Veterinary Medicine Inosine CAS 58-63-9 Raw Materials Powder

CAS: 58-63-9

MF:  C10H12N4O5

MW:  268.23

EINECS: 200-390-4

Specification​: 99% min Inosine 

Sample: Inosine Powder

Brand: Henrikang

Appearance: White Powder

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Portal:https://henrikang.en.made-in-china.com/

Inosine Powder Usage and Synthesis.

Inosine Powder (English: Inosine), also known as hypoxanthine, hypoxanthine nucleoside, etc., is a white needle-like crystal with no odor and a slightly bitter taste. Inosine CAS 58-63-9 is a nucleoside compound made from hypoxanthine combined with ribose. Inosine Raw Materials oral solution is mainly used for acute and Inosine Raw Materials is used as an adjunct to the treatment of acute and chronic hepatitis. 

Inosine Powder can be used to treat leukopenia and thrombocytopenia due to various causes. It can cause mild diarrhea and should not be combined with It can cause mild diarrhea and should not be combined with lactic acid, chloramphenicol, pentoxifylline and thiopental sodium injection.

Application/Function of Inosine Powder.

• Inosine oral solution is mainly used as an adjunctive treatment for acute and chronic hepatitis. Among them are mild and moderate chronic hepatitis: the early symptoms of typical chronic hepatitis are mild and lack specificity, fluctuating intermittently, or even without any symptoms for years. The most common are easy fatigue and stomach discomfort, which can easily be overlooked and mistaken for stomach problems;
• Involved in energy metabolism and protein synthesis in the body. Can be used to treat leukopenia and thrombocytopenia due to various causes. Can cause mild diarrhea and should not be combined with lactic acid, chloramphenicol, pansentin and thiopental sodium injection.
• Inosine Powder is used in biochemical studies. Medicine is used to promote leukocyte growth.

• Patients with insidious cirrhosis are often seen clinically, who do not feel obvious discomfort and do not undergo routine physical examination before the appearance of cirrhosis, which gradually develops into cirrhosis unknowingly; occasionally patients develop nausea, abdominal distension, jaundice and dark urine, but the severity of chronic hepatitis cannot be judged based on symptoms.
• Inosine has almost no toxicity and side effects, and can directly enter human cells through cell membranes, so that cells in a human hypoenergetic and hypoxic state can continue to metabolize smoothly, and can activate pyruvate oxidase classes to participate in human protein synthesis. It is mainly used for various types of liver diseases, heart diseases, leukopenia, thrombocytopenia, central retinitis and prevention and relief of side effects caused by antimony.
• It is white crystalline powder; odorless; slightly bitter taste. It is slightly soluble in water, insoluble in chloroform and ethanol, and soluble in dilute hydrochloric acid or sodium hydroxide and other alkaline solutions. The saturated aqueous solution of this product contains about 1.5% inosine. mp218℃(decomposition).

Production Method of Inosine Powder

Inosine can be produced by direct fermentation method or by semi-synthesis method. The semi-synthetic method uses disodium inosinate produced by fermentation as raw material, and inosine is obtained by dephosphorylation.

The preparation of disodium inosinate by inosinic acid dephosphorylation method rod-shaped bacillus 269 fermentation, fermentation broth de-bacterization, adsorption, elution, concentration, addition of ethanol, pH 7-7.5 conditions crystallization can be obtained disodium inosinate.

Bacillus rotundus 269 [fermentation] → fermentation broth [decolonization, adsorption, elution, concentration] → concentration [ethanol] → [pH 7-7.5] Disodium inosinate Preparation of crude inosinate in acetate buffer, pH 5.4-5.6, pressure 137-147kPa, dephosphorylation 5h, can be obtained crude inosinate.

Disodium inosinate [acetic acid, pressurized] → inosine refining dissolved in distilled water, pH=6, recrystallized, fine inosine can be obtained.