β-Nicotinamide Mononucleotide Raw Material NMN Powder

CAS: 1094-61-7

MF: C11H15N2O8P

MW: 334.22

EINECS: 214-136-5

Specification​: 99% min β-Nicotinamide Mononucleotide

Sample: NMN Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance: White Powder

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

β-Nicotinamide Mononucleotide Raw Material Usage and Synthesis

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Uses and functions of β-Nicotinamide Mononucleotide Raw Powder

In mammals, β-nicotinamide mononucleotide powder is produced from nicotinamide (Nam) catalysed by Nampt (a protease in vivo), and subsequently nicotinamide mononucleotide is catalyzed by nicotinamide mononucleotide adenylyltransferase to produce NAD+.

Nicotinamide mononucleotide is a direct way to replenish NAD+. It is by significantly enhancing the ability to repair intracellular DNA damage that nicotinamide mononucleotide ultimately reverses the effects of aging.

Nicotinamide mononucleotide is converted into nicotinamide adenine dinucleotide (NAD), which is essential for energy metabolism in the body. In mouse tests, it has been demonstrated that nicotinamide mononucleotide activates a gene called acetylase in the body, which has been shown to be effective in prolonging life and treating diabetes.

NAD is a substance that can be produced by the human body, and studies have shown that the amount of NAD in the body decreases with age.

Pharmacological Effects of NMN Raw Powder

Nicotinamide mononucleotide, also known as β-nicotinamide mononucleotide (NMN), is a synthetic substrate for coenzyme I. Meanwhile, NMN has also been used in anti-aging research.

Studies have shown that β-NMN can also play a regulatory role in insulin secretion and has an effect on the expression level of mRNA. β-NMN has a wide range of applications in the field of medical therapy.

β-Nicotinamide mononucleotide is a product of the extracellular nicotinamide phosphoribosyltransferase (eNAMPT) reaction and a key NAD+ intermediate.

It improves glucose tolerance by restoring NAD+ levels in HFD-induced T2D mice. It also enhances hepatic insulin sensitivity and restores gene expression associated with oxidative stress, inflammatory responses and circadian rhythms partly through SIRT1 activation.

Production method of Raw NMN Powder

• Add 150 ml of phosphate buffer solution to a 500 ml four-necked flask. 2 g of magnesium chloride, 10 g of ATP, 7 g of ribose, and 10 g of nicotinamide were added all at once and held at 35°C with stirring.
• The pH of the reaction system was detected and pH = 8.0 was adjusted with 10% Na2CO3 solution, and 1 g of RK enzyme powder and 2 g of NAMPT enzyme powder were added and stirred to dissolve.
• The reaction was stirred at 200 rpm at 37 °C, and the conversion rate of the reaction was monitored using liquid chromatography-mass spectrometry, and after 6 h of reaction, the reaction was stopped by detecting that ATP had been consumed.
• By further filtration, adsorption on HZ-818-type macroporous resin, lyophilization, and recrystallization from ethanol and water, β-nicotinamide mononucleotide-nicotinamide mononucleotide NMN can be obtained in 70% yield.