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  • HRK Supply Betulinic Acid raw Powder Betulinic Acid

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    Product Overview:

    Betulinic acid is a pentacyclic triterpenoid compound, which is widely found in the natural world. It was first isolated from the bark of rhamnus evergreen plants growing in East Africa, but the main source was extracted and purified from the bark of betulin. In recent years, scientific research has found that BA is a very valuable natural product. BA and its derivatives, as biologics, have shown great potential in anti-cancer and HIV treatment, and play an important role in the process of anti-oxidative damage and immune regulation of the body. As a promising drug lead compound, BA and its derivatives are of great value for the research and development of new drugs, and the American Cancer Institute NCI has included it in the Rapid research and development planning project (RAID).

    HRK Supply Betulinic Acid raw Powder Betulinic Acid Attributes

    Betulinic Acid Raw Materials Powder

    CAS:472-15-1

    MF:C30H48O3

    Betulinic Acid

    MW:456.71

    EINECS:207-448-8

    Specification: 99% min Betulinic Acid Powder

    Sample:Betulinic Acid Powder

    Packaging:1kg/bag, 25kg/drum

    Brand: Henrikang

    Appearance:white

    Storage: Cool Dry Place

    Shelf Life: 2 Years

    Test Method: HPLC

    HRK Supply Betulinic Acid raw Powder Betulinic Acid Details

    Betulinic Acid powder Usage and Synthesis.

    Antitumor effect: ‌ betulinic acid has selective cytotoxicity to many specific tumor cells. ‌ can inhibit topoisomerase I, ‌ to prevent DNA replication and repair, ‌ to inhibit the growth of tumor cells. In addition, ‌ derivatives of ‌ betulinic acid, while maintaining their structural integrity and function, ‌ have better water solubility, ‌ are more cytotoxic to specific kinds of tumor cells, and ‌ improve the effectiveness of in vivo drug testing. ‌

    Antidiabetic effect: ‌ betulinic acid can inhibit α-amylase and α-glucosidase, ‌ reduce the hydrolysis of polysaccharide and promote the synthesis of glycogen, ‌ thus help control blood glucose level, ‌ has shown good anti-diabetic effect. ‌

    Antioxidative stress: ‌ betulinic acid has a protective effect on normal cells and organism, ‌ has a protective effect on ischemia-reperfusion injury through anti-oxidative stress, ‌, anti-nitridation stress and increased blood flow, ‌ has a protective effect on ischemia-reperfusion injury of brain, ‌ kidney and heart, etc

    Betulinic Acid Powder

    Uses of Betulinic Acid.

    1. Anti-inflammatory effects Most pentacyclic triterpenoids have anti-inflammatory activities. The anti-inflammatory effects of betulinic acid have been demonstrated in vitro and in vivo model systems. It can inhibit PGE2 production and reduce inflammation.

    2. Bacteriostasis has a certain bacteriostasis effect, which can inhibit a variety of bacteria including E. coli, subtilis, Staphylococcus aureus and Staphylococcus epidermidis.

    3. Antiviral effect has a relatively prominent antiviral activity, especially anti-HIV activity, and has an effective effect in the anti-HCV, anti-spora simplex virus, anti-echovirus, anti-influenza virus and other aspects.

    4. Anti-hyperlipidemia effect Studies have found that betulinic acid and its derivatives can play an anti-hyperlipidemia role by regulating adipokine, reducing lipid production, reducing triglyceride and total cholesterol levels and other mechanisms.

    5. Anti-diabetic effect shows good efficacy in the treatment of diabetes, which is mainly treated by inhibiting α-amylase and α-glucosidase, thereby reducing polysaccharide hydrolysis and promoting glycogen synthesis.

    6. Anti-oxidative stress activity BA has a protective effect on normal cells and the body, which has a certain relationship with anti-oxidative stress. For example, betulinic acid has a protective effect on ischemia-reperfusion injury of brain, kidney and heart. BA has protective effect on ischemia-reperfusion brain injury in mice by anti-oxidative stress, anti-nitriding stress and increasing blood flow.

    7. Other diseases There are also some studies that have found that it has a certain improvement in Alzheimer's disease. Its protective effect is mainly through weakening neurobehavioral and cognitive dysfunction, reducing pro-inflammatory cytokines in the hippocampus, and reducing oxidation and nitrosation reactions. At the same time, there are also reports that betulinic acid has a certain anti-anxiety effect, and some anti-anxiety drugs have been used in its components.

    Betulinic Acid

    Drug interaction of Bulk Betulinic Acid powder.

    Product Methods of Betulinic Acid.

    First, it is extracted and separated from natural plants. This method consumes a lot of solvent, low yield, impurities are not easy to separate, so it is rarely used;

    Second, betulinic acid was synthesized by organic synthesis with betulin alcohol as precursor. This method has been applied to industrial production, can obtain industrial scale betulinic acid, is now the main source of betulinic acid in the market;

    Third, betulin acid was produced by microbial transformation using betulin alcohol as a precursor. This approach represents a new direction for the future plant extraction industry, but there are still many technical problems that cannot be solved.

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