Rafoxanide Raw Materials powder Rafoxanide

CAS:22662-39-1

MF:C19H11Cl2I2NO3

MW:626.01

EINECS:245-148-9

Specification​: 99% min Rafoxanide powder

Sample:Rafoxanide powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance:white powder

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Rafoxanide powder Usage and Synthesis.

Iodoxylamine is mainly used in the treatment of adult liver fasciola of horse, cattle and sheep, and may have a strong affinity with blood proteins, so the killing effect on larvae is poor. However, it has a high repellent activity on children over 6 weeks of age in cattle and sheep, which may be effective just after the drug is used, and it is also likely that because the drug effect lasts for a long time in the blood, the drug activity in the blood has accumulated to a high concentration when the fluke begins to ingest the blood, so as to play a insecticidal effect.

Uses and functions of Rafoxanide.

Iodoxylamine is a highly effective antihelminth drug, ‌ is mainly used to control liver fasciola, ‌ fasciola adult and larval disease of cattle and sheep. In addition to the obvious effect on fasciola hepatica ‌, ‌ iodosalsamide also had good effects on Trichostrongylus sanguinis, ‌ giant fasciola and sheep fly maggot. ‌ The drug is widely used in the veterinary field, ‌ because it can effectively solve the problems related to worm infection, ‌ at the same time provides a variety of ways of use, such as ‌ irrigation, ‌ drinking water, ‌ makes the use more convenient, ‌ has the characteristics of high efficiency and low toxicity. ‌

Chemical properties of iodoethersalide include solubility in acetone, ‌ slightly soluble in ethyl acetate, ‌ slightly soluble in methanol, and ‌ with a low solubility in water. ‌ The physical and chemical properties of the drug determine its application in a particular environment. ‌

Pushan Industrial (Shaanxi) Co., LTD is one of the manufacturers of iodoxylamine. ‌ The company integrates chemical R&D, ‌ chemical product development, ‌ customization as well as production and management. ‌ provides iodoxylamine in 25 kg packs with the purity of ‌ up to 99%. ‌ shows the universality and importance of iodoxylamine in the market. ‌

Pharmacological action of Rafoxanide.

1. Antiparasitic effect
‌Interferes with energy metabolism‌
By uncoupling the oxidative phosphorylation process, inhibits the phosphorylation of the parasite's mitochondria, blocks ATP synthesis, and causes the parasite's energy metabolism to fail and die.

‌Broad-spectrum anti-trematode activity‌
It is effective against liver flukes, giant flukes, contorted haemonchus and sheep fly larvae.

‌Long-acting properties‌
It has strong binding ability with blood proteins and a long duration of efficacy.

2. Anti-tumor effect
‌BRAF V600E inhibition‌
It can specifically inhibit the BRAF V600E mutant protein associated with colorectal cancer.

‌Potential anti-cancer application‌
It is currently in the experimental stage of cancer research.

3. Other characteristics
‌Veterinary use‌
It is mainly used to prevent and treat parasitic infections in ruminants such as cattle and sheep.

‌Research limitations‌
Most of the existing data come from in vitro or animal experiments, and clinical research evidence is limited

Product method of Bulk Rafoxanide.

Presumed synthetic route
‌Preparation of key intermediates‌
Use 3-chloro-4-(4-chlorophenoxy)aniline as the starting material and carry out amidation reaction with 2-hydroxy-3,5-diiodobenzoyl chloride.

‌Iodination reaction‌
It is possible to use iodine/oxidant system to carry out directional iodination modification of benzene ring

‌Refining process‌
The off-white to light brown powder (melting point 173-176℃) that meets the pharmacopoeia standards is obtained by recrystallization through acetone/water mixed solvent