• Human APIs PowderRespiratory Drugs Raw Material Antiviral Antibacterial Antipyretic Analgesics Antihistamine Drugs Antineoplastic Cosmetic Raw Material
  • Pharmaceutical IntermediatesPharmaceutical intermediates Nutritional Supplements Pharmaceutical raw materials
  • OEM & ODMCapsule Softgel Capsule Gummies Drop & drinks Tables
  • Veterinary raw materialsAntibacterial anti-inflammatory Respiratory Drugs Anthelmintics Antiviral drugs Feed additives
  • About UsCompany profileQualificationQuality AssuranceService teamFactory TourR&D Center
  • Chloramphenicol Raw material powder Chloramphenicol

    • Chloramphenicol Raw material powder Chloramphenicol
    • Chloramphenicol Raw material powder Chloramphenicol storehouse
    • Chloramphenicol Raw material powder Chloramphenicol quality testing
    • Chloramphenicol Raw material powder Chloramphenicol quality testing
    • Chloramphenicol Raw material powder Chloramphenicol certificate

    Product Overview:

    chloramphenicol is an antibiotic with the chemical formula C11H12Cl2N2O5, soluble in methanol, ethanol, propanol and ethyl acetate, slightly soluble in ether and chloroform, insoluble in petroleum ether and benzene. Chloramphenicol is extremely stable and its aqueous solution does not fail even after boiling for 5h. Because chloramphenicol has two asymmetric carbon atoms in the molecule, chloramphenicol has four optical isomers, of which only the left-handed isomer has antibacterial properties

    Chloramphenicol Raw material powder Chloramphenicol Attributes

    Chloramphenicol Raw material powder

    CAS:56-75-7

    MF:C11H12Cl2N2O5

    Chloramphenicol

    MW:323.13

    EINECS:200-287-4

    Specification: 99% min Chloramphenicol powder

    Sample:Chloramphenicol powder

    Packaging:1kg/bag, 25kg/drum

    Brand: Henrikang

    Appearance:white

    Storage: Cool Dry Place

    Shelf Life: 2 Years

    Test Method: HPLC

    Chloramphenicol Raw material powder Chloramphenicol Details

    Chloramphenicol Powder Usage and Synthesis.

    Chloramphenicol works by inhibiting bacterial protein synthesis. It reversibly binds to the 50S subunit on the bacterial 70S ribosome, thereby preventing the amino acid terminus of the aminoacyl tRNA from binding to receptors on the ribosome. Thus, the amino acid substrate cannot interact with the transpeptidase and therefore cannot form peptide bonds (see Pratt and Fekety, 1986). Chloramphenicol is usually a bacteriosuppressant, but it can be bactericidal in therapeutic concentrations against common meningococcal pathogens such as influenzae, meningococci, and diplococcus pneumoniae (Rahal and Simberkoff, 1979).

    The 70S ribosomes in mammalian mitochondria showed similar physicochemical properties to those in bacterial cells.

    Many adverse effects of chloramphenicol, including dose-related myelosuppression and grey syndrome, appear to be due to inhibition of host mitochondrial protein synthesis.

    Chloramphenicol is mainly used to treat urinary tract infections, pneumonia, abdominal infection and septicemia caused by sensitive bacteria, as well as external eye drops and ear drops. However, due to its effect on the hematopoietic system, it is no longer the first choice.

    Chloramphenicol powder

    Uses of Chloramphenicol.

    It is a broad spectrum antibacterial antibiotic, which is the first choice for the treatment of typhoid fever and paratyphoid fever, and one of the special drugs for the treatment of anaerobic bacteria infection, and is secondly used for the treatment of various infectious diseases caused by sensitive microorganisms. Due to serious adverse reactions, it is being used less and less. It is used to treat infections caused by typhoid, dysentery, Escherichia coli, influenza, brucella, pneumococcus, etc.

    Chloramphenicol

    Drug interaction of Chloramphenicol.

    Chloramphenicol inhibits liver microsomal enzyme metabolism of phenytoin, metobutamide, chlorsulfopropylurea, and biscoumarin (and possibly other drugs), resulting in a prolonged half-life in vivo and increased serum concentration. Aggravated poisoning resulting in death has also been reported. On the other hand, phenobarbital, phenytoin, and rifampicin (Prober, 1985) reduced serum chloramphenicol concentrations, presumably due to the induction of liver enzymes. Therefore, if drugs that may affect the pharmacokinetics of chloramphenicol are used at the same time, attention should be paid to monitoring the serum chloramphenicol concentration.

    Chloramphenicol can delay the response of iron, folate and vitamin B12 to anemia treatment. It also interferes with the host's recall response to tetanus toxoid. Therefore, the simultaneous application of chloramphenicol and active immune agents may also be avoided.

    Although the antagonistic effect of chloramphenicol on the bactericidal effect of penicillin has been confirmed in vitro and animal experiments, its clinical significance is still unclear. This combination of drugs should only be used if the benefits of such treatment have been demonstrated.

    Chloramphenicol raw

    Product Method of Bulk Chloramphenicol Powder.

    There have been a lot of researches on the production methods of chloramphenicol all over the world, which can be summarized as follows: (1) p-nitroacetophenone method; (2) styrene process; (3) cinnamyl alcohol method; (4) p-nitrocinnamyl alcohol method; (5) p-nitrobenzaldehyde method. Chloramphenicol was obtained from ethylbenzene through nitration, oxidation, bromination, salting, hydrolysis, acetylation, addition, reduction, decomposition, separation and dichloroacetylation in China.

    Our advantage
    Our Factory
    Shipping
    Tel: 86-29-89601602
    WhatsApp: 8615091775531
    WeChat: 15091775531
    E-mail: sales21@interlgroup.com
    Add: Fengcheng 2nd Road, Weiyang District, Xi'an, Shaanxi, China
    ©2023 Xi'an Henrikang Biotech Co., Ltd.,