Nutritional Supplements Drugs Coenzyme Q10 Raw Materials Powder

CAS:303-98-0

MF: C59H90O4

MW: 863.34

EINECS:206-147-9

Specification​: 99% min Coenzyme Q10 Powder

Sample: Coenzyme Q10 Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance: Orange Powder

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Coenzyme Q10 Powder Usage and Synthesis.

Coenzyme Q10 is a small molecule fat-soluble quinone organic compound widely found in plant and animal cells, with a structure similar to that of vitamin K. Used alone or in combination with vitamin E, it is a powerful antioxidant. It is necessary to drive the body's energy production (ATP) cycle. Has the function of promoting oxidative phosphorylation reactions and protecting the structural integrity of biological membranes. The number of isoprenyl units in the side chain of different sources of coenzyme Q varies, and in humans and mammals it is 10 isoprenyl units, so it is called coenzyme Q10.Coenzyme Q plays an important role in proton translocation and electron transfer in the respiratory chain in vivo, and it is an activator of cellular respiration and metabolism, and an important antioxidant and non-specific immune enhancer.

Uses and functions of Coenzyme Q10.

Coenzyme Q10 is used as an endogenous cellular antioxidant; it is an essential component of the ;electron transfer chain. It is also a coenzyme analogue used as an adjunctive therapy for congestive heart failure, arrhythmias, sinus tachycardia, premature beats, hypertension and cancer; and in the comprehensive treatment of acute and chronic viral hepatitis and subacute hepatic necrosis. In addition, it is also tried in primary and secondary aldosteronism, cerebrovascular disorders and haemorrhagic shock.

It activates the nutrition of human cells and cellular energy, and has the ability to improve human immunity, enhance antioxidant, delay aging and enhance human vitality. In addition, recent studies have shown that the product also has an anti-tumour effect, clinical for advanced metastatic cancer has a certain degree of efficacy, in the prevention of coronary heart disease, alleviate periodontitis, the treatment of duodenal ulcers and gastric ulcers, to enhance the body's immune function as well as alleviate angina pectoris has a significant effect. It is widely used in pharmaceuticals, cosmetics, food additives and other industries.

Pharmacological Effects of Coenzyme Q10.

1、It can reduce the weakening of myocardial contractility and the reduction of phosphocreatine and adenosine triphosphate content in acute ischemia, keep the morphology and structure of mitochondria of ischemic cardiomyocytes, and have a certain protective effect on ischemic myocardium.

2、It increases cardiac output and reduces peripheral resistance, which is conducive to the treatment of anti-heart failure, and may inhibit the synthesis and secretion of aldosterone and block its effect on renal tubules.

3、When perfusing the isolated ventricular muscle of animals under hypoxic conditions, it can shorten the duration of its action potential and produce ventricular arrhythmia threshold higher than that of control animals.

4、It can make the peripheral vascular resistance decrease, and have anti-aldosterone effect.

5, Coenzyme Q10 has anti-adriamycin cardiotoxic effect and hepatoprotective effect.

Product Method of Coenzyme Q10.

Method I, alcohol - alkali saponification method of saponification solution preparation take pig heart residue, press dry weighing, according to the dry residue weight plus 300g / L industrial pyrogallic gallic acid, stir, add alcohol - alkali solution (dry residue weight of 3-3.5 times the amount of ethanol, 320g / L sodium hydroxide), heating and stirring reflux 25-30min, cooled quickly to room temperature, saponification solution. Pig heart residue [NaOH] → [pyrogallic gallic acid, ethanol] saponification liquid concentrate preparation Take the saponification liquid, immediately add its volume 1/10 amount of petroleum ether or 120 gasoline extracted 3-4 times, stirring, stratification, get the extract. Wash to nearly neutral, at 40 ℃ below the concentration to the original volume of 1/10, cooling, -5 ℃ below the static overnight, filtration, get the concentrate. Saponification solution [petroleum ether] → extract [<40 ° C] → concentrate coenzyme Q10 refined products preparation will be concentrated over silica gel column chromatography, successively eluted with petroleum ether, 10% ethyl ether - petroleum ether, collect the eluent, recovery of solvent, get yellow oil. Heating anhydrous ethanol to dissolve, filtration, filtrate static, cooling crystallisation, vacuum drying, coenzyme Q10 refined products. Concentrate [silica gel column, ether - petroleum ether] → eluent [anhydrous ethanol] → coenzyme Q10 refined products

Method II, alcohol - ether mixed solvent extraction method coenzyme Q10 crude product preparation take pig heart residue, add 1.5 times the amount of V ethanol: V ether = 3: 1 mixed solvent, heating extraction 3-4 times, each time 15-20min, cooled to room temperature, filtration, and combined with the extract. Concentrate, add appropriate amount of water, add petroleum ether extraction, the extract is concentrated, the concentrate is yellow oil, that is, Coenzyme Q10 crude products. Preparation of coenzyme Q10 finished products take coenzyme Q10 crude products, add acetone to dissolve, set -10 ℃ below the precipitation impurities, filtration, filtrate evaporation of acetone, add a small amount of petroleum ether to dissolve, over the silica gel column chromatography separation, add anhydrous ethanol crystallisation, coenzyme Q10 finished products. Coenzyme Q10 crude product [silica gel column] → [acetone, anhydrous ethanol] Coenzyme Q10 finished product