WeChat: 18419147460
Phone: 86-18419147460
E-mail: sales03@nutritionoem.com
Add: Fengcheng 2nd Road, Weiyang District, Xi'an, Shaanxi, China

wholesale Sinomenine Hydrochloride hcl Powder | Ausreson

< >

Product Overview:

Cymbidium hydrochloride enteric-coated tablets is a prescription drug whose main ingredient is cymbidium hydrochloride, which is suitable for the treatment of acute arthritis and rheumatoid arthritis

Product Attributes

Sinomenine Hydrochloride Raw Powder Maltitol

CAS:6080-33-7

MF:C19H24ClNO4

MW:365.85

EINECS:618-347-7

Specification: 99% min Sinomenine Hydrochloride

Sample:Sinomenine Hydrochloride Powder Avaliable

Packaging:1kg/bag, 25kg/drum

Brand: Ausreson

MOQ:1 kg

Appearance:white powder

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Product Details

Last updated: March 2026

Click here to order now!

Sinomenine Hydrochloride Usage and Synthesis.

Analgesia: It has obvious analgesic effects on a variety of pain models, including electric stimulation, hot plate method, photothermal stimulation and acetic acid twisting method caused by the pain response in mice. Its pathways of action include analgesic effects on the centre and inhibition of prostaglandin synthesis and release.
Anti-inflammatory: It can significantly reduce the increase of vascular permeability induced by 5-HT, and has obvious inhibitory effect on the swelling of the toe of rats induced by carthamus tinctorius. It has obvious improvement effect on rat adjuvant arthritis model and can significantly reduce the systemic lesions in rats.
Immunomodulation: It has significant inhibitory effect on the synthesis of cytokines IL-1, IL-2, IL-6 and TNF by human peripheral blood mononuclear cells, significantly reduces phagocytosis rate of mouse macrophages, and significantly inhibits the synthesis of inflammatory mediators PGE2, LTC4 and Nitrogen oxides. It has anti-T-lymphocyte proliferation and synovial membrane proliferation effects, and can inhibit the body's immune rejection reaction.
Sedation: it can significantly reduce the spontaneous activity of mice, and has no significant effect on the sleep time of barbiturates, and has an antagonistic effect on strychnine, but cannot oppose pentamethylene tetrazolium. Dogs and monkeys orally administered with 45-95mg/kg of the drug also have obvious sedative effects, and can eliminate the ‘irritation’ reaction induced by electrical stimulation in mice.

How Sinomenine HCl Calms the Cytokine Storm

Inhibition of NF-$\kappa$B Signaling: Sinomenine HCl effectively blocks the activation of the NF-$\kappa$B pathway, the "master switch" for inflammation. In 2026, it is used to reduce the production of pro-inflammatory cytokines like TNF-$\alpha$ and IL-6.
Prostaglandin $E_2$ ($PGE_2$) Suppression: By inhibiting COX-2 activity, it targets the root cause of joint swelling and morning stiffness in RA patients.
Bi-Phasic Immunomodulation: At specific concentrations, it suppresses T-cell proliferation and B-cell antibody production, helping to "reset" the immune system in autoimmune conditions.
Nociceptive Protection: 2026 research highlights its ability to modulate sodium and calcium channels in sensory neurons, providing a natural bridge for managing Neuropathic Pain and Allodynia.

