Fluocinolone Acetonide Raw Materials Powder

CAS:67-73-2

MF: C24H30F2O6

MW: 452.49

EINECS: 200-668-5

Specification​: 99% min Fluocinolone Acetonide Powder

Sample: Fluocinolone Acetonide Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance: White Powder

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Fluocinolone Acetonide Powder Usage and Synthesis.

Botulinum toxin acetate, also known as fluoride acetate, fluocinonide, fluoride deinflammatory Shusong, skin light, fluoride easy, Xian Nai Le, acetonide fluoride Xinlong, for the current China's topical corticosteroid in the most significant efficacy and side effects of a smaller one, the dermis can be made to capillary contraction, inhibition of proliferation of connective tissue cells or regeneration; but also stabilise intracellular lysosomal membranes, to prevent the release of intracellular lysosomal enzymes and histamine release caused by tissue damage.

Its anti-inflammatory effect for hydrocortisone 100 times, the use of the lowest concentration (0.025%) that have obvious effect, and the effect is rapid, can be significantly reduced or cured within a few days, the role of itching is good. Skin lightening acetate is mainly used for glucocorticoid effective skin diseases, such as contact dermatitis, atopic dermatitis, seborrheic dermatitis, neurodermatitis, solar dermatitis, eczema (especially infantile eczema), pruritis, psoriasis, discoid lupus erythematosus, lichen planus, otitis externa and so on.

Combined with neomycin and other antibacterial agents can treat purulent skin diseases. With 0.025-0.05% ointment, lotion applied to the swabbed affected area, 2-3 times a day, can be gently rubbed to promote its penetration into the skin.

Uses and functions of Fluocinolone Acetonide.

For the treatment of eczema, neurodermatitis, pruritus, contact dermatitis, psoriasis and solar dermatitis.

For contact dermatitis, allergic dermatitis, seborrheic dermatitis, neurodermatitis, solar dermatitis, eczema, psoriasis, lichen planus and pruritus.

For atopic dermatitis, contact dermatitis, seborrheic dermatitis and eczema, etc.

Fludioxonil acetate is a synthetic, fluorinated, potent steroid. Topical application can make the dermal capillary contraction, inhibit the proliferation or regeneration of epidermal cells, inhibit the newborn of fibroblasts in the clitoral tissue, stabilise the intracellular lysosomal membrane, with anti-inflammatory and antipruritic effects.

Pharmacological Effects of Fluocinolone Acetonide Raw Materials .

Fluocinonide is a fluorinated glucocorticoid.

The 0.01% topical preparation is a moderately potent and the 0.025% topical preparation is a potent glucocorticoid. It can make the dermal capillaries contract, inhibit the proliferation or regeneration of epidermal cells, inhibit the proliferation of connective tissues, stabilise the intracellular lysosomal membrane, reduce inflammatory exudation, and inhibit the formation and release of histamine and other inflammatory mediators, which has the effect of anti-allergenicity, anti-inflammation and antipruritic.

Topical corticosteroid, its efficacy is significant and side effects are small, local application of the skin, mucous membrane inflammation, itching and skin allergic reactions are effective. The effect is rapid and the effect of itching is good. The application of very low concentration (0.025%), that is, there are obvious therapeutic effects. Stop itching effect is good.

Production method of Fluocinolone Acetonide Raw Powder.

Sample preparation: 1. Preparation of control solution

Take about the appropriate amount of flutriafol acetate control, weigh it precisely, put it in a 50mL measuring flask, add methanol 35mL to make it dissolve, dilute it with water to the scale, shake it well, measure 10mL of the solution and 5mL of the internal standard solution, put it in a 25mL measuring flask, dilute it to the scale by adding the mobile phase, shake it well.

2. Preparation of test solution

Take about 14mg of the product, weigh it precisely, put it in a 100mL measuring flask, add 60mL of methanol and 10mL of acetonitrile to make it dissolve, dilute it with water to the scale, shake it well, take 10mL of the solution and 5mL of the internal standard solution, put it in a 50mL measuring flask, dilute it to the scale by adding mobile phase, shake it well.

3. Preparation of internal standard solution

Take appropriate amount of hydrocortisone, add methanol to make a solution containing about 0.12mg per 1mL, that is obtained.

Note: "Precision weighing" means that the weight should be accurate to one thousandth of the weight taken. "Precision measurement" means that the accuracy of the volume taken should be in accordance with the national standards for the volume of the pipette precision requirements.

Procedure: Pipette 20μL of each of the above control solution and test solution into high performance liquid chromatograph, measure at 240nm with ultraviolet absorption detector, record the chromatogram, and calculate the content by peak area according to the internal standard method.