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Firocoxib Raw Materials powder Firocoxib
Product Overview:
Fecoxib is an important non-steroidal anti-inflammatory drug for animal use. Its main effect is to selectively inhibit the synthesis of COX-2 mediated prostaglandin, so as to block the conversion of arachidonic acid into prostaglandin, and then produce antipyretic, analgesic and anti-inflammatory effects. Compared with other non-steroidal anti-inflammatory veterinary drugs, felocoxib can efficiently and selectively inhibit COX-2, and can be quickly absorbed by the body, and has a significant effect on relieving osteoarthritis pain.
Firocoxib Raw Materials powder Firocoxib Attributes
CAS:189954-96-9
MF:C17H20O5S
MW:336.4
EINECS:200-001-2
Specification: 99% min Firocoxib powder
Sample:Firocoxib powder
Packaging:1kg/bag, 25kg/drum
From:Henrikang
Appearance:white
Shelf Life: 2 Years
Test Method: HPLC
Firocoxib Raw Materials powder Firocoxib Details
Firocoxib powder Usage and Synthesis.
Firocoxib is a non-steroidal anti-inflammatory drug, is mainly used to relieve pain and inflammation caused by osteoarthritis and clinical surgery in dogs. its main component, , selectively inhibits the synthesis of prostaglandins mediated by cyclooxygenase-2 (COX-2) , has antipyretic, analgesic and anti-inflammatory effects. In whole blood tests in vitro, felocoxib was about 380 times more selective to COX-2 than to COX-1. moreover, Luo Kao yesterday the bioavailability of 36.9 ( + 20.4) % , Tmax ( Tmax) was 1.25 (0.85) + hours, peak concentration ( Cmax) 0.52 ( + / - 0.22) mu g/ml, half-life (t1/2) is 7.59 (±1.53) hours. Firocoxib is metabolized primarily in the liver by dealkylation and glucosylation, and eliminated by bile and gastrointestinal tract.
Uses of Firocoxib powder.
Phylocoxib is a non-steroidal anti-inflammatory drug . It exerts antipyretic, analgesic and anti-inflammatory effects by selectively inhibiting cyclooxygenase-2 (COX-2) mediated prostaglandin synthesis. In veterinary medicine, filocoxib chewable tablets are specifically designed to relieve osteoarthritis in dogs and pain and inflammation caused by clinical procedures.
The drug acts selectively on COX-2, about 380 times more selectively than on COX-1, , which is significant in reducing gastrointestinal side effects. In addition, the use of felocoxib is subject to some restrictions, for example, its perioperative use is prohibited, until the animal recovers from anesthesia and has normal blood pressure; concomitant use with other non-steroidal anti-inflammatory drugs and glucocorticoids is prohibited or within 24 hours, and concomitant use with potentially nephrotoxic drugs is prohibited.
Preparation method of Firocoxib powder.
Compound A is used as starting material to react with acetoxy-acetyl chloride to form compound B. Compound B was added to DBU and reacted at 80℃ for at least 18h to obtain compound C. Compound C was then reacted with cyclopropyl bromomethane in the solvent DMF under the condition of NaH as base to produce feloxicillin
Product Method of Bulk Firocoxib powder.