Key Benefits of Sinomenine Hydrochloride

Core Benefits	Mechanism of Action and Explanation	Applicable people
1. Anti-Inflammation and Analgesia	This is more than just a simple painkiller. It reduces inflammation at its source by inhibiting the production of key inflammatory factors (such as TNF-α, IL-1β, and IL-6), thereby alleviating the pain, swelling, and stiffness caused by inflammation.	It is suitable for patients with autoimmune arthritis, such as rheumatoid arthritis and osteoarthritis. They need a medication that controls the root cause (inflammation), not just a temporary pain mask.
2. Immunosuppression	This is one of its most unique and important effects. It inhibits the overactivation of T and B lymphocytes, the main force in the immune system's attack on self-tissues. This effectively cools down an overactive immune system.	It is targeted at patients with autoimmune diseases (such as rheumatoid arthritis). Their core pain point is immune system dysfunction, and they need a medication that helps regulate immune balance, not just anti-inflammatory treatment.
3. Anti-fibrosis	Studies have shown that sinomenine can inhibit fibroblast proliferation and excessive collagen deposition, which theoretically holds promise for the treatment of organ fibrosis (such as pulmonary and liver fibrosis).	This benefit is still under investigation, but offers hope for the future for patients.
4. Kidney Protection	In animal models of diabetic nephropathy, it has demonstrated the potential to mitigate renal damage through anti-inflammatory and anti-fibrotic effects.	This is also a cutting-edge research area, demonstrating its multifaceted potential.

Why "98% Pharmaceutical-Grade Crystalline" is the 2026 Quality Standard

Enhanced Water Solubility: As a hydrochloride salt, Sinomenine HCl is significantly more soluble than the base alkaloid. In 2026, this ensures rapid systemic absorption and higher bioavailability in oral and topical formulations.
Ultra-Low Toxicity Profile: 2026's top-tier 98% Pure Powder undergoes rigorous purification to remove plant resins and heavy metals, minimizing the risk of the "Herxheimer-like" skin reactions sometimes seen with crude extracts.
Stability in Complex Matrices: The HCl form provides a stable pH environment, making it the perfect active ingredient for Transdermal Patches, Anti-Inflammatory Gels, and Precision Capsules.

Frequently Asked Questions

1. Is Sinomenine HCl a steroid?

No. In 2026, we classify it as a Natural Alkaloid with Immunosuppressive properties. It provides anti-inflammatory effects similar to steroids but through different molecular pathways, often with fewer long-term side effects on bone density or metabolism.

2. Can it cause skin itching?

Because Sinomenine can trigger a controlled release of histamine, some users may experience temporary redness or itching. In 2026, we recommend a "Low-and-Slow" dosing strategy to desensitize the mast cells.

3. How does it help with Rheumatoid Arthritis (RA)?

Clinical data in 2026 shows that Sinomenine HCl reduces joint destruction by inhibiting Matrix Metalloproteinases (MMPs) and promoting the apoptosis of inflammatory fibroblast-like synoviocytes.

4. What is the standard 2026 dosage?

For B2B applications, oral doses typically range from 20mg to 60mg per serving, while topical concentrations are standardized at 1% to 5% for localized pain relief.

Hot sale Product
celeroxib	d-chiro-inositol powder	mangosteen extract powder
zinc glycinate powder	guanidinoacetic acid powder	myo-inositol gummies
pure gaa supplement	icariin powder extract	china synephrine powder manufacturers
baclofen powder	honokiol supplement	phytomenadion
vyxion liquid drops	cetilistat api	l-carnitine base powder
We offer OEM services, please contact us for more information>>

Our advantage

We possess extensive experience, handling every step from sourcing each ingredient in the formulation to post-filling inspection, all at the most competitive prices and with the fastest delivery times.

InterlGroup owns factory, Main Product Foods additives, Nutritional supplements, Healthcare Products(capsules,Softgels,tablets,Gummies,Liquid Drops,Gum,solid beverage and other customized products), plant extracts.

Support OEM&ODM service，Design label packaging, Overseas in stock, Fast customization, Drop Shipping.

Intergroup is supplying OEM service for the Well-known brands Reson and Ausreson.

Alibaba International Station No.1 supplier, Alibaba International Station Number 1, Alibaba International Station Number one.

Оптовая продажа порошка синоменина гидрохлорида HCl | Ausreson
Vente en gros de poudre de chlorhydrate de sinoménine HCl | Ausreson
Großhandel mit Sinomenin-Hydrochlorid-HCl-Pulver | Ausreson
Venta al por mayor de polvo de clorhidrato de sinomenina HCl | Ausreson
Venda por atacado de pó de cloridrato de sinomenina HCl | Ausreson