Hrk supply Baloxavir marboxil Raw materials powder

CAS:1985606-14-1

MF:C22H27ClN2O4S

MW:450.98

EINECS:251-443-3

Specification: 99% min Baloxavir marboxil powder

Sample:Baloxavir marboxil powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance:white

Storage: Store at -20°C

Shelf Life: 2 Years

Test Method: HPLC

Baloxavir marboxil powder of Usage and Synthesis.

Baloxavixate is indicated for patients ≥12 years of age with acute uncomplicated influenza within 48 hours of onset of symptoms. Limitations of use should be noted: influenza viruses vary over time and there are factors such as virus type and subtype, and changes in viral resistance and virulence of the virus once they occur may undermine the clinical efficacy of antiviral drugs, and available information on the sensitivity of locally circulating virus strains to drugs should be considered when deciding whether to take basalovir.

Baloxavixolate is a small molecule precursor drug, its mechanism of action is different from the existing antiviral therapy, it can selectively inhibit CAP-dependent endonuclease, can prevent polymerase function and influenza virus mRNA replication. Existing anti-influenza drugs work by targeting neuraminidase. Compared to these drugs, Barloxavir targets an earlier stage of the viral replication cycle.

Uses of Baloxavir marboxil.

baloxavir marboxil is a selective inhibitor of CAP-dependent endonuclease of influenza virus. The drug has shown therapeutic activity in preclinical models of influenza A and B virus infections, including strains resistant to current antiviral agents.

Baloxavixolate, approved by the FDA in 2018, is a new anti-influenza drug with a novel mechanism of action, which can selectively inhibit CAP-dependent endonucrenase and prevent polymerase function and influenza virus mRNA replication.

Valoxavir was developed by Shionoyi Pharmaceuticals and has signed an agreement with Roche, including Roche subsidiary Genentech, to jointly develop and commercialize valoxavir globally, and Shionoyi/Roche is currently conducting influenza phase 3 clinical trials of valoxavir in China.

Pharmacological action of Baloxavir marboxil.

Product Methods of Bulk Baloxavir marboxil powder.