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  • Clotrimazole Raw Materials Powder

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    Product Overview:

    Clotrimazole, an organic compound with the chemical formula C22H17ClN2, is a broad-spectrum antifungal drug with good antimicrobial effects on a variety of fungi, especially Candida albicans, and its mechanism of action is to inhibit the synthesis of fungal cell membranes as well as affecting their metabolic processes.

    Clotrimazole Raw Materials Powder Attributes

    Clotrimazole Raw Materials Powder

    CAS:23593-75-1

    MF: C22H17ClN2
    Clotrimazole Raw Materials

    MW: 344.84

    EINECS: 245-764-8

    Specification​: 99% min Clotrimazole Powder

    Sample: Clotrimazole Powder

    Packaging:1kg/bag, 25kg/drum

    Brand: Henrikang

    Appearance: White Powder

    Storage: Cool Dry Place

    Shelf Life: 2 Years

    Test Method: HPLC

    Clotrimazole Raw Materials Powder Details

    Clotrimazole Raw Materials Powder Usage and Synthesis.

    Broad-spectrum antifungal. Used for systemic fungal infections and also topically for localised fungal infections.

    Clotrimazole is an antifungal dermatological drug for the treatment of deep and superficial fungal diseases caused by sensitive bacteria, such as cryptococcal meningitis, Candida pneumonia, enteritis, histoplasmosis, tinea corporis, tinea cruris, etc., of which the treatment of Candidiasis is the most effective, and ringworm, regardless of whether the topical or internal use is ineffective.

    Clotrimazole Powder

    Uses and functions of Clotrimazole Powder.

    (1) By reducing the activity of cytochrome P450, thus inhibiting the biosynthesis of sterols such as ergosterol in fungal cell membranes, damaging fungal cell membranes and altering their permeability, causing leakage of important intracellular substances.

    (2)Clotrimazole can also inhibit the biosynthesis of triacylglycerol and phospholipids in fungi.

    (3)It can also inhibit the activity of oxidase and peroxidase, leading to excessive accumulation of hydrogen peroxide in the cell, causing fungal subcellular structural degeneration and cell necrosis.

    (4) Inhibits the transformation of Candida albicans from spores to invasive hyphae.

    Clotrimazole Raw Materials

    Pharmacological Effects of Clotrimazole Raw Powder.

    In vivo and in vitro clotrimazole on Candida, Cryptococcus, Aspergillus, Algae, dermatophytes, etc. have good bacteriostatic effect, the efficacy of superficial fungal diseases of the skin is similar to ashwagandha, the efficacy of the deep fungal diseases is similar to amphotericin B, the visceral pathogenic fungi such as Candida albicans, new cryptococcus, coccus spores, and histopathogenic fungi, are good, on Candida albicans effect is stronger than that of the bacteriostatic fungus, the effect of Candidatus albicans than that of the mycotoxin. It has good effect on Candida albicans than mycotoxin.

    Fungus is not easy to produce drug resistance to this product. It is easily absorbed internally and can be used internally for the treatment of systemic and deep fungal infections such as Aspergillus fumigatus, Candida albicans, Cryptococcosis, Coccidioidomycosis, Histoplasmosis (dogs, cats) and fungal septicaemia.

    For serious deep fungal infections, it is suitable to be used in combination with amphotericin B. External use can also be used to treat superficial fungal infections, such as ringworm and livestock ringworm, ringworm, etc.It is not effective for ringworm of the head. Clotrimazole is also effective against certain gram-positive bacteria and trichomonas vaginalis.

    Clotrimazole Raw Powder

    Production method of Clotrimazole.

    It is obtained from o-chlorobenzoic acid by esterification, addition, hydrolysis, chlorination and condensation. It can also be obtained from o-chlorotoluene by chlorination to o-chlorotrichlorobenzene, then condensed with benzene in the presence of aluminium trichloride to produce diphenyl-(2-chlorophenyl)chloromethane, and finally condensed with imidazole to obtain clotrimazole.

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