Norfloxacin Lactate Powder CAS 70458-96-7 Raw Materials

CAS: 70458-96-7

MF: C16H18FN3O3

MW: 319.33

EINECS: 274-614-4

Specification​: 99% min Norfloxacin Lactate

Sample: Norfloxacin Lactate Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance: White Powder

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Portal:https://henrikang.en.made-in-china.com/

　Norfloxacin Lactate Powder Usage and Synthesis.

　　Norfloxacin Lactate, also known as norfloxacin, is commonly used in the treatment of intestinal infections. Especially in summer and autumn, because bacteria multiply fast, food is easy to go bad, many people eat unclean, and cause bacterial infectious diarrhea.

　　Norfloxacin Lactate is often available at home or during travel.

　　The contents of this product are white to light yellow particles or powder.

　　Norfloxacin Raw Materials have broad-spectrum and efficient antibacterial effects, wide therapeutic range, good oral absorption, and low toxicity. Clinically, Norfloxacin Lactate is mainly used in the treatment of urinary tract infection, biliary tract infection, and intestinal infection, and the effect is significant.

Uses and functions of Norfloxacin Lactate Powder.

　　It is clinically used for infectious diseases caused by sensitive bacteria in urinary tract, intestinal tract, ENT, gynecology, surgery and dermatology, etc. The main indications are as follows:

　　1, Genitourinary infections: simple and complicated urinary tract infections, bacterial prostatitis, gonococcal urinary tract infections and reproductive tract infections.

　　2, Gastrointestinal tract infections.

　　3, Typhoid and other Salmonella infections. Haloperidol is a concentration-dependent drug, that is, the concentration of the drug in the body is proportional to the efficacy, the higher the concentration the better the efficacy.

　　As food will slow down the absorption of haloperidol in the body, taking the drug on an empty stomach before meals has a 2-3 times higher blood concentration than taking the drug after meals, so taking it after meals will make the efficacy of the drug greatly reduced, and may also lead to resistance to haloperidol or even similar antimicrobial drugs in sensitive bacteria.

　　It is characterized by wide antibacterial spectrum and strong antibacterial power. It has a powerful antibacterial effect on Escherichia coli, Dryobacterium pneumoniae, Pneumocystis aeruginosa, inguinal bacillus, Aspergillus, Salmonella spp., Shigella spp., Citrobacter spp. and Serratia spp.

　　and other bacteria of the family of Remote Phytobacteriaceae. Linqing is used for sensitive bacteria caused by the urinary system, intestinal tract, hu suction system, surgery, gynecology, gynecology and dermatology and other infectious diseases. It is also used in the treatment of gonorrhea.

Pharmacological Effects of Norfloxacin Lactate Powder.

　　Norfloxacin, together with ofloxacin, levofloxacin and ciprofloxacin, belongs to the third generation of fluoroquinolone antimicrobials, with broad-spectrum antibacterial effects, especially against aerobic gram-negative bacilli, with good in vitro antibacterial activity against the following bacteria.

　　It has good antimicrobial effect on the following bacteria in vitro: most of the bacteria of Enterobacteriaceae, including Enterobacteriaceae, Enterobacteriaceae, Enterobacter aerogenes and other Enterobacteriaceae, Escherichia coli, Klebsiella, Aspergillus, Salmonella, Shigella, Vibrio and Yersinia. Norfloxacin also has antibacterial activity against multi-drug resistant bacteria in vitro.

　　It also has good antibacterial activity against penicillin-resistant Neisseria gonorrhoeae, Haemophilus influenzae and Catamonas. Norfloxacin is a bacteriostatic agent, which inhibits DNA synthesis and replication by acting on the A subunit of bacterial DNA helicase, leading to bacterial death.

Production method of Norfloxacin Lactate Powder.

　　3,4-Dichloronitrobenzene can be obtained by nitration of o-dichlorobenzene or chlorination of p-nitrochlorobenzene. Then in dimethyl sulfoxide, and potassium fluoride reflux, fluoridation to 3-chloro-4-fluoro nitrobenzene.

　　In the presence of aqueous hydrochloric or acetic acid, 3-chloro-4-fluoroaniline was reduced with iron powder. This is followed by refluxing with triethyl orthoformate and diethyl malonate (to yield diethyl ethoxymethylene malonate) in the presence of ammonium nitrate to give the condensation product.

　　Heated cyclization in liquid paraffin or diphenyl ether produces ethyl 7-chloro-6-fluoro-4-hydroxyquinoline-3-carboxylate. Undergoes ethylation and then hydrolysis to give the ethylated product.

　　Finally, it is condensed with piperazine to obtain norfloxacin. The process is relatively mature, the yield is high, generally can reach 40% to 65%, but when the piperazine group is introduced in the 7 position, the by-product of the 6 fluorine atom being replaced can account for 25%, which is difficult to separate and affects the yield. The total yield of p-nitrochlorobenzene is more than 8%.