Veterinary Medicine Amphotericin B Powder Antifungal CAS 1397-89-3 Raw Materials

CAS: 1397-89-3

MF: C47H73NO17

MW: 924.08

EINECS: 215-742-2

Specification​: 99% min Amphotericin B 

Sample: Amphotericin B Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance: Yellow Powder

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Portal:https://henrikang.en.made-in-china.com/

Amphotericin B Powder Usage and Synthesis.

Amphotericin B Powder is the drug of choice for deep fungal infections with a broad antifungal spectrum.

Veterinary Medicine Amphotericin B has inhibitory effect on Cryptococcus, Coccidioides, Candida albicans, and Bacillus, etc., and is bactericidal at Amphotericin B has inhibitory effect on Cryptococcus, Coccidioides, Candida albicans, and Bacillus, etc, and is bactericidal at high concentration, which is an effective drug for the treatment of deep fungal infections. 

Amphotericin B Raw MaterialsLight yellow to orange-yellow needle-like crystals or powder.Amphotericin B Powder is a polyene antifungal drug.

Amphotericin B Powder is a polyene antifungal drug. Appearance is yellow or orange-yellow powder, odorless or almost odorless, tasteless, with moisture-attracting property, easy to be destroyed and invalidated under sunlight.

Gradually decompose above 170℃, unstable at 37℃;. Soluble in dimethyl sulfoxide, slightly soluble in dimethylformamide, very slightly soluble in methanol, insoluble in water, anhydrous ethanol, chloroform or ether. It can form salt in neutral or acidic medium, its water solubility increases but the antibacterial activity decreases, its deoxycholate complex is light yellow powder, can form a gelatinous solution in water, can be used for injection.

Uses and functions of Amphotericin B Powder.

Amphotericin B combines with lipohydrols (plasma membrane sterols on fungi) in the cell membrane of fungi and causes a change in the permeability of the cell membrane, resulting in the leakage of intracellular components, potassium ions and other components such as amino acids and proteins to the outside of the membrane, which destroys the normal metabolism of the fungus and inhibits its growth, and the cell lysis results in the cell death of the fungus cells.

Since the cell membrane of bacteria does not contain ergosterol, this drug has no inhibitory or killing effect on bacteria. On the other hand, cholesterol is the main component in the cell membranes of human and animals, and cholesterol has a certain affinity with Amphotericin B, so it has a certain toxicity to the human body.

Amphotericin B is the drug of choice for deep fungal infections with a broad antifungal spectrum. It has inhibitory effect on Cryptococcus, Coccidioides, Candida albicans and Bacillus, etc. It is bactericidal at high concentration, and is an effective drug for the treatment of deep fungal infections. The main clinical indications are as follows:

• ①Treatment of cryptococcosis, North American budding mycosis, disseminated candidiasis, coccidioidomycosis, histoplasmosis.
• ② Treatment of trichothecosis caused by Rhizoctonia, Ploughshares, Endocytosis and Frog Faecal Mycobacteria.
• ③Treatment of sporotrichosis caused by Schenkosporium spp.
• ④ Treatment of trichothecosis caused by Aspergillus fumigatus.
• ⑤ Topical preparations are indicated for coloring fungal diseases, post-burn skin fungal infections, respiratory tract Candida, Aspergillus or Cryptococcus infections, and fungal corneal ulcers.
• 

Pharmacological Effects of Amphotericin B Powder.

Pale yellow to orange-yellow needle-like crystals or powder. Insoluble in water, ethanol, soluble in acidic DMF, DMSO, slightly soluble in DMF, acidic or alkaline aqueous lower alcohol. Odorless, almost tasteless.

Easily destroyed by light, heat and acid. UsesThe product has a powerful inhibitory effect or killing effect on a variety of fungal infections, such as Cryptococcus neoformans, Candida albicans, Histoplasma capsulatum, Dermatophytes, Schenk's sporotrichum, Trichoderma reesei and Coccidioides vulgaris. The product is mainly used for deep fungal diseases of choice.

Uses Amphotericin B is a polyene antifungal drug. It binds with sterols on the cell membrane of fungi, impairing the permeability of the membrane, leading to the leakage of potassium ions, nucleotides and amino acids in the fungal cells, destroying the normal metabolism and inhibiting the fungal effect.

Production method of Amphotericin B Powder.

The strain of Streptomyces nodosus is used as the bacterial strain, and the deep fermentation is carried out in the liquid medium containing carbohydrates and organic nitrogen sources with aeration, and the amphotericin is extracted from the fermentation broth when it reaches the equivalent potency unit.

Amphotericin contains two components, A and B. The A component is of low toxicity and weak antifungal effect, and is not used in the clinic, while the B component has a strong effect, and is called Amphotericin B.