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  • Pharmaceutical Bulk Benzydamine Hcl Powder

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    Product Overview:

    Benzydamine Hydrochloride, also known as Anti-inflammatory Spirit or Inflammatory Pain Jing, is chemically known as 1-benzyl-3-[3-(dimethylamino)propoxy]-1H-indazole hydrochloride. It is a non-specific anti-inflammatory drug with anti-inflammatory, antipyretic and analgesic effects. It is effective for pain caused by inflammation.

    Pharmaceutical Bulk Benzydamine Hcl Powder Attributes

    BenzydamineRaw Materials Powder

    CAS:132-69-4

    MF: C19H23N3O.ClH

    MW: 345.87

    EINECS: 205-076-0

    Specification​: 99% min Benzydamine Hcl Powder

    Sample: Benzydamine Hcl Powder

    Packaging:1kg/bag, 25kg/drum

    Brand: Henrikang

    Appearance: White Powder

    Storage: Cool Dry Place

    Shelf Life: 2 Years

    Test Method: HPLC

    Pharmaceutical Bulk Benzydamine Hcl Powder Details

    Benzydamine Hcl Powder Usage and Synthesis.

    Benzydamine Hcl is commonly used in various inflammatory diseases caused by surgery and trauma, as well as arthritis, bronchitis and pharyngitis. Benzydamine can be used in combination with antimicrobials or sulphonamides for better efficacy.

    Benzydamine Hcl is structurally unrelated to corticosteroids. benzydamine's effects can be mediated by the prostaglandin system. The drug may affect thromboxane formation and alter prostaglandin biosynthesis, and the desired dose can be achieved with topical administration.Benzydamine Hcl shows stabilising effects on cell membranes, inhibits degranulation of human neutrophils and inhibits platelet aggregation.Benzydamine Hcl may affect tissue biochemistry related to local mechanisms of inflammation and pain.

    Benzydamine Hcl Powder

    Uses and functions of Bulk Benzydamine Hcl Powder

    Benzydamine Hcl is a non-specific anti-inflammatory drug with anti-inflammatory, antipyretic and analgesic properties. It is effective for pain caused by inflammation. Anti-inflammatory effect is similar to or slightly stronger than the bodyguard. benzydamine Hcl has poppy-like antispasmodic effect. Commonly used in surgery and trauma caused by a variety of inflammation and arthritis, bronchitis, pharyngitis. Can be combined with antibacterial agents or sulfonamides for better efficacy.

    Bulk Benzydamine Hcl

    Pharmacological Effects of Bulk Benzydamine Hcl

    Using o-aminobenzoic acid as raw material, Benzydamine is produced through the chemical reactions of diazotisation, reduction, cyclisation, hydrocarbonation, condensation and salt formation. The specific operation is as follows:

    (1) Diazotization while stirring the o-aminobenzoic acid into a certain amount of water, add concentrated hydrochloric acid, so that the reactants are dissolved, and then add hydrochloric acid to make the crystals precipitate. Cold to below 3 ℃, slowly add sodium nitrite aqueous solution dropwise, the temperature does not exceed 3 ℃, continue to stir, get transparent tea-coloured diazonium salt solution.

    (2) reduction at 10 ℃ below, the diazonium salt solution drops into a saturated solution of sulfur dioxide, after standing, add concentrated hydrochloric acid, stirring crystals precipitated, cooled to below 5 ℃, placed, filtered, drained o-hydrazinyl benzoic acid hydrochloride.

    (3) Cyclization will be reduced as well as water, salt reflux 30 minutes, concentration, while hot with sodium carbonate neutralisation to pH 7, placed, filtered, washed, dried, to get 3-hydroxyindazole.

    (4) hydrocarbonation of the cyclic compounds and anhydrous ethanol, sodium hydroxide heating reflux, cold filtration, filtrate frozen overnight precipitation crystals, filtration, drying, that is, 1-benzyl-3-hydroxyindazole.

    (5) condensation of hydrocarbons, xylene and chopped sodium metal heated reflux, stirring while heating until the sodium metal melted, white gas. Stop heating, the reactants thickened to a paste, drops of dimethylaminochloropropane and toluene mixture, drops continue to reflux after the reaction. Let cool, filter and wash with xylene. Combine the filtrate with the wash solution, extract with dilute hydrochloric acid, add liquid alkali, precipitate the oil layer, dry with anhydrous sodium sulfate. This is the free base of benzydamine, and it is refined to hydrochloride according to the normal method.

    Bulk Benzydamine Hcl Powder

    Production method of Benzydamine Hcl.

    Benzydamine hydrochloride soluble tablets:

    The composition is as follows: 250g of benzydamine hydrochloride, 100g of sodium chloride, 25g of cross-linked sodium carboxymethylcellulose, 40g of leucine, 5g of sodium dodecyl sulphate, and 30ml of aqueous ethanol solution with a concentration of 80%.

    Preparation method: according to the following steps:

    a), according to the above proportion of benzydamine hydrochloride with a concentration of 80% ethanol aqueous solution of soft material, through 20 mesh sieve granulation, at 60 ~ 70 ℃ ventilation drying 1 hour;

    b), pass the above dried granules through a 30-mesh sieve to make a whole granule, and then add sodium chloride, cross-linked sodium carboxymethyl cellulose, sodium dodecyl sulfate and leucine in the above proportion in turn, and mix well;

    c), determine the content of the above mixture, calculate the weight of the tablet, and press the tablet to obtain the finished product.

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