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  • Pharmaceutical Bulk Metformin HCL Powder

    • Pharmaceutical Bulk Metformin HCL Powder
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    Product Overview:

    Metformin hydrochloride is a biguanide oral hypoglycemic drug, also known as metformin hydrochloride, gwashiramine, medi-com, the hypoglycemic effect is weaker than phenyl ethylguanidine, the main effect is to reduce the secretion of glucagon of A-cells to promote the conversion of glucose into glycogen, and has the property of not stimulating the pancreatic β-cells to secrete insulin. It is prohibited in congestive heart failure, hepatic and renal insufficiency, diabetes mellitus with ketoacidosis and acute infection; pregnant women should be cautious of use.

    Pharmaceutical Bulk Metformin HCL Powder Attributes

    Pharmaceutical Bulk Metformin HCL Powder

    CAS:1115-70-4

    MF: C4H12ClN5

    Bulk Metformin HCL

    MW:165.62

    EINECS:214-230-6

    Specification: 99% min Metformin HCL Powder

    Sample: Metformin HCL Powder

    Packaging:1kg/bag, 25kg/drum

    Brand: Henrikang

    Appearance: White Powder

    Storage: Cool Dry Place

    Shelf Life: 2 Years

    Test Method: HPLC

    Pharmaceutical Bulk Metformin HCL Powder Details

    Metformin HCL Powder Usage and Synthesis.

    The mechanism of action of Metformin HCL in lowering glucose is as follows:

    1. Increase insulin sensitivity of peripheral tissues and increase insulin-mediated glucose utilisation.

    2. Increase glucose utilisation in non-insulin-dependent tissues, such as brain, blood cells, renal medulla, intestines and skin.

    3. Inhibits hepatic gluconeogenesis and reduces hepatic glucose output.

    4. Inhibit glucose uptake by intestinal wall cells.

    5. Inhibit cholesterol biosynthesis and storage, reduce blood triglyceride and total cholesterol level.

    Metformin HCL Powder

    Uses and functions of Metformin HCL.

    Clinically, metformin hydrochloride is mainly used for the treatment of type II diabetes mellitus patients with unsatisfactory dietary control alone, especially those who are obese and accompanied by hyperinsulinaemia, with this drug not only has the effect of hypoglycemia, but also may have the effect of reducing body weight and hyperinsulinaemia.

    For some patients with poor efficacy of sulfonylureas can be effective, such as with sulfonylureas, small intestine glucosidase inhibitors or thiazolidinediones glucose-lowering drugs in combination, the effect is better than that of the respective single use.

    It can also be used in insulin-treated patients to reduce insulin dosage.

    Metformin HCL is a hypoglycemic drug.Metformin HCL can reduce fasting and postprandial hyperglycemia in patients with type II diabetes mellitus, and HbAlc can be decreased by 1% to 2%.The mechanism of hypoglycemia of this product may be:

    ①Increase the sensitivity of peripheral tissues to insulin and increase insulin-mediated glucose utilisation. ②Increase glucose utilisation in non-insulin-dependent tissues, such as brain, blood cells, renal medulla, intestines and skin.

    (iii) Inhibits hepatic gluconeogenesis and decreases hepatic glucose output.

    (iv) Inhibits glucose uptake by intestinal wall cells.

    Bulk Metformin HCL

    Pharmacological Effects of Metformin HCL.

    Metformin HCL is a hypoglycaemic drug. It can reduce fasting and postprandial hyperglycemia in patients with type II diabetes mellitus, and HbAlc can be decreased by 1%-2%.The mechanism of hypoglycemia of this product may be:

    1, Increase the sensitivity of peripheral tissues to insulin, increase insulin-mediated glucose utilisation.

    2、Increase glucose utilisation in non-insulin-dependent tissues, such as brain, blood cells, renal medulla, intestines and skin.

    3、Inhibit hepatic gluconeogenesis and reduce hepatic glucose output.

    4、Inhibit the uptake of glucose by intestinal wall cells.

    5、Inhibit cholesterol biosynthesis and storage, reduce blood triglyceride and total cholesterol levels.

    Different from the action of insulin, this product does not promote fat synthesis, no significant hypoglycaemic effect on normal people, type II diabetes mellitus when applied alone generally does not cause hypoglycaemia.

    Bulk Metformin HCL Powder

    Production method of Bulk Metformin HCL Powder.

    Obtained by forming a salt of dimethylamine and then reacting with dicyandiamide.

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