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  • Sexual dysfunctions Tadalafil Raw material powder

    • Sexual dysfunctions Tadalafil Raw material powder
    • Sexual dysfunctions Tadalafil Raw material powder storehouse
    • Sexual dysfunctions Tadalafil Raw material powder quality testing
    • Sexual dysfunctions Tadalafil Raw material powder quality testing
    • Sexual dysfunctions Tadalafil Raw material powder certificate

    Product Overview:

    Tadalafil has a molecular formula of C22H19N3O4 with a molecular weight of 389.4 and has been widely used to treat erectile dysfunction in men since 2003 under the trade name Cialis.

    Sexual dysfunctions Tadalafil Raw material powder Attributes

    Tadalafil Raw material powder

    CAS:171596-29-5

    MF:C22H19N3O4

    Tadalafil

    MW:389.4

    EINECS:687-782-2

    Specification: 99% min Tadalafil powder

    Sample:Tadalafil powder

    Packaging:1kg/bag, 25kg/drum

    Brand: Henrikang

    Appearance:white

    Storage: Cool Dry Place

    Shelf Life: 2 Years

    Test Method: HPLC

    Sexual dysfunctions Tadalafil Raw material powder Details

    Tadalafil Powder Usage and Synthesis.

    Tadanafil is used to treat erectile dysfunction (ED) and pulmonary hypertension in men. Tadalafil and sildenafil belong to the same selective type 5 phosphodiesterase (PDE5), but its structure is different from that of the latter, and a high-fat diet does not interfere with its absorption. Under sexual stimulation, nitric oxide synthase (NOS) in penile nerve endings and vascular endothelial cells catalyzes substrate L-arginine to synthesize nitric oxide (NO). NO activates guanylate cyclase, which converts guanosine triphosphate into cyclic guanosine phosphate (cGMP), thereby activating cyclic guanosine phosphate dependent protein kinase, resulting in a decrease in the concentration of calcium ions in smooth muscle cells, resulting in relaxation of the smooth muscle of the corpus cavernosum and erection. Phosphodiesterase type 5 (PDE5) degrades cGMP into an inactive product, causing the penis to enter a weak state. By inhibiting PDE5 degradation, Tadanafil leads to cGMP accumulation, which relaxes the smooth muscle of the cavernous body of the penis and leads to penile erection. Since nitrates are NO donors, the combination with tadanafil can significantly increase the level of cGMP and lead to severe hypotension, therefore, clinical contraindication of the two.

    Tadalafil powder

    Uses of Tadalafil.

    Phosphodiesterase 5 inhibitors are used to treat erectile dysfunction in men. The second generation phosphodiesterase 5 inhibitors are used to treat bo dysfunction in men.

    Tadalafil

    Drug interaction of Tadalafil.

    Tadanafil affects PDES by inhibiting PDES. GMP degradation, so when used in combination with nitrocetacrets may cause an extreme drop in blood pressure and increase the risk of syncope. CY3PA4 inducer can reduce the abiotic availability of tadana. Combining with rifampicin, cimetidine, erythromycin, clarithromycin, itraconva, ketoconva, HVI protease inhibitor, etc., may increase the blood concentration of Tadana. Attention should be paid to adjust the dose. So far, there are no reports that the pharmacokinetic parameters of this product are affected by diet and alcohol.

    Product Method of Bulk Tadalafil Powder.

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