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Posaconazole Powder Raw Material
Product Overview:
High Purity 99% Posaconazole Raw Material Powder, Supplier Wholesale Posaconazole Raw Powder.Posaconazole Powder China Manufacturer Supply Posaconazole Raw Powder CAS 171228-49-2, MF: C37H42F2N8O4, Posaconazole is effective in preventing invasive fungal infections.Supplier Wholesale Posaconazole Raw Powder.
Posaconazole Powder Raw Material Attributes
CAS: 171228-49-2
MF: C37H42F2N8O4
MW: 700.78
EINECS: 682-747-8
Specification: 99% min Posaconazole
Sample: Posaconazole Powder
Packaging:1kg/bag, 25kg/drum
Brand: Henrikang
Appearance: White Powder
Storage: Cool Dry Place
Shelf Life: 2 Years
Test Method: HPLC
Posaconazole Powder Raw Material Details
Posaconazole Raw Materials Usage and Synthesis
High Purity 99% Posaconazole Raw Material Powder, Supplier Wholesale Posaconazole Raw Powder.Posaconazole Powder China Manufacturer Supply Posaconazole Raw Powder CAS 171228-49-2, MF: C37H42F2N8O4, Posaconazole is effective in preventing invasive fungal infections.
Uses and functions of Posaconazole Powder
- However, their status as the main prophylactic medication remains unchanged.
- Posaconazole Raw Materials Echinocandins (caspofungin, anifungin, micafungin) have a narrower antifungal spectrum than triazoles and polyenes.
- Posaconazole Raw Powder is mainly used for the treatment of Candida infections, which has the advantages of good efficacy and significant safety, but the non-oral dosage form is a major disadvantage.
- Posaconazole Raw Materials (amphotericin B and its liposomes) are no longer the "gold standard" for the treatment of deep-seated fungal infections, and the decline in the therapeutic status of polyenes is mainly due to their significant adverse effects.
- Posaconazole Powder is used clinically for the treatment of Aspergillosis, Sjögrenomycosis, Fusarium, and some fluconazole-resistant Candida spp. infections.
Pharmacological Effects of Posaconazole Raw Powder
- Posaconazole exerts its antifungal activity by inhibiting ergosterol biosynthesis.
- Ergosterol is an important component of fungi necessary for maintaining the structural integrity of cell membranes and for the function of some membrane-associated proteins, as well as an essential trace substance in the fungal cell cycle.
- Posaconazole blocks ergosterol synthesis by inhibiting the fungal pigment P45014 alpha-demethylase and causing the accumulation of 14 alpha-methylsterols, among others, and the extent of the blockage is related to the susceptibility of the test strain and the dose of posaconazole.
- Mutant strains of Candida albicans are resistant to itraconazole (ITC), fluconazole (FLC), and voriconazole (VRC) due to mutations in the 14α-demethylase enzyme, but are still sensitive to this product.
- It inhibits sterol biosynthesis in Aspergillus fumigatus and Aspergillus flavus more effectively than ITC.
Production method of Raw Posaconazole Powder