mg daily).

Beginner Suggestion: A more conservative approach for new users is to start at a much lower dose (e.g., 500-1000 mg daily), assess tolerance, and gradually increase if needed.

Best Time to Take: It can be taken with or without food, although taking it with a meal may help minimize potential stomach upset.

How to Choose a High-Quality D-Serine Supplement

Purity & Ingredients: Look for products stating high purity (e.g., 99%) and avoid unnecessary fillers, additives, and artificial ingredients.

3rd Party Testing: Prioritize supplements that are tested by an independent third-party lab to verify ingredient accuracy and ensure they are free from heavy metals and contaminants.

Brand Reputation: Choose transparent brands with a strong reputation that provide detailed customer service and product information.

Formulation: Some products combine D-Serine with other nootropic ingredients (like Alpha-GPC, Lion's Mane Mushroom) for a synergistic effect. Choose a single-ingredient or complex formula based on your goals.

Frequently Asked Questions

In 2026, we clarify: No. While L-Serine is used for general protein synthesis and lung/metabolic health, D-Serine is a specialized neuro-transmitter modulator specifically for the brain's NMDA receptors.

Yes. 2026 research indicates that D-Serine can enhance Working Memory and Executive Function in healthy individuals, particularly those experiencing age-related cognitive "fog."

In 2026, we emphasize Dosage Precision. While very high doses in animal studies showed renal stress, human clinical doses (typically 30mg/kg) are generally well-tolerated. Always consult a 2026 medical professional for long-term use.

For cognitive enhancement, dosages typically range from 500mg to 2,000mg daily, often split into two doses to maintain steady plasma levels.

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