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Tetraacetylribofuranose Raw Materials CAS:13035-61-5
Product Overview:
Tetraacetyl ribose (1,2,3,5-tetra-O-acetyl-D-ribofuranose), also known as 1,2,3,5-O-tetraacetyl-β-D-furanose, has a molecular formula of C13H18O9. It is generally produced by degradation and acylation of nucleotides. Its main industrial production method is to obtain the product by acetylation, cracking and crystallization of nucleosides. In the above process, two isomers are mainly produced: 1,2,3,5-tetra-O-acetyl-β-D-furanose (referred to as β-tetraacetyl ribose) and 1,2,3,5-tetra-O-acetyl-α-D-furanose (referred to as α-tetraacetyl ribose).
Tetraacetylribofuranose Raw Materials CAS:13035-61-5 Attributes
CAS:13035-61-5
MF:C13H18O9
MW:318.28
EINECS:235-898-5
Specification: 99% min Tetraacetylribofuranose powder
Sample:Tetraacetylribofuranose powder
Packaging:1kg/bag, 25kg/drum
Brand: Raw Materials
Appearance:White
Storage: Cool Dry Place
Shelf Life: 2 Years
Test Method: HPLC
Tetraacetylribofuranose Raw Materials CAS:13035-61-5 Details
Tetraacetylribofuranose Powder Usage and Synthesis.
Tetraacetyl ribose is an important intermediate in the production of the antiviral drug triazole riboside in the pharmaceutical industry. It is mainly used to synthesize the broad-spectrum antiviral drug ribavirin and is also the starting material for the synthesis of nucleoside compounds.
Uses of Tetraacetylribofuranose.
Tetraacetyl ribose is a chemical substance with a variety of possible uses. First, according to the information on Tuoxin Pharmaceutical's investor interaction platform, one of the company's products, tetraacetyl ribose and nicotinamide riboside (NR), can be used in the downstream production of NMN.
In addition, Chengyi Pharmaceutical has also obtained an invention patent related to tetraacetyl ribose, which is about how to utilize the waste tetraacetyl ribose in the residual liquid of ribose crystals.
This shows that tetraacetyl ribose is not only an intermediate, but also a means of resource utilization of waste. However, the information provided in the third paragraph does not clearly state the specific use of tetraacetyl ribose, but only mentions its chemical name and some synonyms.
Therefore, we can conclude that tetraacetyl ribose has important application value at least in the fields of medicine and chemistry, and is being studied and developed for a wider range of applications.
Preparation of Tetraacetylribofuranose.
Take a 1000mL flask, add 50g inosine and 200ml acetic anhydride, stir and heat to reflux, the internal liquid temperature is 120℃, clarify in about 60 minutes, cool to 100℃, add 10g catalyst (NaSiO3 and Na2HPO4 mixed at 2:1), keep warm at 110℃ for 2h, connect to Vickers fractionation column, evaporate the mixture of acetic acid and acetic anhydride under slight negative pressure, evaporate 100ml of acid, about 100min. Continue to keep warm at 110℃ for 6h, track the end point with thin layer chromatography plate until triacetyl inosine basically disappears.
Cool to 30℃, filter, combine the filtrate, vacuum evaporate the mixed acetic anhydride on a rotary evaporator, cool the residue to 90-100℃, add distilled water, 150ml, crystallize under stirring, and precipitate tetraacetyl ribose, the yield of this ribose is 94.8%.
Product Method of Bulk Tetraacetylribofuranose Powder.
