Neomycin Sulfate CAS 1405-10-3 Raw Materials Powder

CAS: 1405-10-3

MF: C23H48N6O17S

Specification​: 99% min Neomycin Sulfate

Sample:  Neomycin Sulfate Powder

Brand: Henrikang

Appearance: White Powder

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Neomycin Sulfate Powder Usage and Synthesis:

Neomycin sulfate is an aminoglycoside antibiotic. The product has good antibacterial action against Staphylococcus (methicillin-sensitive strains), Corynebacterium, Escherichia coli, Klebsiella, Proteus and other Enterobacteriaceae bacteria, but poor activity against streptococcus, Streptococcus pneumoniae and Enterococcus of each group. Pseudomonas aeruginosa, anaerobic bacteria and other drug resistant to this product. Neomycin Sulfate Powder is a white or off-white powder, odorless and very easy to induce moisture,  Neomycin Sulfate CAS 1405-10-3 is very soluble in water. Neomycin Sulfate is a broad-spectrum antibacterial drug,  the mechanism of action of Neomycin Sulfate is to inhibit the synthesis of bacteriophage proteins.

Neomycin Sulfate Powder has a high concentration in the intestinal tract and acts directly on pathogenic bacteria,  mainly used for livestock and poultry intestinal infections. Neomycin Sulfate Supplier-Henrikang is a China  Pharmaceutical intermediate factory specializing in the production of raw materials for veterinary drugs. We have rich  export experience. Bacteria have partial or complete cross-resistance to streptomycin, neomycin, kanamycin and gentamicin.

Pharmacokinetics of Neomycin Sulfate Powder:

Neomycin sulfate is a broad-spectrum Antibacterial agent. The mechanism of action is to inhibit the synthesis of bacteriophage proteins. It has a strong killing effect on most G- bacteria (such as Escherichia coli, Salmonella, Pasteurella, Aspergillus, etc.) and a few G+ bacteria (such as Staphylococcus aureus, Pneumococcus, etc.). It has high concentration in the intestinal tract and acts directly on pathogenic bacteria, mainly used for livestock and poultry intestinal infections. Bacteria are slow to develop resistance to neomycin.Neomycin sulfate belongs to the aminoglycoside class of antibiotics.

Neomycin preferentially interacts with the nuclease-substrate complex and this interaction leads to a decrease in cleavage rate, which is achieved by stabilizing the ground state of the complex and destabilizing the transition state of the cleavage step.Neomycin Sulfate Powder is Broad-spectrum antibiotic that acts well against B. aureus, B. diphtheriae and B. anthracis, blocking voltage-sensitive Ca2+ channels without affecting the neuronal Na+/Ca2+ reverse transporter protein (antiporter). Binds to ribosomal 30S and 50S subunits causing protein misencoding; inhibits initiation and prolongation at protein synthesis initiation. Antimicrobial spectrum:Gram-negative and positive bacteria.

Clinical Application of Neomycin Sulfate Powder:

It is used for the prevention and treatment of dysentery, diarrhea and stunting caused by E. coli and Salmonella in pigs, chickens, cattle and other livestock. It can also be used as enteritis treatment for fish and shrimps in aquaculture. Neomycin sulfate is mainly used for the treatment of diarrhea, watery stool and yellow-green stool caused by E. coli, salmonellosis, cholera and white diarrhea in poultry. Pig yellow and white dysentery, swine dysentery, edema disease and other intestinal infections caused by dysentery, hemorrhagic dysentery, etc. Fish: Enteritis disease of fish. Neomycin sulfate is an aminoglycoside antibiotic.

It has good antibacterial effect on Enterobacteriaceae bacteria such as Staphylococcus spp.(methicillin sensitive strain), Corynebacterium spp., Escherichia coli, Klebsiella spp. and Aspergillus spp. and has poor activity on various groups of Streptococcus, Streptococcus pneumoniae and Enterococcus spp. Pseudomonas aeruginosa, anaerobic bacteria, etc. are resistant to this product. The bacteria have partial or complete cross-resistance to streptomycin, neomycin and kanamycin, gentamicin. Neomycin has significant nephrotoxicity and ototoxicity when administered systemically, so it is currently limited to oral or topical application.

Neomycin sulfate is an aminoglycoside antibiotic. It has good antibacterial effect on Staphylococcus spp (methicillin sensitive strain), Corynebacterium spp, Escherichia coli, Klebsiella spp, Aspergillus spp and other Enterobacteriaceae bacteria, but has poor activity on all groups of Streptococcus, Streptococcus pneumoniae, Enterococcus spp. Pseudomonas aeruginosa, anaerobic bacteria, etc. are resistant to this product. The bacteria have partial or complete cross-resistance to streptomycin, neomycin and kanamycin, gentamicin. Property: It is white or off-white powder; odorless; very easy to induce moisture; aqueous solution shows right light. It is very soluble in water, but almost insoluble in ethanol, ether, acetone or chloroform.