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  • Sinomenine Hydrochloride raw Powder CAS 11138-66-2 Sinomenine Hydrochloride

    • Sinomenine Hydrochloride raw Powder CAS 11138-66-2 Sinomenine Hydrochloride
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    • Sinomenine Hydrochloride raw Powder CAS 11138-66-2 Sinomenine Hydrochloride quality testing
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    Product Overview:

    Cymbidium hydrochloride enteric-coated tablets is a prescription drug whose main ingredient is cymbidium hydrochloride, which is suitable for the treatment of acute arthritis and rheumatoid arthritis

    Sinomenine Hydrochloride raw Powder CAS 11138-66-2 Sinomenine Hydrochloride Attributes

    Sinomenine Hydrochloride Raw Powder Maltitol

    CAS:6080-33-7

    MF:C19H24ClNO4

    Sinomenine Hydrochloride

    MW:365.85

    EINECS:618-347-7

    Specification​: 99% min Sinomenine Hydrochloride

    Sample:Sinomenine Hydrochloride Powder

    Packaging:1kg/bag, 25kg/drum

    Brand: Raw Materials

    Appearance:white

    Storage: Cool Dry Place

    Shelf Life: 2 Years

    Test Method: HPLC

    Sinomenine Hydrochloride raw Powder CAS 11138-66-2 Sinomenine Hydrochloride Details

    Sinomenine Hydrochloride Usage and Synthesis.

    Analgesia: It has obvious analgesic effects on a variety of pain models, including electric stimulation, hot plate method, photothermal stimulation and acetic acid twisting method caused by the pain response in mice. Its pathways of action include analgesic effects on the centre and inhibition of prostaglandin synthesis and release. 

    Anti-inflammatory: It can significantly reduce the increase of vascular permeability induced by 5-HT, and has obvious inhibitory effect on the swelling of the toe of rats induced by carthamus tinctorius. It has obvious improvement effect on rat adjuvant arthritis model and can significantly reduce the systemic lesions in rats. 

    Immunomodulation: It has significant inhibitory effect on the synthesis of cytokines IL-1, IL-2, IL-6 and TNF by human peripheral blood mononuclear cells, significantly reduces phagocytosis rate of mouse macrophages, and significantly inhibits the synthesis of inflammatory mediators PGE2, LTC4 and Nitrogen oxides. It has anti-T-lymphocyte proliferation and synovial membrane proliferation effects, and can inhibit the body's immune rejection reaction. 

    Sedation: it can significantly reduce the spontaneous activity of mice, and has no significant effect on the sleep time of barbiturates, and has an antagonistic effect on strychnine, but cannot oppose pentamethylene tetrazolium. Dogs and monkeys orally administered with 45-95mg/kg of the drug also have obvious sedative effects, and can eliminate the ‘irritation’ reaction induced by electrical stimulation in mice. 

    Sinomenine Hydrochloride powder

    Uses of Sinomenine Hydrochloride.

    Sedation: It can significantly reduce the spontaneous activity of mice, and has no obvious effect on the sleep time of barbiturates; it has antagonistic effect on strychnine, but cannot oppose pentamethylene tetrazolium. Dogs and monkeys orally administered with 45-95mg/kg of the drug also have obvious sedative effects, and can eliminate the ‘irritation’ reaction caused by electrical stimulation in mice. 

    Cough suppressant: In mice (SO2 method) and cats (electrical stimulation of the superior laryngeal nerve method), its cough suppressant effect is similar to that of codeine. 

    Antihypertensive: Injecting 0.27mg/kg of this product into dogs, it has obvious acute antihypertensive effect, and the second injection can produce rapid tolerance. 

    Sinomenine Hydrochloride

    Preparation of Sinomenine Hydrochloride.

    Product Method of Sinomenine Hydrochloride.

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