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Veterinary Medicine Antipyrine Powder CAS 60-80-0 Raw Materials
Product Overview:
Antipyrine Powder is an antipyretic and analgesic, this kind of non-steroidal anti-inflammatory drug has strong antipyretic and analgesic, Veterinary Medicine Antipyrine anti-inflammatory and anti-rheumatic effects. However, due to serious adverse reactions, clinical application has been increasingly reduced, and some of the old varieties have gradually tended to be eliminated.Antipyrine Raw Materials is an analytical reagent. It is used for the analysis of nitric acid, nitrous acid and iodine, for the determination of elements forming complex cations, and for the gravimetric determination of titanium.
Veterinary Medicine Antipyrine Powder CAS 60-80-0 Raw Materials Attributes
CAS: 60-80-0
MF: C11H12N2O
MW: 188.23
EINECS:200-486-6
Specification: 99% min Antipyrine
Sample: Antipyrine Powder
Packaging:1kg/bag, 25kg/drum
Brand: Henrikang
Appearance: White Powder
Storage: Cool Dry Place
Shelf Life: 2 Years
Test Method: HPLC
Veterinary Medicine Antipyrine Powder CAS 60-80-0 Raw Materials Details
Antipyrine Powder Usage and Synthesis.
Antipyrine Powder is an antipyretic and analgesic, this kind of non-steroidal anti-inflammatory drug has strong antipyretic and analgesic, Veterinary Medicine Antipyrine anti-inflammatory and anti-rheumatic effects. However, due to serious adverse reactions, clinical application has been increasingly reduced, and some of the old varieties have gradually tended to be eliminated.
Antipyrine Raw Materials is an analytical reagent. It is used for the analysis of nitric acid, nitrous acid and iodine, for the determination of elements forming complex cations, and for the gravimetric determination of titanium.
Uses and functions of Antipyrine Powder.
Used as an antipyretic and analgesic Used as an analytical reagent for nitric acid, nitrous acid and iodine Used as an analytical reagent for nitric acid, nitrous acid and iodine. Determination of elements that can form complex cations (e.g. bismuth, tin, antimony and mercury). Determination of titanium by gravimetric analysis.
Pharmacological Effects of Antipyrine Powder.
Production method of Antipyrine Powder.
Obtained from 1-phenyl-3-methylpyrazolone-5 by methylation and hydrolysis. In the dry methylation tank, add pyrazolone, then add dimethyl sulfate, raise the temperature to 160 ℃, the reaction 6h, heating water boiling 2h. this methylation reactant into the hydrolysis tank containing sodium hydroxide solution, stirring hydrolysis at 100-110 ℃ for 3h. static layering, take the antipyrine oil layer in the crystallization tank, add distilled water dilution, stirring, cooling down to 10 ℃ or less, precipitate crystals, and precipitate crystals, and then add the antipyrine oil layer. Shake filtration, washing, shake dry to get the crude product of antipyrine.
The crude product is recrystallised with distilled water and decoloured with activated carbon to obtain the finished product. Methylation operation can also use chloromethane or bromomethane as raw materials, such methylation reagent as a methanol solution, a slight excess of 1-naphthyl-3-methyl pyridone stirring reaction.
The methanol is then evaporated, the reaction product is dissolved in water, made slightly basic with sodium hydroxide, the antipyrine is extracted with benzene, recrystallised from benzene, and finally refined and recrystallised in water with activated carbon.
Alternatively, it was prepared by refluxing with equimolar N,N-phenylmethylhydrazine and ethyl acetoacetate heated on an oil bath at 130-160 °C. Antipyrine was extracted from the thick oily liquid with boiling water and then crystals were obtained by evaporation to remove the water.