Tenofovir raw Materials powder with Wholesale price

CAS: 147127-20-6

MF: C9H14N5O4P

MW: 287.21

EINECS: 604-571-2

Specification​:  99% min Tenofovir Powder

Sample: Tenofovir Powder Avaliable

Packaging: 1kg/bag, 25kg/drum

Brand: Ausreson

MOQ: 1 kg

Appearance: white powder

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Last updated: March 2026

Tenofovir Powder Usage and Synthesis.

Tenofovir is almost not absorbed through the gastrointestinal tract, so it is esterified and salted as Tenofovir ester fumarate. Tenofovir ester is water-soluble and can be rapidly absorbed and degraded into the active substance Tenofovir, which is then converted into the active metabolite Tenofovir bisphosphonate. Tenofoveda blood drug peak within 1 to 2 hours after administration. Tenofovir bioavailability increases by about 40% when taken with food. Tenofovir bisphosphonates have an intracellular half-life of about 10h and can be administered once a day. Because the drug is not metabolized by the CYP450 enzyme system, interactions with other drugs caused by this enzyme are highly unlikely. The drug is excreted mainly through the glomerular filtration and active tubule transport system, and about 70% to 80% is excreted in its original form through urine.

• Obligate Chain Termination: Tenofovir is a nucleotide analogue. Once it is incorporated into the viral DNA strand by the Reverse Transcriptase enzyme, it lacks the necessary link for the next building block, effectively "terminating" the viral DNA chain.

• HBV Polymerase Inhibition: Beyond HIV, Tenofovir powder is the primary tool for suppressing Hepatitis B DNA to undetectable levels. In 2026, it is a key component in "Functional Cure" trials when combined with siRNA or therapeutic vaccines.

• High Genetic Barrier to Resistance: One of Tenofovir's greatest 2026 strengths is its resilience; viruses find it exceptionally difficult to develop mutations that can bypass its inhibitory effect compared to older NRTIs.

• Intracellular Longevity: Tenofovir has a long intracellular half-life, which allows for the once-daily dosing or even less frequent dosing seen in modern 2026 PrEP protocols.

Uses of Tenofovir.

Nucleotide analogues reverse transcriptase inhibitors block HIV replication. It is used in combination with other antiretroviral drugs to treat HIV-1 infection. Used in the treatment of AIDS.

Why "99% Pharma-Grade Crystalline" is the 2026 Standard

1. TDF vs. TAF Precision: In 2026, we distinguish between Tenofovir Disoproxil Fumarate (TDF) and Tenofovir Alafenamide (TAF). TAF powder is often preferred for 2026 formulations due to its ability to deliver high active concentrations to target cells with lower systemic exposure, reducing kidney and bone risks.

2. Ultra-Low Impurity Profile: For chronic, lifelong therapy, 2026 standards demand $\geq$ 99.5% purity (HPLC). This ensures that synthesis by-products like adenine or isopropyl residues are minimized to prevent long-term toxicity.

3. Micronization for Fixed-Dose Combinations: High-quality Tenofovir powder is micronized to ensure uniform blending with other APIs like Emtricitabine or Lamivudine, ensuring consistent release in 2026's "Single-Tablet Regimens."

Preparation of Tenofovir.

Diethyl phosphite, paraformaldehyde and triethylamine were dissolved in toluene and reacted under nitrogen to reflux. After the reaction was complete, it was cooled and slowly added p-toluenesulfonyl chloride and triethylamine to obtain p-toluenesulfonyloxymethylphosphonate diethyl. Under the protection of nitrogen, (S) -glycidyl, 5% palladium  carbon, ethanol and sodium hydroxide aqueous solution were mixed and hydrogenated to obtain (R)-1, 2-propylene glycol. (R)-1, 2-propylene glycol carbonate was obtained by adding diethyl carbonate and sodium ethanol-ethanol solution.

It was dissolved in dimethylformamide with adenine, diethyl p-toluenesulfonyl methyl phosphonate and sodium hydroxide to obtain (R)-9- [2- (diethylphosphonyl methoxy) propyl] adenine. Dissolve it in acetonitrile, add bromo-trimethylsilane, detenofovir crude, recrystallized to obtain pure product. Tenofovir was mixed with 1-methyl-2-pyrrolidone and triethylamine to react with chloromethyl propyl carbonate, and then acidified with fumarate to obtain Tenofovir fumarate divaleryl methyl ester.

Frequently Asked Questions (FAQ)

In 2026, we clarify: Tenofovir suppresses HBV DNA to undetectable levels, which prevents liver damage and transmission. While not a "complete cure" on its own, it is the foundational treatment used in all 2026 HBV functional cure research.

Tenofovir is the primary "shield" in Pre-Exposure Prophylaxis. When taken consistently, it creates a concentration in the mucosal tissues that prevents HIV from establishing an infection after exposure.

While older versions (TDF) had known risks, 2026 formulations (especially TAF) have significantly reduced these concerns. Monitoring renal function remains a standard 2026 clinical protocol for anyone on long-term Tenofovir therapy.

To maintain 2026 pharmaceutical integrity, store in a cool, dry place ($20-25°C$), protected from light and moisture in air-tight containers.

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