Veterinary API Bulk Raw Tylosin Tartrate Powder

CAS:74610-55-2

MF:C49H81NO23

MW:1052.16

EINECS:616-119-1

Specification: 99% min Tylosin Tartrate Powder

Sample:Tylosin Tartrate Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance: colorless to yellow

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Tylosin Tartrate Powder Usage and Synthesis.

Tylenol tartrate is effective against Gram-positive bacteria and some negative bacteria, but the effect is weak, and stronger against Mycoplasma, which is one of the macrolides with stronger effect on Mycoplasma.

Resistance to tylosin-sensitive bacteria and mycoplasma is easy to produce, and can produce cross-resistance with erythromycin and other antibiotics of this class. Internal tylosin is better absorbed by tartrate, while phosphate is poorly absorbed.

Tartrate is easily absorbed from the gastrointestinal tract (mainly the intestine) after internal administration. The peak blood concentration is reached 1h after internal administration to pigs, and the blood concentration of intramuscular injection or subcutaneous injection of equal amount of tylosin is 2-3 times higher than that of internal administration. The excretion rate of pigs is faster than that of poultry.

Clinically, it is mainly used to prevent and control mycoplasma infections in chickens, turkeys and other animals, and has only a preventive effect but no therapeutic effect on mycoplasma in pigs. In addition, Tylenol is also used for pneumonia, mastitis, uteritis and enteritis caused by Staphylococcus aureus, Streptococcus pyogenes, Vibrio coli and spirochete infections, but it has no obvious curative effect on infections of Escherichia coli and Pasteurella.

Tylosin can also be used in poultry to prevent coccidial infections and soak breeding eggs to prevent the spread of Mycoplasma turkeys.

Uses and functions of Tylosin Tartrate.

1、Mycoplasma diseases: It is mainly used for the prevention and control of Mycoplasma pneumonia in pigs (porcine asthma), Mycoplasma fowlis infection (also known as chronic respiratory disease of chickens), contagious pleuropneumonia in sheep (also known as Mycoplasma pneumonia in sheep), Mycoplasma avium and arthritis, Mycoplasma bovis mastitis and arthritis, and so on.

2、Bacterial diseases: It has good curative effect on diseases caused by many kinds of Gram-positive bacteria, and also has good curative effect on diseases caused by some Gram-negative bacteria.

It is mainly used in the prevention and control of various purulent diseases caused by Staphylococcus aureus, mastitis of cattle and sheep caused by streptococcus, septicaemia of swine, arthritis, meningitis of piglets, equine glanders, traumatic infections and cervicitis, swine dengue caused by Bordetella, swine pneumonic disease caused by Pasteurella, bovine haemorrhagic septicaemia, avian cholera and Pasteurellosis of sheep, horses and rabbits, salmonellosis caused by a variety of livestock and poultry. Salmonellosis, pathogenic Escherichia coli caused by a variety of livestock and poultry colibacillosis, bronchial septic bacillus caused by chronic atrophic rhinitis in pigs.

3, spirochete diseases: swine dysentery caused by porcine spirochetes, goose spirochetes caused by avian spirochetal disease.

4、Anti-coccidiosis: it can prevent and control coccidiosis.

Pharmacological Effect of Tylosin Tartrate.

Pharmacodynamics] Tylenol tartrate is a macrolide antibacterial drug, do mycoplasma effect is stronger, effective against gram-positive bacteria and some negative bacteria. Sensitive bacteria are Staphylococcus aureus, Streptococcus pyogenes, Streptococcus pneumoniae, Corynebacterium pyogenes and so on.

Pharmacokinetics] Intramuscular injection can be rapidly absorbed. Tylenol is widely distributed in the body after absorption as erythromycin, and the organ concentration of the drug given by injection is 2-3 times higher than that of internal administration, but it is not easy to penetrate into the cerebrospinal fluid.

The apparent volume of distribution in dogs and cattle is 1.7L/kg and 1.1L/kg respectively.The concentration of tylosin in milk is about 20% of the serum concentration. Tylosin is excreted in urine and bile in its original form. The elimination half-life of the product is 0.9 hours for dogs and 0.95 to 2.3 hours for calves.

Characteristic of  Bulk Tylosin Tartrate Powder.

Tylosin tartrate is the tartrate of Tylosin, Tylosin (Tylosin) is a special antibiotic for livestock and poultry, a weakly alkaline compound extracted from the culture fluid of Streptomyces. Pro-Chemicalbook bed often tylosin made of tartrate and phosphate. It is white or slightly yellow powder. Slightly soluble in water, can be made into a water-soluble salt with acid, the salt aqueous solution is stable in weak alkaline and weak acidic solution.