Veterinary Sulfamethazine Powder CAS 57-68-1 Raw Materials

CAS: 57-68-1

MF: C12H14N4O2S

MW: 278.33

EINECS: 200-346-4

Specification​: 99% min Sulfamethazine 

Sample: Sulfamethazine Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance: White Powder

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Portal:https://henrikang.en.made-in-china.com/

Sulfamethazine Powder Usage and Synthesis.

Sulfamethazine PowderWhite or yellowish crystal or powder. Melting point 176°C. Sulfamethazine CAS 57-68-1 is almost insoluble in water, 
Sulfamethazine Raw Materials is used for the prevention and treatment of staphylococcus and Streptococcus solubilis and other infections, and it has an Sulfamethazine Powder is used for the prevention and treatment of staphylococcus and Streptococcus solubilis and other infections, and it has an inhibitory effect on hemolytic streptococcus and pleuronidase coccus, etc. 

Sulfamethazine Powder is mainly used for the treatment of Sulfamethazine Powder is mainly used to treat avian cholera, avian typhoid fever, chicken Sulfamethazine Powder is mainly used to treat avian cholera, avian typhoid fever, chicken coccidiosis and so on.

Sulfadimethoxine is a broad-spectrum bacteriostatic agent, and its p-aminobenzoic acid (PABA), which can act competitively with PABA on the enzyme of folatesynthesis in the bacterial body, thus preventing the process of synthesizing folates needed by bacteria as raw material of PABA, and decreasing the amount of metabolically active tetrahydrofolate, which is necessary for the bacterial synthesis of purine, thymine nucleoside and deoxyribonucleic acid (DNA).

Therefore, sulfadimethoxine inhibits the growth and reproduction of bacteria. The effect of sulfadimethoxine is antagonized by PABA and its derivatives (procaine, bupivacaine), and also by the presence of pus and tissue breakdown products, which provide essential substances for bacterial growth.

Uses and functions of Sulfamethazine Powder.

It is used for the prevention and treatment of staphylococcus and streptococcus solani infections, and has inhibitory effect on hemolytic streptococcus and pleurisy coccus, mainly used for the treatment of avian cholera, avian typhoid fever, chicken coccidiosis and so on.

UsesVeterinary medicine, used for analyzing and testing. UsesAn antimicrobial sulfonamide; induces CYP3A4 expression, as well as acetylation via N-acetyltransferase;

Exhibits sex-dependent pharmacokinetics, producing metabolic changes through the male-specific isoform CYP2C11; inhibits dihydrofolate synthase to achieve the effect of blocking folate synthesis Usage Inhibits hemolytic streptococci, pneumococci, and meningitis, etc.

Pharmacological Effects of Sulfamethazine Powder.

White or yellowish crystal or powder. Melting point 176℃. Almost insoluble in water (solubility: 29 ° C, 150mg/100ml; 37 ° C, 192mg/100ml), the product in hot ethanol, insoluble in ether, soluble in dilute acid or dilute alkali solution. No smell, slightly bitter taste, gradually darken color when exposed to light.

Production method of Sulfamethazine Powder.

It is obtained by cyclization of sulfamidine with acetylacetone.

A mixture of p-acetamidobenzenesulfonyl chloride (1.0 mmol) and cyclamidine (1.5 mmol) in water (1 mL) was stirred for 5 minutes and the resulting precipitate was collected by filtration. It was transferred to a round-bottomed flask and 2 mL of a concentrated solution of hydrochloric acid and 4 mL of water. The reaction mixture was gently boiled at 100°C for one hour.

The solution obtained in an ice bath was cooled and alkalized using saturated aqueous NaHCO3 solution. The granular precipitate was filtered, washed with water and dried in air to give the product sulfadimethoxine.