Trimetlylamine Oxide Raw Materials Powder CAS 1184-78-7

CAS:1184-78-7

MF:C3H9NO

MW:75.11

EINECS:214-675-6

Specification: 99% min Trimetlylamine Oxide Powder

Sample:Trimetlylamine Oxide

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance:Yellow

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Trimetlylamine Oxide Powder Usage and Synthesis.

Trimethylamine N-oxide (TMAO) is an intestinal-derived flora metabolite and a potential risk factor for cardiovascular and other chronic diseases.

The process of TMAO production involves the conversion of choline, L-carnitine, and betaine to trimethylamine by intestinal flora. Trimethylamine is absorbed in the intestinal tract, converted to TMAO by trimethylamine oxidase, and then metabolized by the kidneys and excreted in the urine.

Studies have shown that TMAO promotes the development of atherosclerosis and is associated with the risk of cardiovascular events, while TMAO is also associated with chronic diseases such as kidney disease, obesity, type 2 diabetes and cancer.

Currently, changes in the levels of TMAO and related metabolites can be detected by LC-MS, and Microbio can detect the levels of TMAO in samples such as feces and blood.

Uses and functions of Trimetlylamine Oxide.

Trimethylamine N-oxide (TMAO) is an enterogenic flora metabolite that is a potential risk factor for cardiovascular and other chronic diseases. TMAO has been found to promote the development of atherosclerosis and is associated with the risk of cardiovascular events.

TMAO is becoming a risk factor for a growing number of chronic diseases, including kidney disease, obesity, type 2 diabetes, and cancer. Changes in the levels of TMAO and related metabolites can be detected by LC-MS. Microbio can detect TMAO in feces, blood and other samples.

Trimethylamine oxide (CH3)3NO is widely distributed in the body of marine animals and has a role in maintaining the balance of leaching concentrations between cell-somatic fluids and between somatic fluids and the outside world.

It is found in the urine of marine bony fishes in amounts of only a few percent of the total nitrogen excreted. It is synthesized in crustaceans but no evidence of synthesis has been found in fish and is generally believed to be of dietary origin.

Usage method of Trimetlylamine Oxide.

Product method of Bulk Trimetlylamine Oxide Powder.

100 ml of aqueous trimethylamine solution was mixed with 600 ml of hydrogen peroxide solution and left at room temperature for 24 h. If there was still an odor of the amine, another 100-200 ml of hydrogen peroxide solution was added, and when all the amine had been oxidized, it was evaporated to dryness under reduced pressure. The residue was recrystallized with an ethanol-ether mixture. Trimethylamine oxide dihydrate was obtained as long needle-like crystals in 95% yield.

Decompression in an oil bath to 1.33 ~ 1.6kpa and heated to 120 ° C, slowly warmed to 150 ° C, when the water is driven off, warmed to 180 ° C ~ 200 ° C, pure anhydrous trimethylamine oxide that sublimation in the colder neck of the bottle. 

It was first heated at atmospheric pressure to evaporate the solvent until the boiling point reached 152 to 153°C. The solvent was then removed from the flask. The solvent was then depressurized with a pump to remove the residual solvent. At the end of the distillation the temperature of the oil bath was slowly raised to 120°C. The remaining anhydrous trimethylamine oxide weighs 30g.