Metronidazole Powder Used For Veterinary Medicine CAS 443-48-1 Raw Materials

CAS: 443-48-1

MF: C6H9N3O3

MW: 171.15

EINECS: 207-136-1

Specification​: 99% min Metronidazole 

Sample: Metronidazole Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance: White Powder

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Portal:https://henrikang.en.made-in-china.com/

Metronidazole Powder Usage and Synthesis.

Metronidazole Powder is a nitroimidazole antibiotic, also known as methidazole, metronidazole, metronidazole, metronidazole, metronidazole, anaerobic microorganisms have a killing effect, most anaerobic bacteria with a strong antibacterial effect. anaerobic microorganisms have a killing effect, most anaerobic bacteria with a strong antibacterial effect Metronidazole Used For the treatment of Metronidazole Used For the treatment of amoebiasis, trichomoniasis and anaerobic infections.

Metronidazole Raw MaterialsWhite or yellowish crystal or crystalline powder; slight odor, bitter and slightly salty taste.

Metronidazole was initially used to treat vaginal trichomoniasis with remarkable clinical results. Later, it was found that metronidazole could also kill anaerobic bacteria that cause oral infections, and in 1978, it was recognized by the World Health Organization as a potent anti-anaerobic drug, and is widely used in the prevention and treatment of oral anaerobic infections.

It is widely used in hospitals for the prevention and treatment of respiratory, gastrointestinal, abdominal and pelvic infections caused by anaerobic bacteria, skin, soft tissue and bone and joint infections, cardiomyopathies, sepsis and cerebral treatments.

Uses and functions of Metronidazole Powder.

• 1. Metronidazole was first discovered in 1962 to have very effective therapeutic effects on anaerobic infections, and was later listed as the drug of choice for anaerobic infections.
• Clinical application of metronidazole: anti-vaginal trichomonas. Metronidazole is the world's current treatment of trichomoniasis, oral 10mg/kg will be able to treat Trichomonas vaginalis, but not so much as to affect the growth of normal vaginal flora.
• 2. Anti-amoeba infection. Metronidazole can be used to treat both intestinal and extra-intestinal amebiasis, and is the drug of choice for anti-amoebic infections.
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• 3. Prevention of post-surgical infections. Prophylactic use of metronidazole before and after surgery can significantly reduce the rate of wound infection. It is mainly applied to appendectomy, rectal colon surgery, abdominal cavity infection and other anti-infection.
• 4. Treatment of peptic ulcer. Metronidazole can protect mucosa and promote mucosal regeneration. Gastric and duodenal ulcer using metronidazole 1g/day, divided into 3 times, can achieve ideal cure rate and ulcer healing rate.
• 5. Treatment of prolonged cough with abscess caused by bronchopneumonia infection. Metronidazole can rapidly control the infection and improve the conscious symptoms. Hyperlipidemia.
• 6.Metronidazole has obvious hypolipidemic effect, 0.2-0.4g 3 times a day for 4 weeks. Treatment of tetanus. There is literature on the therapeutic effect of metronidazole for tetanus is very good, even higher than penicillin.
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Debridement, injection of antitoxin, and intravenous rehydration are performed in conjunction with the application of metronidazole. It is recognized that 1.6-2.6g per day is taken orally in 3-4 doses; children are given 50mg per kg per day for 1-2 consecutive courses. Oral diseases. Periodontitis, gingivitis, periodontal abscess, upper frontal sinusitis, tonsillitis and so on. Usage is 3 times a day, each time 0.2-0.8g, one week for a course of treatment.

Pharmacological Effects of Metronidazole Powder.

Metronidazole's nitro group, in the anaerobic environment by the anaerobic bacteria into a cytotoxic active product, inhibits the sensitive bacteria's DNA synthesis, so that the bacteria die and show the effect of anti-anaerobic bacteria, most of the anaerobic bacteria with a strong antimicrobial effect, but the aerobic bacteria and parthenogenetic anaerobic bacteria are ineffective.

It is mainly used for the prevention and treatment of infections caused by anaerobic bacteria, such as respiratory tract, digestive tract, abdominal and pelvic pus infections, infections of soft tissues of the skin, bone and bone joints, endocarditis, sepsis and meningitis caused by Mycobacterium fragileis, and it is widely used in the prevention and treatment of anaerobic infections of the oral cavity.

Production method of Metronidazole Powder.

Obtained by addition of 2-methyl-5-nitroimidazole (see 25010) with ethylene oxide. Dissolve 2-methyl-5-nitroimidazole in formic acid, add ethylene oxide one by one at 30-40°C, and add sulfuric acid in the middle of the addition. After addition, the reaction is 1h. Recover formic acid under reduced pressure, add water to dissolve and cool to 10℃, filter.

The filtrate was adjusted to pH=10 with sodium hydroxide solution, left to cool, filtered, and washed with water to near-medium alteration. Recrystallize with water. Activated carbon decolorization, that is, to obtain metronidazole.