Pharmaceutical Bulk L-carnitine Powder

CAS:541-15-1

MF: C7H15NO3

MW:161.2

EINECS:208-768-0

Specification: 99% min L-carnitine Powder

Sample: L-carnitine Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance: White Powder

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

L-carnitine Powder Usage and Synthesis.

Carnitine is a type of B vitamin that is structured like an amino acid, which is why some people also classify it as an amino acid. Its main role is to help transport long-chain fatty acids for energy.

This prevents the accumulation of fat in the heart, liver and skeletal muscles.

Synthetic carnitine comes in three forms: levocarnitine, dextrocarnitine and racemic, with levocarnitine being the more effective.

L-carnitine is a compound with a variety of physiological active functions, its main function is to promote fatty acid β-oxidation; it can also regulate the ratio of acyl groups in the mitochondria, affecting energy metabolism; L-carnitine can participate in the transport of branched-chain amino acid metabolites, thus promoting the normal metabolism of branched-chain amino acids.

In addition, L-carnitine plays a role in the elimination and utilisation of ketone bodies, and can be used as a biological antioxidant to remove free radicals, maintain the stability of the membrane, and improve the immunity of animals as well as their ability to resist disease and stress.

Recent studies have shown that L-carnitine and acetyl L-carnitine play an important role as carriers of energy metabolism in sperm mitochondria, scavenging ROS and protecting sperm membrane function.

Oral L-carnitine and acetyl L-carnitine can increase the total number of forward-moving spermatozoa and total number of motile spermatozoa in patients with oligozoospermia and weak spermatozoa, and improve the clinical pregnancy rate of the female partner, and it is safe and effective.

Clinical experimental studies at home and abroad have shown that carnitine treatment of male infertility is a new breakthrough in the field of male infertility drug therapy in recent years, and its in-depth study is very necessary to further elucidate its mechanism of action and clarify its indications.

Uses and functions of L-carnitine.

L-carnitine is a newly approved food fortifier in China. It is mainly used to fortify soya-based infant foods and promote the absorption and utilisation of fat.

D-type and DL-type have no nutritional value. China stipulates that it can be used in biscuits, drinking liquids and milk beverages with the use amount of 600-3000mg/kg; in solid beverages, drinking liquids and capsules with the use amount of 250-600mg/kg; in milk powder with the use amount of 300-400mg/kg; and in infant formula food with the use amount of 70-90mg/kg (in terms of L-carnitine, 1g of tartaric acid salt is equivalent to 0.68g of L -Carnitine).

Used in drugs, nutritional health products, functional beverages, feed additives, etc.

L-carnitine is a newly approved animal nutritional fortifier in China. It is mainly used to fortify protein-based additives, and can promote the absorption and utilisation of fat.D-type and DL-type have no nutritional value. The dosage is 70-90mg/kg (1g of tartrate is equivalent to 0.68g of L-carnitine).

Pharmacological Effects of L-carnitine Raw.

L-carnitine is a vitamin-like substance that encourages the conversion of fat into energy and has no toxic side effects on the human body.

The most prominent physiological function of L-carnitine is that it acts as a carrier for fatty acid transport, transferring medium and long chain fatty acids in the form of acetyl carnitine from outside the cellular mitochondrial membrane to the inner membrane, where they are oxidised in the mitochondrial matrix to produce energy.

For example, it seems to be a forklift, can shovel up fat into the fuel furnace to burn to provide energy, acted as a fat to the mitochondria of the "porter", is internationally recognised as a safe and non-toxic fat loss of nutrient-enhancing agents, the international recommendation of 1-5 grams of L-carnitine consumption is more suitable.

It is especially suitable for people to do aerobic exercise to reduce fat, with obvious effect. L-carnitine is produced in the liver and kidney of human body and stored in muscle, semen, brain and heart.

Production method of Bulk L-carnitine Powder.

(1) Extraction method. Naturally occurring in a variety of meats and milks, L-carnitine can be extracted directly from L-carnitine-containing beef and cow's milk. Literature reports that 0.6g of crystalline carnitine can be obtained from 450g of beef extract, and 100g of lactose powder containing 2% L-carnitine can be extracted from 56kg of cow's milk.However, the extraction method is more costly and less economically reasonable.

(2) Microbial fermentation method. Studies have shown that L-carnitine also exists in many microorganisms, and L-carnitine can be accumulated by using microorganisms such as yeast, Aspergillus, Penicillium, Rhizopus and other microorganisms liquid deep culture or solid fermentation. However, due to the complexity of strain screening, the current level of fermentation is still relatively low. It was reported that 2% DL-carnitine was used as raw material and fermented at 25°C for 44h to accumulate 0.4% L-carnitine.