Pharmaceutical Bulk Obeticholic Acid Powder

CAS:459789-99-2

MF: C26H44O4

MW:420.63 

EINECS:810-245-2

Specification: 99% min Obeticholic Acid Powder

Sample: Obeticholic Acid Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance: White Powder

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Obeticholic Acid Powder Usage and Synthesis.

In a rat model of biliary depressions, ObeticholicAcid promotes bile flow and protects hepatocytes from LCA-induced acute necrosis.

In WD-fed DBA mice, ObeticholicAcid (p.o.) ameliorated proteinuria and altered renal structure and modulated renal inflammation and oxidative stress.

In thioacetamide (TAA)-intoxicated and bile duct ligated (BDL) rats, ObeticholicAcid (30 mg/kg p.o.) restored the downstream signalling pathway of FXR by decreasing the total IHVR and reduced portal pressure without producing deleterious systemic hypotension.

Uses and functions of Obeticholic Acid.

Obecholic acid, as a prescription drug, has a number of effects and effects. First, it is able to help patients reduce liver fibrosis, alanine aminotransferase (AST) and aspartate aminotransferase (ALT) indicators. After taking obecholic acid, patients can reduce the degree of liver disease and is expected to delay the progression of the disease. At the same time, obecholic acid can also reduce the symptoms and discomfort caused by liver disease, such as fatigue and loss of appetite.Secondly, obecholic acid can also help patients lower blood cholesterol levels. It can promote cholesterol metabolism and excretion, thereby reducing blood cholesterol levels. In clinical trials, monitoring of patients taking obecholic acid showed a significant reduction in blood cholesterol levels.

In addition, obecholic acid can also help patients control blood sugar levels, especially those with diabetes. It can promote the absorption and utilization of glucose by liver cells and increase insulin sensitivity, thus helping to control blood sugar levels. Clinical trials in diabetic patients have also shown that obecholic acid can significantly reduce fasting blood sugar levels in patients.

Pharmacological Effects of Obeticholic Acid.

PBC is a disease caused by chronic cholestasis due to bile duct dysplasia or bile acid metabolism disorders, which results in lipolysis of cell membranes, altered permeability, and efflux of cellular contents, and ultimately progresses to hepatic fibrosis and cirrhosis.

Currently, ursodeoxycholic acid is the main drug used in the clinical treatment of PBC, which mainly stimulates hepatobiliary secretion through the intracellular signalling molecule mitogen-activated protein kinase (MAPK) pathway, and protects epithelial cells from bile acid damage.

Production method of Bulk Obeticholic Acid Powder.

The synthesis of obeticholic acid started from cheap and readily available goose deoxycholic acid, 7α-OH of goose deoxycholic acid was selectively oxidised to 7-carbonyl by PCC reagent at room temperature in the medium CHCl3/Cl2CH2 to produce compound 1; in the same medium CHCl3/Cl2CH2, compound 1 was reacted with 3, 4-dihydro -2H pyran to produce compound 2; compound 2 was alkylated by ethyl iodide (Et-I) in the presence of n-butyllithium (n-BuLi) and the enolated structure LDA/HMPA to produce 6-ethyl, and then pyridine p-toluenesulfonate (PPTS) to produce compound 3; and the stereoselective reduction of compound 3 from the backside by sodium borohydride (NaBH4) to produce compound 6-ethyl Goose Deoxycholic Acid, or Obeticholic Acid.